Characterization of ZnO-CuO and ZnO-CuO-NiO nanocomposites prepared by co-precipitation and antibacterial properties

Applied Physics A, Journal Year: 2025, Volume and Issue: 131(2)

Published: Jan. 30, 2025

Language: Английский

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Recent trends in Helicobacter pylori management: harnessing the power of AI and other advanced approaches

Beni-Suef University Journal of Basic and Applied Sciences, Journal Year: 2023, Volume and Issue: 12(1)

Published: Sept. 2, 2023

Abstract Background Helicobacter pylori ( H. ) is a bacterial infection that prevalent and affects more than half of the world's population, causing stomach disorders such as gastritis , peptic ulcer disease, gastric cancer. Main body The diagnosis relies on invasive non-invasive techniques emerging artificial intelligence, antibiotic therapy available, but resistance growing concern. development vaccine crucial in preventing -associated diseases, it faces challenges due to bacterium's variability immune escape mechanisms. Despite challenges, ongoing research into pylori's virulence factors mechanisms, well potential targets, provides hope for effective management prevention diseases. Recent mechanisms novel checkpoint inhibitors could also lead biomarkers early cancer detection. Therefore, experts have suggested combination traditional herbal medicine with intelligence potentially eradicate . Short conclusion remains significant global health problem, its properties advanced technologies addition may eradication Graphical abstract

Language: Английский

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Phytonanoparticles as novel drug carriers for enhanced osteogenesis and osseointegration

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 16, 2025

Abstract Phytonanoparticles have emerged as a promising class of biomaterials for enhancing bone regeneration and osseointegration, offering unique advantages in biocompatibility, multifunctionality, sustainability. This comprehensive review explores the synthesis, characterization, applications phytonanoparticles tissue engineering. The green synthesis approach, utilizing plant extracts reducing stabilizing agents, yields nanoparticles with intrinsic bioactive properties that can synergistically promote osteogenesis. We examine mechanisms by which phytonanoparticles, particularly those derived from gold, silver, zinc oxide, influence key molecular pathways osteogenesis, including RUNX2 Osterix signaling. discusses advanced strategies phyto-nanoparticle design, such surface functionalization stimuli-responsive release mechanisms, enhance their efficacy applications. Preclinical studies demonstrating improved osteoblast proliferation, differentiation, mineralization are critically analyzed, along emerging clinical data. Despite results, scalability, standardization, regulatory approval challenges persist. also addresses economic environmental implications production. Looking ahead, we identify research directions, developing personalized therapies, combination approaches stem cells or gene delivery, long-term safety assessments. By harnessing power plant-derived nanomaterials, represent an innovative approach to addressing complex regeneration, potential spanning dental, orthopedic, maxillofacial surgery. Graphical abstract

Language: Английский

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Expanding horizons in theragnostics: from oncology to multidisciplinary applications

La radiologia medica, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

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Enhancing selegiline hydrochloride efficacy: Box Behnken-optimized liposomal delivery via intranasal route for Parkinson’s disease intervention

Journal of Liposome Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: April 9, 2024

The clinical use of selegiline hydrochloride in conventional dosage forms is to reduce the progression Parkinson's disease (PD). However, its limited access brain, short half-life, and first-pass metabolism minimize brain uptake. Nano-based liposomes offer promising tools for brain-targeted delivery therapeutics, especially intranasally administered cationic that target region

Language: Английский

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Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

Small, Journal Year: 2023, Volume and Issue: 19(52)

Published: Aug. 30, 2023

Abstract Antibacterial theranostic nanoplatforms, which integrate diagnostic and therapeutic properties, exhibit gigantic application prospects in precision medicine. However, traditional nanoplatforms usually present an always‐on signal output, leads to poor specificity or selectivity the treatment of bacterial infections. To address this challenge, stimuli‐actuated turn‐on are developed for simultaneous activation signals (e.g., fluorescent, photoacoustic, magnetic signals) initiation antibacterial treatment. Specifically, by combining infection microenvironment‐responsive visual activity, these exert both higher accurate diagnosis rates more effective effects. In review, imaging strategies that commonly used clinic first briefly introduced. Next, recent progress treating infectious diseases is summarized detail. Finally, current bottlenecks future opportunities also outlined discussed.

Language: Английский

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Reassessing the Role of Nanoparticles in Core Fields of Aquaculture: A Comprehensive Review of Applications and Challenges

Aquaculture Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The application of nanoparticles (NPs) in aquaculture has emerged as a promising frontier to enhance productivity, sustainability, and environmental stewardship. This comprehensive review explores the integration NPs across core fields aquaculture, including nutrition, health management, water treatment, breeding performance, sex manipulation, waste management. offer innovative solutions for improving fish growth rates, enhancing feed efficiency, providing targeted drug delivery systems (DDSs) combat diseases. antimicrobial properties effectively target eliminate bacterial, viral, fungal infections. play critical role quality by removing pollutants pathogens, promoting healthier environment. They also aid management breaking down recycling waste, reducing ecological footprint aquaculture. However, concerns about toxicity present significant challenges. Future directions point importance thorough risk assessments, establishment regulatory guidelines, adoption sustainable approaches fully leverage advantages Further research is essential understand long‐term impacts safety aquatic ecosystems. Addressing issues above, industry can adopt more efficient practices, ensuring both food security protection.

Language: Английский

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Innovative green and bio-based approaches for photosensitive nanoparticle synthesis: a review on methodologies, characterization, and applications

Micro and Nano Systems Letters, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 24, 2025

Abstract The increasing demand for sustainable and eco-friendly technologies has recently led to the development of green bio-based synthesis methods a broad range nanoparticles (NPs). This is because these are non-toxic, biocompatible, cost-effective. Photosensitive (PSNPs) have gained popularity due their photo-responsive properties. PSNPs also been found be promising nanomaterials with applications in optoelectronics, photocatalysis, photovoltaics, bioimaging, drug delivery, cancer treatment. However, conventional raise concerns about environmental impact. To address challenges, researchers explored alternative approaches PSNPs. review comprehensively evaluates advantages limitations highlights unique properties various fields. It covers general concepts PSNPs, mechanism action, characterization techniques, challenges that not discussed detail previous studies. Moreover, this uniquely addresses potential solutions scaling up methods, an aspect often overlooked existing literature. By connecting fundamental research industrial-scale applications, offers comprehensive perspective on production emphasizing multiple Graphical

Language: Английский

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Lipid-based nanomedicines for the treatment of bacterial respiratory infections: current state and new perspectives

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(4), P. 325 - 343

Published: Jan. 25, 2024

The global threat posed by antimicrobial resistance demands urgent action and the development of effective drugs. Lower respiratory tract infections remain deadliest communicable disease worldwide, often challenging to treat due presence bacteria that form recalcitrant biofilms. There is consensus novel anti-infectives with reduced compared conventional antibiotics are needed, leading extensive research on innovative antibacterial agents. This review explores recent progress in lipid-based nanomedicines developed counteract bacterial infections, especially those involving biofilm growth; focuses improved drug bioavailability targeting highlights strategies enhance treatment efficacy while emphasizing importance continued this dynamic field.

Language: Английский

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Systematic review of antibacterial potential in calcium oxide and silicon oxide nanoparticles for clinical and environmental infection control

Journal of Applied Biomedicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

A substantial threat to worldwide health, the proliferation of antibiotic-resistant bacteria compels researchers seek innovative antibacterial substances. This systematic review assesses role nanoparticles, particularly Calcium oxide and Silicon in infection control. The article examines mechanisms by which these nanoparticles act against various evaluates their potential as novel agents control strategies. literature search from 2015 2024 encompassing Web Science, PubMed, Wiley, Science Direct, Google Scholar, yielded 70 publications meeting criteria. comprehensive methodology provides a thorough understanding capabilities limitations agents. aims build solid foundation for utilization addressing obstacles presented antibiotic resistance combining data investigations. Additionally, it explore safety environmental implications associated with use clinical settings, providing analysis that may contribute future studies real-world applications field antimicrobial technology.

Language: Английский

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