Stress-induced biological aging: A review and guide for research priorities DOI Creative Commons

Lilian R. Polsky,

Kelly E. Rentscher, Judith Carroll

et al.

Brain Behavior and Immunity, Journal Year: 2022, Volume and Issue: 104, P. 97 - 109

Published: June 1, 2022

Exposure to chronic adverse conditions, and the resultant activation of neurobiological response cascade, has been associated with an increased risk early onset age-related disease and, recently, older biological age. This body research led hypothesis that exposure stressful life experiences, when occurring repeatedly or over a prolonged period, may accelerate rate at which ages. The mechanisms through psychosocial stress influences distinct aging pathways alter rates likely involve multiple layers in physiological-molecular network. In this review, we integrate using animal, human, vitro models begin delineate impact aging, as well neuroendocrine mediators (i.e., norepinephrine, epinephrine, glucocorticoids) drive these effects. Findings highlight key connections between namely cellular metabolic activity, DNA damage, telomere length, senescence, inflammatory patterns. We conclude guiding framework conceptual model outlines most promising by conditions could point missing gaps knowledge where future best answer pressing questions.

Language: Английский

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments DOI Creative Commons
Jun Guo, Xiuqing Huang, Lin Dou

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Dec. 16, 2022

Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue cell functions significant increases the risks of various aging-related diseases, including neurodegenerative cardiovascular metabolic musculoskeletal immune system diseases. Although development modern medicine has promoted human health greatly extended life expectancy, aging society, variety chronic diseases have gradually become most important causes disability death elderly individuals. Current research on focuses elucidating how endogenous exogenous stresses (such as genomic instability, telomere dysfunction, epigenetic alterations, loss proteostasis, compromise autophagy, mitochondrial cellular senescence, stem exhaustion, altered intercellular communication, deregulated nutrient sensing) participate regulation aging. Furthermore, thorough pathogenesis to identify interventions that promote longevity caloric restriction, microbiota transplantation, nutritional intervention) clinical treatment methods for (depletion senescent cells, therapy, antioxidative anti-inflammatory treatments, hormone replacement therapy) could decrease incidence turn healthy longevity.

Language: Английский

Citations

700
DunedinPACE, a DNA methylation biomarker of the pace of aging DOI Creative Commons
Daniel W. Belsky, Avshalom Caspi, David L. Corcoran

et al.

eLife, Journal Year: 2022, Volume and Issue: 11

Published: Jan. 14, 2022

Measures to quantify changes in the pace of biological aging response intervention are needed evaluate geroprotective interventions for humans. Previously, we showed that quantification from a DNA-methylation blood test was possible (Belsky et al., 2020). Here, report next-generation biomarker Pace Aging, DunedinPACE (for Aging Calculated Epigenome).

Language: Английский

Citations

499
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm DOI Creative Commons
Daniel W. Belsky, Avshalom Caspi, Louise Arseneault

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: May 5, 2020

Biological aging is the gradual, progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of pace are needed as surrogate endpoints trials therapies designed to prevent disease by slowing biological aging. We report a blood-DNA-methylation measure sensitive variation among individuals born same year. first modeled change-over-time 18 biomarkers tracking organ-system across 12 years follow-up n = 954 members Dunedin Study 1972–1973. Rates change each biomarker over ages 26–38 were composited form aging-related decline, termed Pace-of-Aging. Elastic-net regression was used develop DNA-methylation predictor Pace-of-Aging, called DunedinPoAm for Dunedin(P)ace(o)f(A)ging(m)ethylation. Validation analysis cohort studies CALERIE trial provide proof-of-principle single-time-point person’s

Language: Английский

Citations

410
Measuring biological age using omics data DOI
Jarod Rutledge, Hamilton Oh, Tony Wyss‐Coray

et al.

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 23(12), P. 715 - 727

Published: June 17, 2022

Language: Английский

Citations

301
Biomarkers of aging for the identification and evaluation of longevity interventions DOI Creative Commons
Mahdi Moqri, Chiara Herzog, Jesse R. Poganik

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(18), P. 3758 - 3775

Published: Aug. 1, 2023

Language: Английский

Citations

262
A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking DOI
Albert Higgins‐Chen, Kyra Thrush, Yunzhang Wang

et al.

Nature Aging, Journal Year: 2022, Volume and Issue: 2(7), P. 644 - 661

Published: July 15, 2022

Language: Английский

Citations

238
Nutrition, longevity and disease: From molecular mechanisms to interventions DOI Creative Commons
Valter D. Longo, Rozalyn M. Anderson

Cell, Journal Year: 2022, Volume and Issue: 185(9), P. 1455 - 1470

Published: April 1, 2022

Diet as a whole, encompassing food composition, calorie intake, and the length frequency of fasting periods, affects time span in which health functional capacity are maintained. Here, we analyze aging nutrition studies simple organisms, rodents, monkeys, humans to link longevity conserved growth metabolic pathways outline their role age-related disease. We focus on feasible nutritional strategies shown delay and/or prevent diseases through epidemiological, model organism, clinical, centenarian underline need avoid malnourishment frailty. These findings integrated define diet based multi-pillar approach adjusted for age status optimize lifespan healthspan humans.

Language: Английский

Citations

222
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy DOI Open Access
Maxwell L. Elliott, Avshalom Caspi, Renate Houts

et al.

Nature Aging, Journal Year: 2021, Volume and Issue: 1(3), P. 295 - 308

Published: March 15, 2021

Language: Английский

Citations

197
Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden DOI Creative Commons
Robert F. Hillary, Anna J. Stevenson, Daniel L. McCartney

et al.

Clinical Epigenetics, Journal Year: 2020, Volume and Issue: 12(1)

Published: July 31, 2020

Abstract Background Individuals of the same chronological age display different rates biological ageing. A number measures have been proposed which harness age-related changes in DNA methylation profiles. These include five ‘epigenetic clocks’ provide an index how much individual’s differs from their at time measurement. The clocks encompass methylation-based predictors (HorvathAge, HannumAge), all-cause mortality (DNAm PhenoAge, DNAm GrimAge) and telomere length Telomere Length). sixth epigenetic measure ageing these that it acts as a speedometer providing single time-point measurement pace This is termed DunedinPoAm. In this study, we test association between six prevalence incidence leading causes disease burden high-income countries ( n ≤ 9537, Generation Scotland: Scottish Family Health Study). Results GrimAge predicted clinically diagnosed chronic obstructive pulmonary (COPD), type 2 diabetes ischemic heart after 13 years follow-up (hazard ratios = 2.22, 1.52 1.41, respectively). DunedinPoAm COPD lung cancer 2.02 1.45, PhenoAge ratio 1.54). Length associated with 0.80). mortality, spirometry study baseline. associations were present adjusting for possible confounding risk factors including alcohol consumption, body mass index, deprivation, education tobacco smoking surpassed stringent Bonferroni-corrected significance thresholds. Conclusions Our data suggest may utility clinical settings to complement gold-standard methods assessment management.

Language: Английский

Citations

155
Associations of Age, Sex, Race/Ethnicity, and Education With 13 Epigenetic Clocks in a Nationally Representative U.S. Sample: The Health and Retirement Study DOI Creative Commons
Eileen M. Crimmins, Bharat Thyagarajan, Morgan E. Levine

et al.

The Journals of Gerontology Series A, Journal Year: 2021, Volume and Issue: 76(6), P. 1117 - 1123

Published: Jan. 16, 2021

Abstract Background Many DNA methylation-based indicators have been developed as summary measures of epigenetic aging. We examine the associations between 13 clocks, including 4 second generation well links clocks to social, demographic, and behavioral factors known be related health outcomes: sex, race/ethnicity, socioeconomic status, obesity, lifetime smoking pack-years. Methods The Health Retirement Study is data source which a nationally representative sample Americans over age 50. Assessment methylation was based on EPIC chip were existing literature. Results vary in strength their relationships with age, each other independent variables. Second trained health-related characteristics tend relate more strongly sociodemographic behaviors associated outcomes this group. Conclusions Users publicly available set should aware that variables process change age.

Language: Английский

Citations

151