Biosensors,
Journal Year:
2023,
Volume and Issue:
13(11), P. 968 - 968
Published: Nov. 6, 2023
A
powerful
and
accurate
method
for
identifying
isolating
cells
would
be
of
great
importance
due
to
its
sensitivity,
gentleness
effectiveness.
Here,
we
designed
a
receptor-based
DNA
logic
device
that
allows
Boolean
analysis
multiple
cells.
For
ease
expression,
the
molecules
on
cell
surface
can
bind
aptamer
are
referred
as
"receptors".
This
sends
signals
based
sgc8c
sgc4f
receptor
expression
by
performing
NOT,
NOR,
AND
OR
operations,
amplifies
evaluates
using
HCR.
Meanwhile,
release
ICG
from
endopore
HMSNs
is
controlled
affecting
structural
changes
in
device.
approach
accurately
identify
treat
demand
presence
or
absence
cell-specific
receptors,
facilitating
development
personalized
medicine.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Abstract
Mechanical
force
attracts
booming
attention
with
the
potential
to
tune
tumor
cell
behavior,
especially
in
migration.
However,
current
approach
for
introducing
mechanical
input
is
difficult
apply
vivo.
How
affects
behavior
situ
also
remains
unclear.
In
this
work,
an
intelligent
miniaturized
platform
constructed
magnetic
ZnFe
2
O
4
(ZFO)
micromotors.
The
wireless
ZFO
can
self‐assemble
and
rotate
generate
torque
of
biologically
relevant
piconewton‐scale
at
target
site.
It
observed
unexpectedly
that
enhanced
rotating
from
micromotors
active
fluid
inhibit
migration
highly
invasive
A549
cells.
down‐regulation
Piezo1
channel
suppressed
signaling
ROCK1
mechano‐adaptive
cells
found
be
related
inhibition
effect.
With
effectiveness
confirmed
zebrafish
xenograft
model,
provides
a
valuable
toolkit
mechanobiology
force‐associated
non‐invasive
therapy.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Nov. 11, 2023
Abstract
Elastin-like
polypeptides
(ELPs)
are
thermally
responsive
biopolymers
derived
from
natural
elastin.
These
peptides
have
a
low
critical
solution
temperature
phase
behavior
and
can
be
used
to
prepare
stimuli-responsive
biomaterials.
Through
genetic
engineering,
biomaterials
prepared
ELPs
unique
customizable
properties.
By
adjusting
the
amino
acid
sequence
length
of
ELPs,
nanostructures,
such
as
micelles
nanofibers,
formed.
Correspondingly,
been
for
improving
stability
prolonging
drug-release
time.
Furthermore,
widespread
use
in
tissue
repair
due
their
biocompatibility
biodegradability.
Here,
this
review
summarizes
basic
property
composition
methods
modulating
transition
properties,
discusses
application
drug
delivery
system
clarifies
current
challenges
future
directions
applications.
Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
95(25), P. 9654 - 9662
Published: June 12, 2023
Triple-negative
breast
cancer
is
particularly
difficult
to
treat
because
of
its
high
degree
malignancy
and
poor
prognosis.
A
fluorescence
resonance
energy
transfer
(FRET)
nanoplatform
plays
a
very
important
role
in
disease
diagnosis
treatment
due
unique
detection
performance.
Combining
the
properties
agglomeration-induced
emission
fluorophore
FRET
pair,
nanoprobe
(HMSN/DOX/RVRR/PAMAM/TPE)
induced
by
specific
cleavage
was
designed.
First,
hollow
mesoporous
silica
nanoparticles
(HMSNs)
were
used
as
drug
carriers
load
doxorubicin
(DOX).
HMSN
nanopores
coated
with
RVRR
peptide.
Then,
polyamylamine/phenylethane
(PAMAM/TPE)
combined
outermost
layer.
When
Furin
cut
off
peptide,
DOX
released
adhered
PAMAM/TPE.
Finally,
TPE/DOX
pair
constituted.
The
overexpression
triple-negative
cell
line
(MDA-MB-468
cell)
can
be
quantitatively
detected
signal
generation,
so
monitor
physiology.
In
conclusion,
HMSN/DOX/RVRR/PAMAM/TPE
nanoprobes
designed
provide
new
idea
for
quantitative
delivery,
which
conducive
early
cancer.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(13)
Published: Dec. 21, 2023
Abstract
Almost
all
cancer
treatments
are
significantly
limited
by
the
strong
tumor
microenvironment
(TME)
fortress
formed
abnormal
vasculature,
dense
extracellular
matrix
(ECM),
multidrug
resistance
(MDR)
system,
and
immune
“cold”
environment.
In
huge
efforts
of
dismantling
TME
fortress,
nitric
oxide
(NO)‐based
nanomedicines
increasingly
occupying
a
central
position
have
already
been
identified
as
super
“strong
polygonal
warriors”
to
dismantle
for
efficient
treatment,
benefiting
from
NO's
unique
physicochemical
properties
extremely
fascinating
biological
effects.
However,
there
is
paucity
systematic
review
elaborate
on
progress
fundamental
mechanism
NO‐based
in
oncology
this
aspect.
Herein,
key
characteristics
potential
NO
reprogramming
delineated
highlighted.
The
evolution
donors
advantages
discussed
subsequently.
Moreover,
latest
solid
tumors
comprehensively
reviewed,
including
normalizing
overcoming
ECM
barrier,
reversing
MDR,
reactivating
immunosuppression
TME.
Lastly,
prospects,
limitations,
future
directions
manipulation
provide
new
insights
into
construction
more
applicable
anticancer
nanomedicines.
Journal of materials research/Pratt's guide to venture capital sources,
Journal Year:
2024,
Volume and Issue:
39(12), P. 1741 - 1757
Published: April 30, 2024
Abstract
Fabrications
of
nanomotors
(NMs)
are
at
the
forefront
exploring
true
potential
nanotechnology.
Tubular
(TNMs)
have
been
attracting
huge
interest
recently.
NMs
based
on
2D-hexagonal
mesoporous
silica
(SBA-15)
prepared
through
surfactant-assisted
sol–gel
method.
Copper
and/or
iron
oxide
nanoparticles
impregnated
in
SBA-15
to
form
catalytic
tubular
nanomotors.
Characterization
has
investigated
by
XPS,
XRD,
HR-TEM,
SEM–EDS,
and
BET.
The
electrochemical
measurements
were
used
confirm
motion
By
increasing
loading
metal
nanoparticles,
decreases;
this
could
be
observed
from
current
loss.
anti-cancer
synthesized
against
two
cell
lines
(A549
H460)
human
lung
carcinoma
tested.
Among
all
tested
NMs,
high-metal
oxide-loaded
materials
containing
CuO
only
as
well
Fe
2
O
3
potent
significant
apoptotic
death
for
cancer
treatment.
Graphical
abstract
Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Nov. 14, 2024
Brain
cancer
pose
significant
life-threats
by
destructively
invading
normal
brain
tissues,
causing
dysneuria,
disability
and
death,
its
therapeutics
is
limited
underdosage
toxicity
lying
in
conventional
drug
delivery
that
relied
on
passive
delivery.
The
application
of
nanorobots-based
systems
an
emerging
field
holds
great
potential
for
active
targeting
controllable
treatment.
ability
nanorobots
to
encapsulate,
transport,
supply
therapies
directly
the
lesion
site
through
blood–brain
barriers
makes
it
possible
deliver
drugs
hard-to-reach
areas.
In
order
improve
efficiency
problems
such
as
precision
sustained
release,
are
effectively
realized
converting
other
forms
energy
into
propulsion
motion,
which
considered
high-efficiency
methods
this
article,
we
described
recent
advances
treatment
with
mainly
from
three
aspects:
firstly,
development
history
characteristics
reviewed;
secondly,
research
progress
comprehensively
investigated,
like
driving
mode
mechanism
described;
thirdly,
translation
nanorobotics
diseases
discussed
challenges
opportunities
future
outlined.
Biomacromolecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 11, 2025
Biomolecular
motors
are
dynamic
systems
found
in
organisms
with
high
energy
conversion
efficiency.
FOF1-ATPase
is
a
rotary
biomolecular
motor
known
for
its
near
100%
It
utilizes
the
synthesis
and
hydrolysis
of
ATP
to
induce
conformational
changes
proteins,
thereby
converting
chemical
into
mechanical
motion.
Given
their
efficiency,
autonomous
propulsion
capability,
modifiable
structures,
have
attracted
significant
attention
potential
biomedical
applications.
This
Review
aims
introduce
detailed
structure
FOF1-ATPase,
explore
various
motility
manipulation
strategies,
summarize
applications
biological
detection
cargo
delivery.
Additionally,
innovative
research
methods
proposed
analyze
motion
mechanism
more
comprehensively,
goal
advancing
Finally,
this
concludes
key
insights
future
perspectives.
