International Journal of Computer Vision,
Journal Year:
2022,
Volume and Issue:
131(3), P. 813 - 833
Published: Dec. 19, 2022
Abstract
Relating
behavior
to
brain
activity
in
animals
is
a
fundamental
goal
neuroscience,
with
practical
applications
building
robust
brain-machine
interfaces.
However,
the
domain
gap
between
individuals
major
issue
that
prevents
training
of
general
models
work
on
unlabeled
subjects.
Since
3D
pose
data
can
now
be
reliably
extracted
from
multi-view
video
sequences
without
manual
intervention,
we
propose
use
it
guide
encoding
neural
action
representations
together
set
and
behavioral
augmentations
exploiting
properties
microscopy
imaging.
To
test
our
method,
collect
large
dataset
features
flies
their
activity.
reduce
gap,
during
training,
mix
across
seem
performing
similar
actions.
show
method
generalize
further
modalities
other
downstream
tasks,
human
Electrocorticography
dataset,
another
RGB
activities
different
viewpoints.
We
believe
will
enable
more
decoding
algorithms
used
future
In
most
animals,
a
relatively
small
number
of
descending
neurons
(DNs)
connect
higher
brain
centers
in
the
animal’s
head
to
circuits
and
motor
(MNs)
nerve
cord
body
that
effect
movement
limbs.
To
understand
how
signals
generate
behavior,
it
is
critical
these
pathways
are
organized
onto
MNs.
fly,
Drosophila
melanogaster
,
MNs
controlling
muscles
leg,
wing,
other
systems
reside
ventral
(VNC),
analogous
mammalian
spinal
cord.
companion
papers,
we
introduced
densely-reconstructed
connectome
Male
Adult
Nerve
Cord
(MANC,
Takemura
et
al.,
2023),
including
cell
type
developmental
lineage
annotation
(Marin
which
provides
complete
VNC
connectivity
at
synaptic
resolution.
Here,
present
first
look
organization
networks
connecting
DNs
based
on
this
new
information.
We
proofread
curated
all
ensure
accuracy
reliability,
then
systematically
matched
DN
axon
terminals
MN
dendrites
with
light
microscopy
data
link
their
morphology
inputs
or
muscle
targets.
report
both
broad
organizational
patterns
entire
network
fine-scale
analysis
selected
interest.
discover
direct
DN-MN
connections
infrequent
identify
communities
intrinsic
linked
control
different
systems,
putative
for
walking,
dorsal
flight
steering
power
generation,
intermediate
lower
tectulum
coordinated
action
wings
legs.
Our
generates
hypotheses
future
functional
experiments
and,
together
MANC
connectome,
empowers
others
investigate
richer
mechanistic
detail.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2020,
Volume and Issue:
unknown
Published: April 5, 2020
Abstract
Orienting
behaviors
provide
a
continuous
stream
of
information
about
an
organism’s
sensory
experiences
and
plans.
Thus,
to
study
the
links
between
sensation
action,
it
is
useful
identify
neurons
in
brain
that
control
orienting
behaviors.
Here
we
describe
descending
Drosophila
predict
influence
orientation
(heading)
during
walking.
We
show
these
cells
have
specialized
functions:
whereas
one
cell
type
predicts
sustained
low-gain
steering,
other
transient
high-gain
steering.
These
latter
integrate
internally-directed
steering
signals
from
head
direction
system
with
stimulus-directed
multimodal
pathways.
The
inputs
are
organized
produce
“see-saw”
commands,
so
increasing
output
hemisphere
accompanied
by
decreasing
hemisphere.
Together,
our
results
internal
external
drives
integrated
motor
commands
different
timescales,
for
flexible
precise
space.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 7, 2023
Abstract
In
most
animals,
a
relatively
small
number
of
descending
neurons
(DNs)
connect
higher
brain
centers
in
the
animal’s
head
to
circuits
and
motor
(MNs)
nerve
cord
body
that
effect
movement
limbs.
To
understand
how
signals
generate
behavior,
it
is
critical
these
pathways
are
organized
onto
MNs.
fly,
Drosophila
melanogaster
,
MNs
controlling
muscles
leg,
wing,
other
systems
reside
ventral
(VNC),
analogous
mammalian
spinal
cord.
companion
papers,
we
introduced
densely-reconstructed
connectome
Male
Adult
Nerve
Cord
(MANC,
Takemura
et
al.,
2023),
including
cell
type
developmental
lineage
annotation
(Marin
which
provides
complete
VNC
connectivity
at
synaptic
resolution.
Here,
present
first
look
organization
networks
connecting
DNs
based
on
this
new
information.
We
proofread
curated
all
ensure
accuracy
reliability,
then
systematically
matched
DN
axon
terminals
MN
dendrites
with
light
microscopy
data
link
their
morphology
inputs
or
muscle
targets.
report
both
broad
organizational
patterns
entire
network
fine-scale
analysis
selected
interest.
discover
direct
DN-MN
connections
infrequent
identify
communities
intrinsic
linked
control
different
systems,
putative
for
walking,
dorsal
flight
steering
power
generation,
intermediate
lower
tectulum
coordinated
action
wings
legs.
Our
generates
hypotheses
future
functional
experiments
and,
together
MANC
connectome,
empowers
others
investigate
richer
mechanistic
detail.
Journal of Comparative Physiology A,
Journal Year:
2023,
Volume and Issue:
209(4), P. 467 - 488
Published: Jan. 20, 2023
Abstract
Using
odors
to
find
food
and
mates
is
one
of
the
most
ancient
highly
conserved
behaviors.
Arthropods
from
flies
moths
crabs
use
broadly
similar
strategies
navigate
toward
odor
sources—such
as
integrating
flow
information
with
information,
comparing
concentration
across
sensors,
over
time.
Because
arthropods
share
many
homologous
brain
structures—antennal
lobes
for
processing
olfactory
mechanosensors
flow,
mushroom
bodies
(or
hemi-ellipsoid
bodies)
associative
learning,
central
complexes
navigation,
it
likely
that
these
closely
related
behaviors
are
mediated
by
neural
circuits.
However,
differences
in
types
they
seek,
physics
dispersal,
locomotion
water,
air,
on
substrates
mean
circuits
must
have
adapted
generate
a
wide
diversity
odor-seeking
In
this
review,
we
discuss
common
specializations
observed
navigation
behavior
arthropods,
review
our
current
knowledge
about
subserving
behavior.
We
propose
comparative
study
arthropod
nervous
systems
may
provide
insight
into
how
set
basic
circuit
structures
has
diversified
different
environments.
Nature,
Journal Year:
2024,
Volume and Issue:
630(8017), P. 686 - 694
Published: June 5, 2024
Abstract
To
convert
intentions
into
actions,
movement
instructions
must
pass
from
the
brain
to
downstream
motor
circuits
through
descending
neurons
(DNs).
These
include
small
sets
of
command-like
that
are
sufficient
drive
behaviours
1
—the
circuit
mechanisms
for
which
remain
unclear.
Here
we
show
DNs
in
Drosophila
directly
recruit
networks
additional
orchestrate
require
active
control
numerous
body
parts.
Specifically,
found
previously
thought
alone
2–4
fact
co-activate
larger
populations
DNs.
Connectome
analyses
and
experimental
manipulations
revealed
this
functional
recruitment
can
be
explained
by
direct
excitatory
connections
between
interconnected
brain.
Descending
population
is
necessary
behavioural
control:
with
many
partners
network
co-activation
complete
only
simple
stereotyped
movements
their
absence.
DN
reside
within
behaviour-specific
clusters
inhibit
one
another.
results
support
a
mechanism
generated
increasingly
large
compose
combining
multiple
subroutines.
