Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions DOI Creative Commons
Ahmadreza Keihani,

Claudio Sanguineti,

Omeed Chaichian

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 1095 - 1095

Published: Oct. 30, 2024

Non-invasive brain stimulation (NIBS) techniques are designed to precisely and selectively target specific regions, thus enabling focused modulation of neural activity. Among NIBS technologies, low-intensity transcranial ultrasound (tFUS) has emerged as a promising new modality. The application tFUS can safely non-invasively stimulate deep structures with millimetric precision, offering distinct advantages in terms accessibility non-cortical regions over other methods. However, date, several aspects still need be characterized; furthermore, there only handful studies that have utilized psychiatric populations. This narrative review provides an up-to-date overview key this technique, including the main components system, neuronavigational tools used simulations optimize parameters delivery tFUS, experimental protocols employed evaluate efficacy disorders. findings from populations presented discussed, future directions highlighted.

Language: Английский

Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology DOI

Keith R. Murphy,

Jordan S. Farrell, Jonas Bendig

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(19), P. 3252 - 3266.e5

Published: July 29, 2024

Language: Английский

Citations

24
A practical guide to transcranial ultrasonic stimulation from the IFCN-endorsed ITRUSST consortium DOI Creative Commons

Keith R. Murphy,

Tulika Nandi, Benjamin R. Kop

et al.

Clinical Neurophysiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

5
The relationship between parameters and effects in transcranial ultrasonic stimulation. DOI Creative Commons
Tulika Nandi, Benjamin R. Kop,

Kim Butts Pauly

et al.

Brain stimulation, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

11
Individualized non-invasive deep brain stimulation of the basal ganglia using transcranial ultrasound stimulation DOI Creative Commons
Ghazaleh Darmani, Hamidreza Ramezanpour, Can Sarica

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 19, 2025

Transcranial ultrasound stimulation (TUS) offers precise, non-invasive neuromodulation, though its impact on human deep brain structures remains underexplored. Here we examined TUS-induced changes in the basal ganglia of 10 individuals with movement disorders (Parkinson's disease and dystonia) 15 healthy participants. Local field potentials were recorded using (DBS) leads globus pallidus internus (GPi). Compared to sham, theta burst TUS (tbTUS) increased power during stimulation, while Hz enhanced beta power, effects lasting up 40 min. In participants, a stop-signal task assessed tbTUS GPi, pulvinar serving as an active sham. GPi prolonged reaction times, indicating impaired response inhibition, whereas had no effect. These findings provide direct electrophysiological evidence target engagement specificity structures, suggesting potential noninvasive DBS strategy for neurological psychiatric disorders. is method modulate activity. Using recordings from implanted electrodes, showed that engages internus, neural oscillations behavior.

Language: Английский

Citations

2
Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans DOI Creative Commons
Benjamin R. Kop, Yazan Shamli Oghli, Talyta Grippe

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Oct. 2, 2023

Transcranial ultrasonic stimulation (TUS) is rapidly emerging as a promising non-invasive neuromodulation technique. TUS already well-established in animal models, providing foundations to now optimize neuromodulatory efficacy for human applications. Across multiple studies, one protocol, pulsed at 1000 Hz, has consistently resulted motor cortical inhibition humans (Fomenko et al., 2020). At the same time, parallel research line highlighted potentially confounding influence of peripheral auditory arising from pulsing audible frequencies. In this study, we disentangle direct and indirect contributions inhibitory effects TUS. To end, include tightly matched control conditions across four experiments, preregistered, conducted independently three institutions. We employed combined transcranial magnetic paradigm, where TMS-elicited motor-evoked potentials (MEPs) served an index corticospinal excitability. First, replicated but showed through both tight controls manipulation intensity, duration, masking that was driven by stimulation, not neuromodulation. Furthermore, consider beyond driving overall excitation/inhibition show preliminary evidence how might interact with ongoing neural dynamics instead. Primarily, study highlights substantial shortcomings accounting confound prior TUS-TMS work only flip-over sham no active used. The field must critically reevaluate previous findings given demonstrated impact confounds. rigorous experimental design via (in)active required make substantiated claims future studies. Only when are disentangled those confounds can fully realize its potential clinical

Language: Английский

Citations

19
Effects of focused ultrasound in a “clean” mouse model of ultrasonic neuromodulation DOI Creative Commons
Hongsun Guo, Hossein Salahshoor, Di Wu

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(12), P. 108372 - 108372

Published: Nov. 1, 2023

Highlights•A "clean" mouse model minimizes off-target auditory effects of UNM•Increasing FUS pressure induces thermal and/or non-auditory confounds•Intense elicits spreading and destructive brain depolarization•Direct cortical activation is not observed with the tested parametersSummaryRecent studies on ultrasonic neuromodulation (UNM) in rodents have shown that focused ultrasound (FUS) can activate peripheral pathways, leading to brain-wide excitation, which obscures direct target area by FUS. To address this issue, we developed a new model, double transgenic Pou4f3+/DTR × Thy1-GCaMP6s, allows for inducible deafening using diphtheria toxin UNM while allowing neural activity be visualized fluorescent calcium imaging. Using found confounds caused significantly reduced or eliminated within certain range. At higher pressures, result focal fluorescence dips at target, elicit sensory confounds, damage tissue, depolarization. Under acoustic conditions tested, did observe responses cortex. Our findings provide cleaner animal sonogenetics research, establish parameter range are confidently avoided, reveal side higher-pressure stimulation.Graphical abstract

Language: Английский

Citations

13
Noninvasive intervention by transcranial ultrasound stimulation: Modulation of neural circuits and its clinical perspectives DOI Creative Commons
Takahiro Osada, Seiki Konishi

Psychiatry and Clinical Neurosciences, Journal Year: 2024, Volume and Issue: 78(5), P. 273 - 281

Published: March 20, 2024

Low‐intensity focused transcranial ultrasound stimulation (TUS) is an emerging noninvasive technique capable of stimulating both the cerebral cortex and deep brain structures with high spatial precision. This method recognized for its potential to comprehensively perturb various regions, enabling modulation neural circuits, in a manner not achievable through conventional magnetic or electrical techniques. The underlying mechanisms neuromodulation are based on phenomenon where mechanical waves kinetically interact neurons, specifically affecting neuronal membranes mechanosensitive channels. interaction induces alterations excitability neurons within stimulated region. In this review, we briefly present fundamental principles physics physiological TUS neuromodulation. We explain experimental apparatus procedures humans. Due focality, integration methods, including resonance imaging resonance–guided neuronavigation systems, important perform experiments precise targeting. then review current state literature neuromodulation, particular focus human subjects, targeting subcortical structures. Finally, outline future perspectives clinical applications psychiatric neurological fields.

Language: Английский

Citations

5
The future of transcranial ultrasound as a precision brain interface DOI Creative Commons

Keith E. Murphy,

Elsa Fouragnan

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(10), P. e3002884 - e3002884

Published: Oct. 29, 2024

Our understanding of brain circuit operations and disorders has rapidly outpaced our ability to intervene restore them. Developing technologies that can precisely interface with any region may combine diagnostics therapeutic intervention, expediting personalised medicine. Transcranial ultrasound stimulation (TUS) is a promising noninvasive solution this challenge, offering focal precision scalability. By exploiting the biomechanics pressure waves on tissue, TUS enables multi-site targeted neuromodulation across distributed circuits in cortex deeper areas alike. In Essay, we explore emergent evidence functionally test modify dysfunctional regions, effectively serving as search rescue tool for brain. We define challenges opportunities faced by it moves towards greater target integration advanced monitoring interventional technology. Finally, propose roadmap evolution progresses from research clinically validated disorders.

Language: Английский

Citations

5
Low-intensity focused ultrasound for human neuromodulation DOI
Wynn Legon, Andrew Strohman

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: Dec. 19, 2024

Language: Английский

Citations

5
High-throughput ultrasound neuromodulation in awake and freely behaving rats DOI Creative Commons
Tommaso Di Ianni,

Kyle P. Morrison,

Brenda Yu

et al.

Brain stimulation, Journal Year: 2023, Volume and Issue: 16(6), P. 1743 - 1752

Published: Nov. 1, 2023

Transcranial ultrasound neuromodulation is a promising potential therapeutic tool for the noninvasive treatment of neuropsychiatric disorders. However, expansive parameter space and difficulties in controlling peripheral auditory effects make it challenging to identify sequences brain targets that may provide efficacy. Careful preclinical investigations clinically relevant behavioral models are critically needed suitable acoustic parameters. there lack devices allowing multi-target experimental awake unrestrained rodents. We developed miniaturized 64-element array enables neurointerventional with within-trial active control freely behaving rats. first characterized field free-water transcranial propagation measurements. then confirmed vivo can target multiple regions via electronic steering, verified wearing device does not cause any significant impairments animal motility. Finally, we demonstrated performance our system high-throughput experiment, where found stimulation rat central medial thalamus, but an target, promotes arousal increases locomotor activity.

Language: Английский

Citations

11