Therapeutic Delivery,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 10
Published: Feb. 24, 2025
A
new
self-nanoemulsifying
drug
delivery
system
(SNEDDS)
was
developed
for
erlotinib
(Ert)
oral
delivery.
pseudo-ternary
phase
diagram
olive
oil,
Tween
80
and
polyethylene
glycol
(PEG)
600
mixtures,
firstly
constructed.
Based
on
the
data
about
Ert
solubility
cytotoxicity
of
these
components,
a
SNEDDS
composed
10%
20%
70%
(V/V)
selected
loading
(Ert-SNEDDS).
formed
31.2-nm
droplets
upon
dilution
in
water,
led
to
increment
oil
83.9
±
0.6
nm.
Ert-SNEDDS
represented
capacity
an
entrapment
efficiency
22.7
0.7
40.7
0.5%,
respectively.
release
from
monitored
both
mixture
phosphate
buffer
saline
0.5%
80,
artificial
gastric
fluid.
orally
administrated
rats,
plasma
level
over
time
measure
pharmacokinetic
parameters.
enhancement
bioavailability
changed
route
Ert.
showed
enhanced
toward
ASPC-1
PANC-1
cells,
half-maximal
inhibitory
concentration
values
were
obtained
compared
with
free
may
be
considered
as
alternative
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Abstract
Natural
remedies
are
gaining
attention
as
promising
approaches
to
alleviating
inflammation,
yet
their
full
potential
is
often
limited
by
challenges
such
poor
bioavailability
and
suboptimal
therapeutic
effects.
To
overcome
these
limitations,
we
have
developed
a
novel
nano-antioxidant
(EK)
based
on
epigallocatechin
gallate
(EGCG)
aimed
at
enhancing
the
oral
systemic
bioavailability,
well
anti-inflammatory
efficacy,
of
curcumin
(Cur)
in
conditions
acute
colon
kidney
inflammation.
EK
synthesized
using
straightforward
Mannich
reaction
between
EGCG
L-lysine
(K),
resulting
formation
oligomers.
These
oligomers
spontaneously
self-assemble
into
nanoparticles
with
spherical
morphology
an
average
diameter
approximately
160
nm.
In
vitro
studies
reveal
that
exhibit
remarkable
radical-scavenging
capabilities
effectively
regulate
redox
processes
within
macrophages,
key
component
body’s
inflammatory
response.
By
efficiently
encapsulating
nanoparticles,
create
Cur@EK,
formulation
demonstrates
synergistic
effect.
Specifically,
Cur@EK
significantly
reduces
levels
pro-inflammatory
cytokines
TNF-α
IL-6
while
increasing
cytokine
IL-10
lipopolysaccharide-stimulated
highlighting
its
potent
properties.
When
administered
either
orally
or
intravenously,
shows
superior
compared
free
exhibits
pronounced
effects
mouse
models
ulcerative
colitis
injury.
findings
suggest
platform
not
only
enhances
but
also
amplifies
impact,
offering
new
avenue
for
treatment
management
inflammation
both
contexts.
Theranostics,
Journal Year:
2024,
Volume and Issue:
15(4), P. 1439 - 1455
Published: Dec. 31, 2024
Rationale:
Next-generation
wound
dressings
with
multiple
biological
functions
hold
promise
for
addressing
the
complications
and
pain
associated
burn
wounds.
Methods:
A
hydrogel
dressing
loaded
a
pain-relieving
drug
was
developed
treating
infected
Polyvinyl
alcohol
chemically
grafted
gallic
acid
(PVA-GA),
sodium
alginate
3-aminobenzeneboronic
(SA-PBA),
Zn2+,
chitosan-coated
borneol
nanoparticles
anti-inflammatory
activities
were
combined
to
afford
nanoparticle-loaded
PVA-GA/Zn2+/SA-PBA
network
crosslinked
via
physicochemical
interactions.
Results:
The
demonstrated
adhesiveness,
self-healing,
shape
adaptability,
injectability,
degradability,
conformity
complicated
surfaces,
other
desirable
functions,
including
pH-responsive
release
behavior
antibacterial,
antioxidant,
anti-inflammatory,
proangiogenic
activities.
In
murine
scald
model,
effectively
prevented
infection
by
Staphylococcus
aureus
downregulated
perception
(measured
using
mouse
grimace
scale
scores
hind
paw
lifting
licking
times),
thereby
accelerating
healing.
Conclusion:
This
study
provides
broad
prospects
development
of
new
systems
that
can
substantially
improve
dynamic
management
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 19, 2025
Abstract
The
rational
design
of
self‐assembled
compounds
is
crucial
for
the
highly
efficient
development
carrier‐free
nanomedicines.
Herein,
based
on
computer‐aided
strategies,
important
physicochemical
properties
are
identified
to
guide
compounds.
Then,
pharmacophore
hybridization
strategy
used
self‐assemble
nanoparticles
by
preparing
new
chemical
structures
combining
groups
different
bioactive
Hydroxychloroquine
grafted
with
lipophilic
vitamin
E
succinate
and
then
co‐assembled
bortezomib
fabricate
nanoparticle.
nanoparticle
can
reduce
M2‐type
tumor‐associated
macrophages
(TAMs)
through
lysosomal
alkalization
induce
immunogenic
cell
death
(ICD)
nuclear
factor‐κB
(NF‐κB)
inhibition
in
tumor
cells.
In
mouse
models,
decreased
levels
TAMs,
regulatory
T
cells,
transforming
growth
factor‐β
(TGF‐β),
increase
proportion
cytotoxicity
lymphocytes.
Additionally,
secretion
Interleukin‐6
(IL‐6)
inhibiting
NF‐κB
enhance
programmed
ligand‐1
(PD‐L1)
checkpoint
blockade
therapy.
hybridization‐derived
provides
a
dual‐modulation
reprogram
microenvironment,
which
will
efficiently
chemoimmunotherapy
against
triple‐negative
breast
cancer.
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
In
this
study,
a
novel
ASGP-R
targeted
contrast
agent
has
been
developed
for
liver
cancer
diagnosis,
which
exhibits
high
imaging
efficacy
and
great
biosafety,
holding
promise
as
MRI
of
human
cancer.
Future Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 10
Published: Feb. 14, 2025
Background
Upregulation
of
Cyclooxygenase-2
(COX-2)
in
a
variety
cancer
cell
lines,
key
enzyme
prostaglandin
biosynthesis,
relative
to
surrounding
normal
tissues
results
the
use
COX-2
protein
as
an
attractive
molecular
target
for
many
anticancer
therapeutics.
This
could
have
significant
implication
selective
destruction
cells
via
photodynamic
therapy
effects,
leaving
tissue
intact.
