Influence of evening light exposure on polysomnographically assessed night-time sleep: A systematic review with meta-analysis DOI
Christian Cajochen, Oliver Stefani, Isabel Schöllhorn

et al.

Lighting Research & Technology, Journal Year: 2022, Volume and Issue: 54(6), P. 609 - 624

Published: Aug. 5, 2022

Evening exposure to electric light can acutely suppress melatonin levels and adversely affect subsequent sleep. We conducted a systematic review with meta-analysis investigating the influence of evening illuminance on polysomnographically (PSG)-assessed also explored how melanopsin (expressed in melanopic equivalent daylight (EDI) affects human sleep features. included polysomnographic laboratory studies healthy humans for effects duration, pre-sleep exposures between 6:00 p.m. 1:00 a.m. From 440 identified articles, 114 met eligibility criteria screening, 21 reported type source/spectral characteristics, 12 as eligible review. Meta-analysis showed latency, efficiency slow wave sleep, overall effect sizes (95% confidence interval) 0.69 (−0.50; 1.88), 0.34 (−0.13; 0.82) −0.61 (−1.85; 0.62), respectively. Estimated EDI range 100–1000 lx yielded clear dose–response relationships latency efficiency, but not Whilst duration indicated no apparent single PSG-assessed we observed evidence relationship based EDI. Hence, may provide robust predictor non-visual responses

Language: Английский

Melanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior DOI Creative Commons
Michael Tri H.

Neuron, Journal Year: 2019, Volume and Issue: 104(2), P. 205 - 226

Published: Oct. 1, 2019

Language: Английский

Citations

239

Time spent in outdoor light is associated with mood, sleep, and circadian rhythm-related outcomes: A cross-sectional and longitudinal study in over 400,000 UK Biobank participants DOI
A Burns, Richa Saxena, Céline Vetter

et al.

Journal of Affective Disorders, Journal Year: 2021, Volume and Issue: 295, P. 347 - 352

Published: Aug. 26, 2021

Language: Английский

Citations

108

The cognitive impact of light: illuminating ipRGC circuit mechanisms DOI
Heather Mahoney, Tiffany M. Schmidt

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(3), P. 159 - 175

Published: Jan. 26, 2024

Language: Английский

Citations

22

Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions DOI
Marcos L. Aranda, Tiffany M. Schmidt

Cellular and Molecular Life Sciences, Journal Year: 2020, Volume and Issue: 78(3), P. 889 - 907

Published: Sept. 23, 2020

Language: Английский

Citations

133

Circadian depression: A mood disorder phenotype DOI
Joanne S. Carpenter, Jacob J. Crouse, Elizabeth Scott

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 126, P. 79 - 101

Published: March 7, 2021

Language: Английский

Citations

78

Metabolic Implications of Exposure to Light at Night: Lessons from Animal and Human Studies DOI

Giulia Fleury,

Anayanci Masís‐vargas, Andries Kalsbeek

et al.

Obesity, Journal Year: 2020, Volume and Issue: 28(S1)

Published: July 1, 2020

Lately, the incidence of overweight, obesity, and type 2 diabetes has shown a staggering increase. To prevent treat these conditions, one must look at their etiology. As life on earth evolved under conditions nature’s 24‐hour light/dark cycle, it seems likely that exposure to artificial light night (LAN) would affect physiology. Indeed, ample evidence LAN impacts many metabolic parameters, least partly via biological clock in suprachiasmatic nucleus hypothalamus. This review focuses impact chronic acute effects different wavelengths locomotor activity, food intake, sleep/wake body temperature, melatonin, glucocorticoids, glucose lipid metabolism. While disturbs daily rhythms experiments using short‐term also have negative metabolically active peripheral tissues. Experiments not only indicated an important role for melanopsin, photopigment found intrinsically photosensitive retinal ganglion cells, but provided each wavelength may specific energy Importantly, been homeostasis humans be associated with increased atherosclerosis.

Language: Английский

Citations

75

Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing DOI Creative Commons
Gowri Nayak, Kevin Zhang, Shruti Vemaraju

et al.

Cell Reports, Journal Year: 2020, Volume and Issue: 30(3), P. 672 - 686.e8

Published: Jan. 1, 2020

Almost all life forms can detect and decode light information for adaptive advantage. Examples include the visual system, in which photoreceptor signals are processed into virtual images, circadian entrains a physiological clock. Here we describe response pathway mice that employs encephalopsin (OPN3, 480 nm, blue-light-responsive opsin) to regulate function of adipocytes. Germline null adipocyte-specific conditional show light- Opn3-dependent deficit thermogenesis become hypothermic upon cold exposure. We stimulating mouse adipocytes with blue enhances lipolysis and, particular, phosphorylation hormone-sensitive lipase. This is Opn3 dependent. These data establish key mechanism light-dependent, local regulation white regulates energy metabolism.

Language: Английский

Citations

71

Feature Detection by Retinal Ganglion Cells DOI Creative Commons
Daniel Kerschensteiner

Annual Review of Vision Science, Journal Year: 2022, Volume and Issue: 8(1), P. 135 - 169

Published: April 6, 2022

Retinal circuits transform the pixel representation of photoreceptors into feature representations ganglion cells, whose axons transmit these to brain. Functional, morphological, and transcriptomic surveys have identified more than 40 retinal cell (RGC) types in mice. RGCs extract features varying complexity; some simply signal local differences brightness (i.e., luminance contrast), whereas others detect specific motion trajectories. To understand retina, we need know how give rise diverse RGC representations. A catalog set, turn, is fundamental understanding visual processing Anterograde tracing indicates that innervate 50 areas mouse Current maps connecting brain are rudimentary, as our signals transformed downstream guide behavior. In this article, I review selectivities RGCs, they arise, utilized downstream. Not only knowledge behavioral purpose critical for contributions vision; it can also us most relevant space.

Language: Английский

Citations

67

The Complex Effects of Light on Metabolism in Humans DOI Open Access
Asuka Ishihara, Amber B. Courville, Kong Y. Chen

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1391 - 1391

Published: March 14, 2023

Light is an essential part of many life forms. The natural light–dark cycle has been the dominant stimulus for circadian rhythms throughout human evolution. Artificial light restructured activity and provided opportunities to extend day without reliance on day–night cycles. increase in exposure at unwanted times or a reduced dynamic range between daytime nighttime introduced negative consequences health. closely linked sleep–wake regulation, eating patterns, body temperature, energy metabolism. Disruptions these areas due are metabolic abnormalities such as increased risk obesity diabetes. Research revealed that various properties influence This review will highlight complex role physiology, with specific emphasis regulation from perspective four main (intensity, duration, timing exposure, wavelength). We also discuss potential key hormone melatonin sleep physiology. explore relationship metabolism through physiology populations understand optimal use mitigate short long-term health consequences.

Language: Английский

Citations

31

Circadian-independent light regulation of mammalian metabolism DOI
Feng Rao, Tian Xue

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(6), P. 1000 - 1007

Published: June 3, 2024

Language: Английский

Citations

16