Phylogenetically distant animals sleep: why do sleep researchers care? DOI Creative Commons
William Bechtel

Biology & Philosophy, Journal Year: 2023, Volume and Issue: 39(1)

Published: Dec. 29, 2023

Abstract Philosophers examining mechanistic explanations in biology have identified heuristic strategies scientists use discovering mechanisms. This paper examines the strategy of investigating phylogenetically distant model organisms, using research on sleep fruit flies as an example. At time was discovered 2000 next to nothing known about mechanisms regulating and what they could reveal those us. One relatively straightforward line focused homologous genes humans, understand roles their homologs played controlling But other a higher level organization—the neural networks involved homeostatic circadian control sleep. raises puzzle—given that fly vertebrate brains are organized very differently, how regulation serve informative sleep? I argue basic design such can be conserved even composition mechanism changes researchers hope designs deciphered models for understanding humans.

Language: Английский

Interactions of Sleep–Wake History and Circadian Rhythms in Human Sleep DOI
Derk‐Jan Dijk, Anne C. Skeldon

Oxford University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 79 - 86

Published: April 1, 2025

Abstract This chapter describes how sleep is regulated by a process that tracks sleep–wake history and circadian process. It focusses on human studies, but it emphasized many principles of this two-process model for the maintenance homeostasis also apply to animals. reviews empirical fundamentals, conceptual representation, few relevant mechanistic details system. explains separate contributions rhythmicity can be assessed in protocols such as forced desynchrony constant routine protocol. summarizes timing structure well brain function during wakefulness are modulated these two processes. environmental factors light social work schedules influence rhythms. Implications understanding disorders discussed.

Language: Английский

Citations

0
Sleep benefits different stages of memory in Drosophila DOI Creative Commons

Katie Marquand,

Camilla Roselli, Isaac Cervantes-Sandoval

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 19, 2023

Understanding the physiological mechanisms that modulate memory acquisition and consolidation remains among most ambitious questions in neuroscience. Massive efforts have been dedicated to deciphering how experience affects behavior, different sensory phenomena memory. Our ability encode, consolidate retrieve memories depends on internal drives, sleep stands out processes affect memory: one of relatable benefits is aiding occurs order both prepare brain learn new information, after a learning task, those memories. Drosophila lends itself study interactions between sleep. The fruit fly provides incomparable genetic resources, mapped connectome, an existing framework knowledge molecular, cellular, circuit sleep, making remarkable model decipher sophisticated regulation by quantity quality Research has stablished not only facilitates wild-type memory-impaired animals, but deprivation interferes with In addition, it well-accepted paramount processes. Finally, studies shown can promote drive. Nevertheless, molecular network underlying this intertwined relationship are still evasive. Recent work shed light neural substrates mediate sleep-dependent consolidation. similar way, mechanistic insights switch control sleep-independent strategies were recently described. This review will discuss , focusing recent advances field pointing awaiting be investigated.

Language: Английский

Citations

6
The Drosophila circadian clock circuit is a nonhierarchical network of peptidergic oscillators DOI
Sergio L. Crespo-Flores, Annika F. Barber

Current Opinion in Insect Science, Journal Year: 2022, Volume and Issue: 52, P. 100944 - 100944

Published: June 13, 2022

Language: Английский

Citations

9
Dynamics of sleep and feeding homeostasis inDrosophilaglia and neurons DOI Open Access
Andres Flores-Valle,

Ivan Vishniakou,

Johannes D. Seelig

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: July 7, 2022

Abstract Sleep is critical for homeostatic processes in the brain, including metabolism and waste removal. Here, we identify brain-wide, locally acting sleep homeostats short, naturally occurring bouts of Drosophila two major classes glia that arborize inside astrocytes ensheathing glia. We show surround respiratory tracheal tubes, metabolic gas carbon dioxide, changes pH, or behavioral activity, all induce long lasting calcium responses, circadian modulations. Glia describe homeostasis behaving flies more faithfully than previously identified circuits central complex, but a subset neurons fan-shaped body important feeding homeostasis. Local optogenetic activation sufficient to sleep. Together, levels can be modeled as controllers thus establishing link between

Language: Английский

Citations

8
ninna nanna links circadian and homeostatic sleep drive in Drosophila DOI Creative Commons
Anne Petzold, Giorgio F. Gilestro

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Sleep is under control of two processes – circadian and homeo-static regulation but little known about how these integrate. Here, we identify a Drosophila gene, ninna nanna , encoding alternatively spliced isoforms: Ninna Nanna. Both proteins encode aldo-keto reductases are expressed in different, yet interconnected neurons. One isoform, encodes an reductase with predicted affinity for NADP(H) key pacemaker neurons, the s-LN v s. The second NAD(H) ICLI pair wake-promoting peptidergic neurons whose inhibition relieves sleep pressure. interconnect to integrate binary sensing circuit which receives information homeostatic defines archetypal integration drive reinforces hypothesized link between regulation.

Language: Английский

Citations

1
Dynamic neuronal instability generates synaptic plasticity and behavior: Insights from Drosophila sleep DOI Creative Commons
Masashi Tabuchi

Neuroscience Research, Journal Year: 2023, Volume and Issue: 198, P. 1 - 7

Published: June 28, 2023

Language: Английский

Citations

3
Alcohol sensitivity and tolerance encoding in sleep regulatory circadian neurons in Drosophila DOI
Anthony P. Lange, Fred W. Wolf

Addiction Biology, Journal Year: 2023, Volume and Issue: 28(8)

Published: July 4, 2023

Abstract Alcohol tolerance is a simple form of behavioural and neural plasticity that occurs with the first drink. Neural in likely substrate for longer term adaptations can lead to alcohol use disorder. Drosophila develop characteristics similar vertebrates, it useful model determining molecular circuit encoding mechanisms detail. Rapid tolerance, measured after exposure completely metabolized, localized specific brain regions are not interconnected an obvious way. We used forward neuroanatomical screen identify three new sites rapid encoding. One these was composed two groups neurons, DN1a DN1p glutamatergic part circadian clock. neurons regulate arousal by light at night, temperature‐dependent sleep timing, night‐time sleep. Two clock evening activity, LNd6 5th LNv, postsynaptic DN1as, they promote via metabotropic glutamate receptor. Thus, overlaps regulatory circuitry, suggesting mechanistic link.

Language: Английский

Citations

2
Modeling Drosophila sleep: fly in the sky? DOI Creative Commons
Anne C. Skeldon, Derk‐Jan Dijk

SLEEP, Journal Year: 2023, Volume and Issue: 47(2)

Published: Dec. 9, 2023

Language: Английский

Citations

2
Four SpsP neurons are an integrating sleep regulation hub in Drosophila DOI Creative Commons
Xihuimin Dai, Jasmine Quynh Le, Dingbang Ma

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract Sleep is an essential and conserved behavior, yet the mechanisms underlying sleep regulation remain largely unknown. To address neural of drive, here we carry out whole brain calcium-modulated photoactivatable ratiometric integrator (CaMPARI) imaging Drosophila show that activity protocerebral bridge (PB), a part central complex, correlates with drive. Through activation screen followed by anatomical functional connectivity assays, further narrow down key player in PB to three-layer circuit composed 4 SpsP neurons their upstream downstream synaptic partners: act as integrating hub responding ellipsoid body (EB) signals from EPG neurons, sending back EB through PEcG neurons. Moreover, deprivation enriches presynaptic active zones strengthens connections EPG-SpsP-PEcG circuit, indicating plasticity gating response drive change. As also receive input sensorimotor region given known role navigation, these potentially integrate other cues. The data taken together indicate four regulatory play important dynamic regulation.

Language: Английский

Citations

0
Four SpsP neurons are an integrating sleep regulation hub in Drosophila DOI Creative Commons
Xihuimin Dai, Jasmine Quynh Le, Dingbang Ma

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(47)

Published: Nov. 22, 2024

Sleep is essential and highly conserved, yet its regulatory mechanisms remain largely unknown. To identify sleep drive neurons, we imaged Drosophila brains with calcium-modulated photoactivatable ratiometric integrator (CaMPARI). The results indicate that the activity of protocerebral bridge (PB) correlates drive. We further identified a key three-layer PB circuit, EPG-SpsP-PEcG, in which four SpsP neurons respond to ellipsoid body (EB) signals from EPG send back EB through PEcG neurons. This circuit strengthened by deprivation, indicating plasticity response also receive inputs sensorimotor brain region, suggesting they may encode integrating navigation cues. Together, our experiments show their play an important dynamic role regulation.

Language: Английский

Citations

0