Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(6), P. 488 - 509
Published: Feb. 14, 2024
Language: Английский
Citations
62
Epigenetics & Chromatin, Journal Year: 2025, Volume and Issue: 18(1)
Published: Jan. 15, 2025
Colorectal cancer (CRC) remains one of the most common causes cancer-related mortality worldwide. Its progression is influenced by complex interactions involving genetic, epigenetic, and environmental factors. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding (lncRNAs), circular (circRNAs), have been identified as key regulators gene expression, affecting diverse biological processes, notably programmed cell death (PCD). This review aims to explore relationship between ncRNAs PCD in CRC, focusing on how influence survival, proliferation, treatment resistance. A comprehensive literature analysis was conducted examine recent findings role modulating various mechanisms, apoptosis, autophagy, necroptosis, pyroptosis, their impact CRC development therapeutic response. were found significantly regulate pathways, impacting tumor growth, metastasis, sensitivity CRC. Their these pathways highlights potential biomarkers for early detection targets innovative interventions. Understanding involvement regulation offers new insights into biology. The targeted modulation ncRNA-PCD presents promising avenues personalized treatment, which may improve patient outcomes enhancing effectiveness reducing
Language: Английский
Citations
3
Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)
Published: July 29, 2024
Abstract Advancements in the CRISPR technology, a game-changer experimental research, have revolutionized various fields of life sciences and more profoundly, cancer research. Cell death pathways are among most deregulated cells considered as critical aspects development. Through decades, our knowledge mechanisms orchestrating programmed cellular has increased substantially, attributed to revolution cutting-edge technologies. The heroic appearance systems expanded available screening platform genome engineering toolbox detect mutations create precise edits. In that context, ability this system for identification targeting cell signaling result development therapy resistance is an auspicious choice transform accelerate individualized therapy. concept personalized stands on molecular characterization individual tumor its microenvironment order provide treatment with highest possible outcome minimum toxicity. This study explored potential technology precision by identifying specific pathways. It showed promise finding key components involved death, making it tool targeted However, also highlighted challenges limitations need be addressed future research fully realize treatment. Graphical abstract Current application through glance. A choosing appropriate biological model vitro (using established lines, animal derived cells, human stem or T cells), vivo models which can harbor tumor), ex (human/animal-derived organoids). B preparation gRNA library. C design screening, desired gRNAs phenotypic response. D CRISPR-Cas identified targets, Cas9 gene editing (Knockout, base editing, prime editing), RNA modulation (modulation splicing, interference), epigenomic edits interference/activation using dead (dCas9) (Bock et al. 2022b)
Language: Английский
Citations
12
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 18, 2024
The gasdermin (GSDM) protein family plays a pivotal role in pyroptosis, process critical to the body’s immune response, particularly combatting bacterial infections, impeding tumor invasion, and contributing pathogenesis of various inflammatory diseases. These proteins are adept at activating inflammasome signaling pathways, recruiting effector cells, creating an microenvironment, initiating pyroptosis. This article serves as introduction GSDM protein-mediated pyroptosis providing overview GSDMs’ involvement immunity. Additionally, we explore potential applications GSDMs both innovative established antitumor strategies.
Language: Английский
Citations
10
Cells, Journal Year: 2024, Volume and Issue: 13(4), P. 346 - 346
Published: Feb. 16, 2024
Cancer immunotherapy is a novel pillar of cancer treatment that harnesses the immune system to fight tumors and generally results in robust antitumor immunity. Although has achieved remarkable clinical success for some patients, many patients do not respond, underscoring need develop new strategies promote Pyroptosis an immunostimulatory type regulated cell death activates innate system. A hallmark pyroptosis release intracellular contents such as cytokines, alarmins, chemokines can stimulate adaptive activation. Recent studies suggest promotes Here, we review mechanisms by which be induced highlight induce cells defense. We discuss how modulates tumor microenvironment immunity also research areas focus on continued development anticancer treatment. Pyroptosis-based therapies offer promising avenue treating immunologically 'cold' tumors.
Language: Английский
Citations
10
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)
Published: May 25, 2024
Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.
Language: Английский
Citations
10
Cells, Journal Year: 2023, Volume and Issue: 12(4), P. 530 - 530
Published: Feb. 7, 2023
The application of immunotherapy for cancer treatment is rapidly becoming more widespread. Immunotherapeutic agents are frequently combined with various types treatments to obtain a durable antitumor clinical response in patients who have developed resistance monotherapy. Chemotherapeutic drugs that induce DNA damage and trigger (DDR) an increase the expression programmed death ligand-1 (PD-L1) can be employed by cells avoid immune surveillance. PD-L1 exposed on turn targeted re-establish immune-reactive tumor microenvironment, which ultimately increases tumor’s susceptibility therapies. Here we review recent advances how DDR regulates point out effect etoposide, irinotecan, platinum compounds anti-tumor response.
Language: Английский
Citations
24
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: March 20, 2024
Macrophages are highly plastic cells ubiquitous in various tissues, where they perform diverse functions. They participate the response to pathogen invasion and inflammation resolution following immune response, as well maintenance of homeostasis proper tissue generally considered long-lived with relatively strong resistance numerous cytotoxic factors. On other hand, their death seems be one principal mechanisms by which macrophages physiological functions or can contribute development certain diseases. In this review, we scrutinize three distinct pro-inflammatory programmed cell pathways - pyroptosis, necroptosis, ferroptosis occurring under specific circumstances, explain how these appear undergo dynamic yet not always final changes before ultimately dying. We achieve that examining interconnectivity types, seem create a coordinated flexible system responding microenvironment. Finally, discuss complexity consequences pyroptotic, necroptotic, ferroptotic pathway induction two pathological conditions atherosclerosis cancer. summarize damage-associated molecular patterns (DAMPs) along microenvironmental factors, macrophage polarization states, associated general outcomes, such comprehensive look at correlations may point out methodologies potential therapeutic approaches.
Language: Английский
Citations
8
Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 197, P. 104340 - 104340
Published: April 1, 2024
Pyroptosis can be triggered through both canonical and non-canonical inflammasome pathways, involving the cleavage of gasdermin (GSDM) protein family members, like GSDMD GSDME. The impact pyroptosis on tumors is nuanced, because its role in regulating cancer progression anti-tumor immunity may vary depending tumor type, stage, location, immune status. However, cannot simply categorized as promoting or inhibiting based solely whether it acute chronic nature. interplay between intricate, with some evidence suggesting that facilitate growth, while induction could stimulate anti-cancer responses. Tumor hypoxia activates inducible factor (HIF) signaling to modulate checkpoint expression. Targeting this hypoxia-pyroptosis-immune escape axis a promising therapeutic strategy. This review highlights complex crosstalk hypoxia, pyroptosis, evasion TME.
Language: Английский
Citations
7
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 1, 2024
New and emerging pathogens, such as SARS-CoV2 have highlighted the requirement for threat agnostic therapies. Some antibiotics or antivirals can demonstrate broad-spectrum activity against pathogens in same family genus but efficacy quickly reduce due to their specific mechanism of action ability disease causing agent evolve. This has led generation antimicrobial resistant strains, making infectious diseases more difficult treat. Alternative approaches therefore need be considered, which include exploring utility Host-Directed Therapies (HDTs). is a growing area with huge potential difficulties arise complexity profiles. For example, HDT given early during infection may not appropriate effective when become chronic patient intensive care. With understanding immune function, new treatment could allow targeting pathways augment diminish host response, dependent upon profile, bespoke therapeutic management plans. review highlights promising approved HDTs that manipulate system throughout spectrum disease, particular viral bacterial demonstrates how advantages will soon outweigh side effects.
Language: Английский
Citations
7