Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1872 - 1872
Published: July 3, 2023
With
the
predicted
rise
in
incidence
of
cancer,
there
is
an
ever-growing
need
for
new
cancer
treatment
strategies.
Recently,
magnetic
nanoparticles
have
stood
out
as
promising
nanostructures
imaging
and
drug
delivery
systems
they
possess
unique
properties.
Moreover,
nanomaterials
functionalized
with
other
compounds
can
lead
to
multicomponent
innovative
structures
synergetic
performance.
The
incorporation
chemotherapeutic
drugs
or
RNA
represents
a
alternative
that
increase
efficiency
reduce
side
effects
anticancer
therapy.
This
review
presents
critical
overview
recent
literature
concerning
advancements
field
used
delivery,
focus
on
their
classification,
characteristics,
synthesis
functionalization
methods,
limitations,
examples
incorporating
chemotherapeutics
RNA.
Redox Biology,
Journal Year:
2023,
Volume and Issue:
63, P. 102754 - 102754
Published: May 18, 2023
Oxidative
stress
(OS),
defined
as
redox
imbalance
in
favor
of
oxidant
burden,
is
one
the
most
significant
biological
events
cancer
progression.
Cancer
cells
generally
represent
a
higher
level,
which
suggests
dual
therapeutic
strategy
by
regulating
status
(i.e.,
pro-oxidant
therapy
and/or
antioxidant
therapy).
Indeed,
exhibits
great
anti-cancer
capability,
attributing
to
accumulation
within
cells,
whereas
restore
homeostasis
has
been
claimed
fail
several
clinical
practices.
Targeting
vulnerability
pro-oxidants
capable
generating
excessive
reactive
oxygen
species
(ROS)
surfaced
an
important
strategy.
However,
multiple
adverse
effects
caused
indiscriminate
attacks
uncontrolled
drug-induced
OS
on
normal
tissues
and
drug-tolerant
capacity
some
certain
greatly
limit
their
further
applications.
Herein,
we
review
representative
oxidative
drugs
summarize
side
organs,
emphasizing
that
seeking
balance
between
damage
value
exploiting
next-generation
OS-based
chemotherapeutics.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Oct. 9, 2023
Abstract
Individual
variability
in
drug
response
(IVDR)
can
be
a
major
cause
of
adverse
reactions
(ADRs)
and
prolonged
therapy,
resulting
substantial
health
economic
burden.
Despite
extensive
research
pharmacogenomics
regarding
the
impact
individual
genetic
background
on
pharmacokinetics
(PK)
pharmacodynamics
(PD),
diversity
explains
only
limited
proportion
IVDR.
The
role
gut
microbiota,
also
known
as
second
genome,
its
metabolites
modulating
therapeutic
outcomes
human
diseases
have
been
highlighted
by
recent
studies.
Consequently,
burgeoning
field
pharmacomicrobiomics
aims
to
explore
correlation
between
microbiota
variation
IVDR
or
ADRs.
This
review
presents
an
up-to-date
overview
intricate
interactions
classical
agents
for
systemic
diseases,
including
cancer,
cardiovascular
(CVDs),
endocrine
others.
We
summarise
how
directly
indirectly,
modify
absorption,
distribution,
metabolism,
excretion
(ADME)
drugs.
Conversely,
drugs
modulate
composition
function
leading
changes
microbial
metabolism
immune
response.
discuss
practical
challenges,
strategies,
opportunities
this
field,
emphasizing
critical
need
develop
innovative
approach
multi-omics,
integrate
various
data
types,
genomic
data,
well
translate
lab
into
clinical
practice.
To
sum
up,
represents
promising
avenue
address
improve
patient
outcomes,
further
is
imperative
unlock
full
potential
precision
medicine.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(27)
Published: July 26, 2022
As
major
complications
of
chemoradiotherapy,
myelosuppression
and
hematopoietic-system
damage
severely
affect
immunologic
function
can
delay
or
even
terminate
treatment
for
cancer
patients.
Although
several
specific
cytokines
have
been
used
hematopoiesis
recovery,
their
effect
is
limited,
they
may
increase
the
risk
tumor
recurrence.
In
this
study,
osteogenic
growth
peptide
functionalized
tetrahedral
framework
nucleic-acid
nanostructures
(OGP-tFNAs)
are
prepared;
combine
positive
stimulating
OGP
drug
carrying
tFNAs.
The
potential
OGP-tFNAs
hematopoietic
stimulation
microenvironment
regulation
investigated.
It
shown
that
protect
bone
marrow
stromal
cells
from
5-fluorouracil
(5-FU)-induced
DNA
apoptosis.
pretreatment
activates
extracellularly
regulated
protein
kinase
signal
downregulates
apoptosis-related
proteins.
also
alleviate
chemotherapy-induced
inhibition
hematopoiesis-related
cytokine
expression,
which
crucial
reconstitution.
conclusion,
injuries
myelosuppression,
while
promoting
regeneration.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(10), P. 2317 - 2317
Published: May 16, 2023
Hyaluronic
acid
(HA),
a
main
component
of
the
extracellular
matrix,
is
widely
utilized
to
deliver
anticancer
drugs
due
its
biocompatibility,
biodegradability,
non-toxicity,
non-immunogenicity
and
numerous
modification
sites,
such
as
carboxyl
hydroxyl
groups.
Moreover,
HA
serves
natural
ligand
for
tumor-targeted
drug
delivery
systems,
it
contains
endocytic
receptor,
CD44,
which
overexpressed
in
many
cancer
cells.
Therefore,
HA-based
nanocarriers
have
been
developed
improve
efficiency
distinguish
between
healthy
cancerous
tissues,
resulting
reduced
residual
toxicity
off-target
accumulation.
This
article
comprehensively
reviews
fabrication
based
on
context
prodrugs,
organic
carrier
materials
(micelles,
liposomes,
nanoparticles,
microbubbles
hydrogels)
inorganic
composite
(gold
quantum
dots,
carbon
nanotubes
silicon
dioxide).
Additionally,
progress
achieved
design
optimization
these
their
effects
therapy
are
discussed.
Finally,
review
provides
summary
perspectives,
lessons
learned
so
far
outlook
towards
further
developments
this
field.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(1)
Published: Jan. 11, 2023
Cancer
is
a
complex
disease
associated
with
combination
of
abnormal
physiological
process
and
exhibiting
dysfunctions
in
multiple
systems.
To
provide
effective
treatment
diagnosis
for
cancer,
current
strategies
simultaneously
focus
on
various
tumor
targets.
Based
the
rapid
development
nanotechnology,
nanocarriers
have
been
shown
to
exhibit
excellent
potential
cancer
therapy.
Compared
nanoparticles
single
functions,
multifunctional
are
believed
be
more
aggressive
potent
context
targeting.
However,
not
simply
an
upgraded
version
original
function,
but
involves
sophisticated
system
proper
backbone,
optimized
modification
sites,
simple
preparation
method,
efficient
function
integration.
Despite
this,
many
well-designed
promising
therapeutic
emerged
recently.
Here,
give
detailed
understanding
analyzation
currently
developed
nanoparticles,
their
platform
structures
organic
or
inorganic
backbones
were
systemically
generalized.
We
emphasized
functionalization
strategies,
which
additional
functions
nanoparticle.
also
discussed
application
that
involved
nanoformulations
functional
crosstalk.
This
review
thus
provides
overview
construction
advances
nanoparticles.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 889 - 889
Published: March 9, 2023
Anticancer
drugs
in
monotherapy
are
ineffective
to
treat
various
kinds
of
cancer
due
the
heterogeneous
nature
cancer.
Moreover,
available
anticancer
possessed
hurdles,
such
as
drug
resistance,
insensitivity
cells
drugs,
adverse
effects
and
patient
inconveniences.
Hence,
plant-based
phytochemicals
could
be
a
better
substitute
for
conventional
chemotherapy
treatment
properties:
lesser
effects,
action
via
multiple
pathways,
economical,
etc.
Various
preclinical
studies
have
demonstrated
that
combination
with
is
more
efficacious
than
individually
because
plant-derived
compounds
lower
efficacy
drugs.
suffer
from
poor
aqueous
solubility
reduced
bioavailability,
which
must
resolved
Therefore,
nanotechnology-based
novel
carriers
employed
codelivery
These
include
nanoemulsion,
nanosuspension,
nanostructured
lipid
carriers,
solid
nanoparticles,
polymeric
micelles,
dendrimers,
metallic
carbon
nanotubes
provide
benefits
improved
solubility,
higher
efficacy,
dose,
dosing
frequency,
bioavailability
compliance.
This
review
summarizes
cancer,
therapy
deliver
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(17), P. 10979 - 11024
Published: April 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
