Context-dependence of deterministic and nondeterministic contributions to closed-loop steering control DOI Creative Commons

Seth W. Egger,

Sander W. Keemink, Mark S. Goldman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract In natural circumstances, sensory systems operate in a closed loop with motor output, whereby actions shape subsequent experiences. A prime example of this is the sensorimotor processing required to align one’s direction travel, or heading, goal, behavior we refer as steering. steering, outputs work eliminate errors between heading and modifying process. The closed-loop nature makes it challenging determine how deterministic nondeterministic processes contribute behavior. We overcome by applying nonparametric, linear kernel-based analysis behavioral data monkeys steering through virtual environment two experimental contexts. given context, results were consistent previous that described transformation second-order system. Classically, parameters such models are associated physical properties limb viscosity stiffness commonly assumed be approximately constant. By contrast, found fit kernels differed strongly across tasks these other parameters, suggesting context-dependent changes neural biomechanical processes. additionally residuals simple noise model form was highly conserved both contexts animals. Strikingly, fitted also closely matched previously human task. Altogether, presents characterizes context-dependence non-deterministic components New noteworthy use nonparametric identification techniques assess contributions Classical approaches assume fixed input output. Here, reveal strong measured transformations context. within exhibited contexts, subjects, species. Together, demonstrates context affects systematic stochastic

Language: Английский

Interactions between circuit architecture and plasticity in a closed-loop cerebellar system DOI Creative Commons
Hannah L. Payne, Jennifer L Raymond, Mark S. Goldman

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: March 7, 2024

Determining the sites and directions of plasticity underlying changes in neural activity behavior is critical for understanding mechanisms learning. Identifying such from recording data can be challenging due to feedback pathways that impede reasoning about cause effect. We studied interactions between feedback, activity, context a closed-loop motor learning task which there disagreement loci plasticity: vestibulo-ocular reflex constructed set circuit models differed strength their recurrent no very strong feedback. Despite these differences, each model successfully fit large behavioral data. However, patterns predicted by fundamentally differed, with direction at key site changing depression potentiation as increased. Guided our analysis, we suggest how experimentally disambiguated. Our results address long-standing debate regarding cerebellum-dependent learning, suggesting reconciliation learning-related synaptic inputs Purkinje cells are compatible seemingly oppositely directed cell spiking activity. More broadly, demonstrate over appear contradict sign when either internal or through environment present.

Language: Английский

Citations

7
Cerebellar Roles in Motor and Social Functions and Implications for ASD DOI
Azhagu Madhavan Sivalingam, Arjun Pandian

The Cerebellum, Journal Year: 2024, Volume and Issue: 23(6), P. 2564 - 2574

Published: July 17, 2024

Language: Английский

Citations

4
Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function DOI Creative Commons
Brandon J. Bhasin, Jennifer L Raymond, Mark S. Goldman

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(41)

Published: Oct. 4, 2024

Systems consolidation is a common feature of learning and memory systems, in which long-term initially stored one brain region becomes persistently another region. We studied the dynamics systems simple circuit architectures with two sites plasticity, an early-learning late-learning area. show that synaptic during analog can be understood as temporal integration process, by transient changes activity driven plasticity area are accumulated into persistent at site. This principle naturally leads to speed-accuracy tradeoff provides insight how mitigates stability-plasticity dilemma storing new memories while preserving core features older ones. Furthermore, it imposes constraints on circuit. First, rule site must stably support continuum possible outputs for given input. this readily achieved heterosynaptic but not standard Hebbian rules. Second, turn off process prevent erroneous site, neural reset its baseline activity. provide biologically plausible implementations propose functional roles stabilizing elements cerebellar

Language: Английский

Citations

4
In vivo imaging of inferior olive neurons reveals roles of co-activation and cerebellar feedback in olivocerebellar signaling DOI Open Access
Da Guo, Marylka Yoe Uusisaari

Published: Feb. 27, 2025

Complex spikes (CSs), generated by inferior olive (IO) neurons, are foundational to most theories of cerebellar function and motor learning. Despite their importance, recordings from IO neurons in living animals have been limited single-electrode methods, providing no insights into multineuron dynamics within intact circuits. Here, we used a novel ventral surgical approach that allows calcium imaging-based monitoring multicellular activity the anesthetized mice. This method provides direct optical access medulla, enabling simultaneous recording spontaneous sensory-evoked localized clusters specifically principal (PO) dorsal accessory olives (DAO).Our findings reveal rates event magnitudes differ between PO DAO, consistent with observations cortex zebrin-positive (Z+) zebrin-negative (Z-) zones, respectively. We further demonstrate amplitudes influenced co-activation among neighboring so events occurring larger than single ones. Event is more pronounced potentially explaining differences complex spike sizes observed Z+ Z-zones. Sensory-evoked induced periocular airpuff stimulation were ones, as expected. However, this difference diminishes when accounting for higher levels during sensory stimulation. By comparing categorized clustered or single, find intrinsic amplitudes, emphasizing role shaping magnitude. Next, optogenetically activated nucleo-olivary (N-O) axons, pathway central CS generation. To our surprise, while robustly suppressed activity, showed reduction either probability waveform. Our suggest traditional view N-O purely inhibitory desynchronizing might be complemented selective suppression background preserving sensory-driven responses. Together local magnitudes, work offers new insight timing variation functional significance behavior.

Language: Английский

Citations

0
In vivo imaging of inferior olive neurons reveals roles of co-activation and cerebellar feedback in olivocerebellar signaling DOI Open Access
Da Guo, Marylka Yoe Uusisaari

Published: Feb. 27, 2025

Complex spikes (CSs), generated by inferior olive (IO) neurons, are foundational to most theories of cerebellar function and motor learning. Despite their importance, recordings from IO neurons in living animals have been limited single-electrode methods, providing no insights into multineuron dynamics within intact circuits. Here, we used a novel ventral surgical approach that allows calcium imaging-based monitoring multicellular activity the anesthetized mice. This method provides direct optical access medulla, enabling simultaneous recording spontaneous sensory-evoked localized clusters specifically principal (PO) dorsal accessory olives (DAO).Our findings reveal rates event magnitudes differ between PO DAO, consistent with observations cortex zebrin-positive (Z+) zebrin-negative (Z-) zones, respectively. We further demonstrate amplitudes influenced co-activation among neighboring so events occurring larger than single ones. Event is more pronounced potentially explaining differences complex spike sizes observed Z+ Z-zones. Sensory-evoked induced periocular airpuff stimulation were ones, as expected. However, this difference diminishes when accounting for higher levels during sensory stimulation. By comparing categorized clustered or single, find intrinsic amplitudes, emphasizing role shaping magnitude. Next, optogenetically activated nucleo-olivary (N-O) axons, pathway central CS generation. To our surprise, while robustly suppressed activity, showed reduction either probability waveform. Our suggest traditional view N-O purely inhibitory desynchronizing might be complemented selective suppression background preserving sensory-driven responses. Together local magnitudes, work offers new insight timing variation functional significance behavior.

Language: Английский

Citations

0
Synaptic weight dynamics underlying systems consolidation of a memory DOI Creative Commons
Brandon J. Bhasin, Jennifer L Raymond, Mark S. Goldman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 25, 2024

Abstract Systems consolidation is a common feature of learning and memory systems, in which long-term initially stored one brain region becomes persistently another region. We studied the dynamics systems simple circuit architectures with two sites plasticity, an early-learning late-learning area. show that synaptic during analog can be understood as temporal integration process, by transient changes activity driven plasticity area are accumulated into persistent at site. This principle naturally leads to speed-accuracy tradeoff provides insight how mitigates stability-plasticity dilemma storing new memories while preserving core features older ones. Furthermore, it imposes constraints on circuit. First, rule site must stably support continuum possible outputs for given input. this readily achieved heterosynaptic but not standard Hebbian rules. Second, turn off process prevent erroneous site, neural reset its baseline activity. propose biologically plausible implementations suggest novel roles elements cerebellar Significance Statement How transformed over time? organizing long term moved from initial final storage. successful transfer occurs when late storage endowed rules accumulate occurring early instantiate computational model representative circuits underlying variety behaviors. The suggests store ones,

Language: Английский

Citations

2
Context-dependence of deterministic and nondeterministic contributions to closed-loop steering control DOI Creative Commons

Seth W. Egger,

Sander W. Keemink, Mark S. Goldman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

Abstract In natural circumstances, sensory systems operate in a closed loop with motor output, whereby actions shape subsequent experiences. A prime example of this is the sensorimotor processing required to align one’s direction travel, or heading, goal, behavior we refer as steering. steering, outputs work eliminate errors between heading and modifying process. The closed-loop nature makes it challenging determine how deterministic nondeterministic processes contribute behavior. We overcome by applying nonparametric, linear kernel-based analysis behavioral data monkeys steering through virtual environment two experimental contexts. given context, results were consistent previous that described transformation second-order system. Classically, parameters such models are associated physical properties limb viscosity stiffness commonly assumed be approximately constant. By contrast, found fit kernels differed strongly across tasks these other parameters, suggesting context-dependent changes neural biomechanical processes. additionally residuals simple noise model form was highly conserved both contexts animals. Strikingly, fitted also closely matched previously human task. Altogether, presents characterizes context-dependence non-deterministic components New noteworthy use nonparametric identification techniques assess contributions Classical approaches assume fixed input output. Here, reveal strong measured transformations context. within exhibited contexts, subjects, species. Together, demonstrates context affects systematic stochastic

Language: Английский

Citations

0