The EMBO Journal, Journal Year: 2021, Volume and Issue: 41(4)
Published: Dec. 27, 2021
Language: Английский
Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 9
Published: Jan. 3, 2022
Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the hematopoietic niche, are a group of heterogeneous composed multipotent stem cells, including osteochondral and adipocyte progenitors. Nevertheless, identification classification still controversial, which limits their application. In recent years, by lineage tracing single-cell sequencing, several new subgroups BMSCs roles in normal physiological pathological conditions have been clarified. Key regulators mechanisms controlling fate being revealed. Cross-talk among bone has demonstrated. this review, we focus on advances BMSCs, provides important implications for clinical applications.
Language: Английский
Citations
95
Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(3), P. 386 - 413
Published: March 1, 2023
Language: Английский
Citations
82
Cell, Journal Year: 2024, Volume and Issue: 187(12), P. 3120 - 3140.e29
Published: May 6, 2024
Non-hematopoietic cells are essential contributors to hematopoiesis. However, heterogeneity and spatial organization of these in human bone marrow remain largely uncharacterized. We used single-cell RNA sequencing (scRNA-seq) profile 29,325 non-hematopoietic discovered nine transcriptionally distinct subtypes. simultaneously profiled 53,417 hematopoietic predicted their interactions with subsets. employed co-detection by indexing (CODEX) spatially over 1.2 million cells. integrated scRNA-seq CODEX data link cellular signaling proximity. Our analysis revealed a hyperoxygenated arterio-endosteal neighborhood for early myelopoiesis, an adipocytic localization stem progenitor (HSPCs). our atlas annotate new images uncovered mesenchymal stromal cell (MSC) expansion neighborhoods co-enriched leukemic blasts MSCs acute myeloid leukemia (AML) patient samples. This resolved, multiomic provides reference investigation that drive
Language: Английский
Citations
59
Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(4), P. 667 - 684.e6
Published: April 1, 2023
Language: Английский
Citations
52
Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(7), P. 399 - 413
Published: March 18, 2024
Language: Английский
Citations
32
Endocrine Reviews, Journal Year: 2024, Volume and Issue: 45(5), P. 676 - 708
Published: March 14, 2024
Research on lean, energy-deficient athletic and military cohorts has broadened the concept of Female Athlete Triad into Relative Energy Deficiency in Sport (REDs) syndrome. REDs represents a spectrum abnormalities induced by low energy availability (LEA), which serves as underlying cause all symptoms described within concept, affecting exercising populations either biological sex. Both short- long-term LEA, conjunction with other moderating factors, may produce multitude maladaptive changes that impair various physiological systems adversely affect health, well-being, sport performance. Consequently, comprehensive definition encompasses broad sequelae adverse clinical outcomes related to such neuroendocrine, bone, immune, hematological effects, ultimately resulting compromised health In this review, we discuss pathophysiology associated disorders. We briefly examine current treatment recommendations for REDs, primarily focusing nonpharmacological, behavioral, lifestyle modifications target its cause-energy deficit. also approaches aimed at managing symptoms, menstrual dysfunction bone stress injuries, explore potential novel treatments physiology, emphasizing roles leptin activin-follistatin-inhibin axis, remain be fully elucidated, management REDs. near future, therapies leveraging our emerging understanding molecules axes or lack thereof restore LEA-related abnormalities, thus preventing and/or treating REDs-related complications, fractures, improving
Language: Английский
Citations
17
Journal of Bone and Mineral Research, Journal Year: 2020, Volume and Issue: 35(11), P. 2103 - 2120
Published: Aug. 26, 2020
ABSTRACT Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, secrete angiocrine factors required for the survival, maintenance, self-renewal of stem progenitor cells. In skeletal system, creates nurturing blood-forming Blood vessels regulate hematopoiesis drive formation during development, repair, regeneration. Dysfunctional induce aging, diseases, hematological disorders. Recent cellular molecular characterization microenvironment has provided unprecedented insights into complexity, heterogeneity, functions niches. The is composed distinct vessel subtypes that differentially osteogenesis, hematopoiesis, disease conditions in bones. Further, supporting cells are often complex microenvironments involving multiple different cell populations subtypes. This review provides an overview emerging heterogeneity new roles associated health disease. © 2020 Authors. Journal Mineral Research published by Wiley Periodicals LLC on behalf American Society (ASBMR).
Language: Английский
Citations
108
Journal of Bone and Mineral Research, Journal Year: 2020, Volume and Issue: 36(8), P. 1432 - 1447
Published: Dec. 1, 2020
ABSTRACT Osteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of most important functions these metabolically active is mineralized matrix production. Because osteoblasts have a limited lifespan, they must be constantly replenished by preosteoblasts, their immediate precursors. disruption regulation bone-forming results variety bone diseases, better understanding origin defining mechanisms development, remodeling, and regeneration central development novel therapeutic approaches. In recent years, substantial new insights into osteoblasts—largely owing rapid technological advances murine lineage-tracing approaches other single-cell technologies—have been obtained. Collectively, findings indicate involved formation under various physiological, pathological, conditions obtained from numerous sources. The origins include, but not to, chondrocytes growth plate, stromal marrow, quiescent bone-lining on surface, specialized fibroblasts craniofacial structures, such as sutures periodontal ligaments. generated local cellular sources, flexibly respond regenerative anabolic cues. However, whether derived different sources distinct remains investigated. Currently, we at initial stage aptly unravel incredible diversity osteoblasts. © 2021 American Society for Bone Mineral Research (ASBMR).
Language: Английский
Citations
102
Cell Reports, Journal Year: 2021, Volume and Issue: 36(2), P. 109352 - 109352
Published: July 1, 2021
Bone stroma contributes to the regulation of osteogenesis and hematopoiesis but also fracture healing disease processes. Mesenchymal stromal cells from bone (BMSCs) represent a heterogenous mixture different subpopulations with distinct molecular functional properties. The lineage relationship between BMSC subsets their by intrinsic extrinsic factors are not well understood. Here, we show mouse genetics, ex vivo cell differentiation assays, transcriptional profiling that BMSCs metaphysis (mpMSCs) diaphysis (dpMSCs) fundamentally distinct. Fate-tracking experiments single-cell RNA sequencing indicate bone-forming osteoblast dpMSCs, including leptin receptor-positive (LepR+) reticular in marrow, emerge mpMSCs postnatal metaphysis. Finally, fate is controlled platelet-derived growth factor receptor β (PDGFRβ) signaling transcription Jun-B. sum our findings improves understanding development, relationships, differentiation.
Language: Английский
Citations
79
Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9
Published: March 12, 2021
Single-cell sequencing approaches have transformed our understanding of stem cell systems, including hematopoiesis and its niche within the bone marrow. Recent reports examined marrow microenvironment at single-cell resolution steady state, following chemotherapy treatment, leukemic onset, aging. These rapid advancements significantly informed heterogeneity. However, inconsistent representation nomenclature among studies hinder a comprehensive interpretation this body work. Here, we review recent interrogating architecture present an integrated overview published datasets.
Language: Английский
Citations
72