Endoplasmic Reticulum‐Targeting Iridium(III) Nanosonosensitizer Amplifies Immunogenic Cell Death for Boosted Tumor Sono‐Immunotherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(26)

Published: Feb. 27, 2024

Abstract Reactive oxygen species (ROS)‐induced endoplasmic reticulum (ER) stress in sonodynamic therapy (SDT) can elicit immunogenic cell death (ICD)‐initiated antitumor immunity for augmented sono‐immunotherapy. However, unsatisfactory activity and mediocre ER induction ability of sonosensitizers essentially restrict SDT efficacy ICD stimulation. Herein, a versatile ER‐targeting Iridium(III) nanosonosensitizer is developed as superior inducer boosted tumor An ingenious cholic acid (CA)‐functionalized sonosensitizer Ir‐CA well‐designed skillfully crosslinked with human serum albumin (HSA) to form HSA@Ir‐CA. With high stability, favorable tumor‐targeting ability, reduction‐responsiveness, HSA@Ir‐CA preferentially accumulates sites enhanced cellular uptake, followed by rapid disassembly responding intracellular reductive environment. The uncaged selectively accumulate precisely disrupt situ produced type I II ROS upon US irradiation high‐efficiency SDT. Moreover, the maximized eminently amplifies evoke robust systemic immunity, inhibiting growths primary/distant tumor, lung metastasis, recurrence. This combined immune checkpoint inhibitor (αPD‐L1) further achieves reinforced therapeutic outcome against immunologically “cold” tumor. study presents an effective paradigm optimize amplify ICD‐initiated responses

Language: Английский

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Factors Affecting the Synthesis of Bovine Serum Albumin Nanoparticles Using the Desolvation Method

Nanotechnology Science and Applications, Journal Year: 2024, Volume and Issue: Volume 17, P. 21 - 40

Published: Jan. 1, 2024

Abstract: Currently, protein-based nanoparticles are in high demand as drug delivery systems due to their exceptional qualities, including nontoxicity, nonantigenicity, and biodegradability. Other qualities include nutritional value, abundance of renewable resources, excellent binding capacity, greater stability during storage vivo, well ease upgrading manufacture. Examples protein suitable for this purpose ovalbumin (OVA) derived from egg white, human serum albumin (HSA), bovine (BSA). To create nanoparticles, six different processes have been investigated depth frequently used systems. These included desolvation, thermal gelation, emulsification, NAB technology, self-assembly, nanospray drying. Several experimental conditions the synthesis can affect physicochemical characterization. Therefore, study aimed provide an overview various capable affecting characteristics BSA formed using desolvation method. By considering variation optimal conditions, a system with best characterization results could be developed. Keywords: albumin, BSA,

Language: Английский

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Albumin Nanoparticle-Based Drug Delivery Systems

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6945 - 6980

Published: July 1, 2024

Nanoparticle-based systems are extensively investigated for drug delivery. Among others, with superior biocompatibility and enhanced targeting capacity, albumin appears to be a promising carrier Albumin nanoparticles highly favored in many disease therapies, as they have the proper chemical groups modification, cell-binding sites cell adhesion, affinity protein drugs nanocomplex generation. Herein, this review summarizes recent fabrication techniques, modification strategies, application of nanoparticles. We first discuss various nanoparticle methods, from both pros cons. Then, we provide comprehensive introduction section, including organic nanoparticles, metal inorganic nanoparticle-based hybrids. finally bring further perspectives on used critical diseases.

Language: Английский

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Synthesis, functionalization, and nanomedical applications of functional magnetic nanoparticles

Chinese Chemical Letters, Journal Year: 2018, Volume and Issue: 29(11), P. 1601 - 1608

Published: Aug. 18, 2018

Language: Английский

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Serum protein-based nanoparticles for cancer diagnosis and treatment

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 329, P. 997 - 1022

Published: Oct. 19, 2020

Language: Английский

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