PubMed,
Journal Year:
2024,
Volume and Issue:
49(8), P. 1316 - 1326
Published: Aug. 28, 2024
Immunotherapy
has
led
to
groundbreaking
advances
in
anti-tumor
treatment,
yet
significant
clinical
challenges
remain
such
as
the
low
proportion
of
beneficiaries
and
lack
effective
platforms
for
predicting
therapeutic
response.
Organoid
technology
provides
a
novel
solution
these
issues.
Organoids
are
three-dimensional
tissue
cultures
derived
from
adult
stem
cells
or
pluripotent
that
closely
replicate
structural
biological
characteristics
native
organs,
demonstrating
particularly
strong
potential
modeling
tumor
microenvironment
(TME).
Tumor
organoids
can
simulate
TME
effectively
by
retaining
endogenous
matrix
components,
including
various
immune
cells,
adding
cancer-associated
fibroblasts,
other
components.
This
platform
immunotherapy
outcomes,
evaluating
adoptive
cell
therapies,
selecting
personalized
treatment
options
patients.
Summarizing
strategies
constructing
understanding
their
advancements
research
application
provide
new
insights
development
immunotherapy.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 21, 2025
Tumor
drug
resistance
presents
a
growing
challenge
in
medical
practice,
particularly
during
anti-cancer
therapies,
where
the
emergence
of
drug-resistant
cancer
cells
significantly
complicates
clinical
treatment.
In
recent
years,
three-dimensional
(3D)
tumor
culture
technology,
which
more
effectively
simulates
vivo
physiological
environment,
has
gained
increasing
attention
research
and
applications.
By
mimicking
cellular
microenvironment,
3D
technology
not
only
recapitulates
cell-cell
interactions
but
also
faithfully
reproduces
biological
effects
therapeutic
agents.
Consequently,
is
emerging
as
crucial
tool
biomedical
research.
We
summarize
benefits
models
organoid
explore
their
application
realm
resistance,
screening,
personalized
therapy,
discuss
potential
prospects
challenges
transformation,
with
aim
providing
insights
for
optimizing
treatment
strategies
advancing
precision
therapy.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5414 - 5414
Published: May 16, 2024
The
evaluation
of
nanostructured
biomaterials
and
medicines
is
associated
with
2D
cultures
that
provide
insight
into
biological
mechanisms
at
the
molecular
level,
while
critical
aspects
tumor
microenvironment
(TME)
are
provided
by
study
animal
xenograft
models.
More
realistic
models
can
histologically
reproduce
human
tumors
tissue
engineering
methods
co-culturing
cells
varied
phenotypes
to
3D
spheroids
recapitulate
dynamic
TME
in
matrices.
novel
approaches
creating
combined
(TTE)
scaffolds
including
hydrogels,
bioprinted
materials,
decellularized
tissues,
fibrous
This
review
focuses
on
use
materials
cancer
therapy
regeneration,
development
for
studying
immune
characteristics.
Tissue
regeneration
an
important
aspect
TTE
used
restoring
normal
function
providing
treatment.
Thus,
this
article
reports
recent
advancements
antitumor
drug
screening,
metastasis,
regeneration.
Also,
identifies
significant
opportunities
using
immunological
processes
involved
application
immunotherapies.
Oncology Reports,
Journal Year:
2024,
Volume and Issue:
52(2)
Published: June 21, 2024
Radiotherapy
exhibits
significant
versatility
and
efficacy
in
cancer
treatment,
thereby
playing
a
crucial
role
the
field
of
oncology.
However,
there
remains
an
urgent
need
for
extensive
research
on
various
aspects
radiotherapy,
including
target
selection,
damage
repair
its
combination
with
immunotherapy.
Particularly,
development
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
unknown, P. 107420 - 107420
Published: Sept. 1, 2024
Endometrial
cancer
(EC)
is
one
of
the
most
common
gynecologic
malignancies,
which
lacking
effective
drugs
for
intractable
conditions
or
patients
unsuitable
surgeries.
Recently,
patient-derived
organoids
(PDOs)
are
found
feasible
research
and
drug
discoveries.
Here,
we
established
a
series
PDOs
from
EC
performed
repurposing
screening
mechanism
analysis
treatment.
We
confirmed
that
regulatory
β
subunit
methionine
adenosyltransferase
(MAT2B)
highly
correlated
with
malignant
progression
in
endometrial
cancer.
Through
on
PDOs,
identify
JX24120,
chlorpromazine
derivative,
as
specific
inhibitor
MAT2B,
directly
binds
to
MAT2B
(K
Immuno,
Journal Year:
2024,
Volume and Issue:
4(4), P. 312 - 324
Published: Sept. 27, 2024
Recent
advances
in
organoid
technology
have
revolutionized
cancer
biology
and
therapeutic
interventions,
offering
personalized
immunotherapy
treatment.
Organoids,
three-dimensional
cell
cultures
derived
from
patient
tumors,
accurately
replicate
the
tumor
microenvironment,
providing
unprecedented
insights
into
tumor-immune
interactions
responses.
In
this
literature-based
study,
we
discuss
various
culture
methods
for
diverse
applications
of
organoids
immunotherapy,
including
drug
screening,
treatment
strategies,
mechanistic
studies.
Additionally,
address
technological
challenges
associated
with
these
propose
potential
future
solutions
to
accelerate
development
novel
immunotherapeutic
approaches.
This
review
highlights
transformative
models
advancing
preclinical
modeling,
evaluation,
paving
way
more
effective
treatments.
