Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 28, 2025
The
incidence
and
mortality
rates
of
liver
cancer
in
China
remain
elevated.
Although
early-stage
is
amenable
to
surgical
resection,
a
significant
proportion
patients
are
diagnosed
at
advanced
stages.
Currently,
addition
resection
for
hepatocellular
carcinoma,
the
primary
treatment
modalities
predominantly
include
chemotherapy.
widespread
use
chemotherapy,
which
non-selectively
targets
both
malignant
healthy
cells,
often
results
substantial
immunosuppression.
Simultaneously,
accumulation
chemotherapeutic
agents
can
readily
induce
drug
resistance
upon
reaching
physiological
threshold,
thereby
diminishing
efficacy
these
treatments.
Besides
there
exist
targeted
therapy,
immunotherapy
other
therapeutic
approaches.
Nevertheless,
development
remains
an
inevitable
challenge.
To
address
challenges,
we
turn
nanomedicine,
emerging
widely
utilized
discipline
that
significantly
influences
medical
imaging,
antimicrobial
strategies,
delivery
systems,
related
areas.
Stable
safe
nanomaterials
serve
as
effective
carriers
delivering
anticancer
drugs.
They
enhance
precision
targeting,
improve
bioavailability,
minimize
damage
cells.
This
review
focuses
on
common
nanomaterial
used
carcinoma
(HCC)
over
past
five
years.
following
summary
three
drugs:
Sorafenib,
Gefitinib,
lenvatinib.
Each
employs
distinct
result
varying
levels
release
rates,
efficacy.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 7, 2025
Abstract
Metal‐protein
hybrid
materials
represent
a
novel
class
of
functional
that
exhibit
exceptional
physicochemical
properties
and
tunable
structures,
rendering
them
remarkable
applications
in
diverse
fields,
including
engineering,
biocatalysis,
biosensing,
biomedicine.
The
design
development
multifunctional
biocompatible
metal‐protein
have
been
the
subject
extensive
research
key
aspiration
for
practical
clinical
settings.
This
review
provides
comprehensive
analysis
strategies,
intrinsic
properties,
biomedical
these
materials,
with
specific
emphasis
on
their
potential
cancer
therapy,
drug
vaccine
delivery,
antibacterial
treatments,
tissue
regeneration.
Through
rational
design,
stable
can
be
synthesized
using
straightforward
methods,
enabling
therapeutic,
immunomodulatory,
other
desired
functionalities.
Finally,
outlines
existing
limitations
challenges
associated
evaluates
translation,
providing
insights
into
implementation
within
applications.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 20, 2025
The
advent
of
nanozymes
has
revolutionized
approaches
to
cancer
diagnosis
and
therapy,
introducing
innovative
strategies
that
address
the
limitations
conventional
treatments.
Nanozyme
nanostructures
with
enzyme-mimicking
catalytic
abilities
exhibit
exceptional
stability,
biocompatibility,
customizable
functions,
positioning
them
as
promising
tools
for
theranostics.
By
emulating
natural
enzyme
reactions,
can
selectively
target
eradicate
cells,
minimizing
harm
adjacent
healthy
tissues.
Nanozymes
also
be
functionalized
specific
targeting
ligands,
allowing
precise
delivery
regulated
release
therapeutic
agents,
improving
treatment
effectiveness
reducing
adverse
effects.
However,
issues
such
selectivity,
regulatory
compliance
remain
critical
challenges
clinical
application
nanozymes.
This
review
provides
an
overview
nanozymes,
highlighting
their
unique
properties,
various
classifications,
activities,
diverse
applications
in
strategic
oncological
deployment
could
profoundly
impact
future
advancements
personalized
medicine,
recent
progress
prospective
directions
enzyme-mimetic
treatment.
summarizes
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(6), P. 6689 - 6708
Published: Feb. 1, 2024
Tumor
development
and
metastasis
are
closely
related
to
the
complexity
of
metabolism
network.
Recently,
reprogramming
strategies
have
attracted
much
attention
in
tumor
therapy.
Although
there
is
preliminary
success
therapy
agents,
their
therapeutic
effects
been
restricted
by
effective
reaching
sites
drugs.
Nanodelivery
systems
with
unique
physical
properties
elaborate
designs
can
specifically
deliver
tumors.
In
this
review,
we
first
summarize
research
progress
nanodelivery
based
on
enhance
therapies
depleting
glucose,
inhibiting
glycolysis,
lactic
acid,
lipid
metabolism,
glutamine
glutathione,
disrupting
metal
metabolisms
combined
other
therapies,
including
chemotherapy,
radiotherapy,
photodynamic
therapy,
etc.
We
further
discuss
detail
advantages
for
As
well
as
opportunities
challenges
integrating
into
analyze
outlook
these
emerging
areas.
This
review
expected
improve
our
understanding
modulating
enhanced
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(7), P. 648 - 648
Published: April 8, 2024
Nanodynamic
therapy
(NDT)
exerts
its
anti-tumor
effect
by
activating
nanosensitizers
to
generate
large
amounts
of
reactive
oxygen
species
(ROS)
in
tumor
cells.
NDT
enhances
tumor-specific
targeting
and
selectivity
leveraging
the
microenvironment
(TME)
mechanisms
that
boost
immune
responses.
It
also
minimizes
damage
surrounding
healthy
tissues
cytotoxicity
cells,
showing
promise
cancer
treatment,
with
significant
potential.
This
review
covers
research
progress
five
major
nanodynamic
therapies:
photodynamic
(PDT),
electrodynamic
(EDT),
sonodynamic
(SDT),
radiodynamic
(RDT),
chemodynamic
(CDT),
emphasizing
role
advanced
nanotechnology
development
for
purposes.
The
mechanisms,
effects,
challenges
faced
these
NDTs
are
discussed,
along
their
respective
solutions
enhancing
efficacy,
such
as
pH
response,
delivery,
combined
immunotherapy.
Finally,
this
briefly
addresses
clinical
translation
NDT.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 19, 2024
Chemodynamic
therapy
(CDT)
can
induce
cancer
cell
death
through
hydroxyl
radicals
(·OH)
generated
from
Fenton
or
Fenton-like
reactions.
Compared
with
traditional
therapies,
CDT
effectively
overcomes
inevitable
drug
resistance
and
exhibits
low
side
effects.
However,
clinical
application
still
faces
challenges,
primarily
due
to
insufficient
·OH
generation
the
short-lifetime
of
in
vivo.
To
address
these
we
developed
a
peroxynitrite
(ONOO
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(11)
Published: Dec. 20, 2023
Photodynamic
therapy
(PDT)
with
aggregation-induced
emission
(AIE)
photosensitizers
(PSs)
is
a
promising
therapeutic
strategy
to
achieve
better
anticancer
results.
However,
eradicating
solid
tumors
completely
by
PDT
alone
can
be
difficult
owing
the
inherent
drawbacks
of
this
treatment,
and
combination
other
modalities
provides
opportunities
cooperative
enhancement
interactions
among
various
treatments.
Herein,
work
presents
construction
biocompatible
nanocomposite,
namely
CaO
