Brain stimulation, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Neuron, Journal Year: 2024, Volume and Issue: 112(19), P. 3252 - 3266.e5
Published: July 29, 2024
Language: Английский
Citations
23
Clinical Neurophysiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
5
Brain stimulation, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Citations
11
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 19, 2025
Transcranial ultrasound stimulation (TUS) offers precise, non-invasive neuromodulation, though its impact on human deep brain structures remains underexplored. Here we examined TUS-induced changes in the basal ganglia of 10 individuals with movement disorders (Parkinson's disease and dystonia) 15 healthy participants. Local field potentials were recorded using (DBS) leads globus pallidus internus (GPi). Compared to sham, theta burst TUS (tbTUS) increased power during stimulation, while Hz enhanced beta power, effects lasting up 40 min. In participants, a stop-signal task assessed tbTUS GPi, pulvinar serving as an active sham. GPi prolonged reaction times, indicating impaired response inhibition, whereas had no effect. These findings provide direct electrophysiological evidence target engagement specificity structures, suggesting potential noninvasive DBS strategy for neurological psychiatric disorders. is method modulate activity. Using recordings from implanted electrodes, showed that engages internus, neural oscillations behavior.
Language: Английский
Citations
2
eLife, Journal Year: 2023, Volume and Issue: 12
Published: Oct. 2, 2023
Transcranial ultrasonic stimulation (TUS) is rapidly emerging as a promising non-invasive neuromodulation technique. TUS already well-established in animal models, providing foundations to now optimize neuromodulatory efficacy for human applications. Across multiple studies, one protocol, pulsed at 1000 Hz, has consistently resulted motor cortical inhibition humans (Fomenko et al., 2020). At the same time, parallel research line highlighted potentially confounding influence of peripheral auditory arising from pulsing audible frequencies. In this study, we disentangle direct and indirect contributions inhibitory effects TUS. To end, include tightly matched control conditions across four experiments, preregistered, conducted independently three institutions. We employed combined transcranial magnetic paradigm, where TMS-elicited motor-evoked potentials (MEPs) served an index corticospinal excitability. First, replicated but showed through both tight controls manipulation intensity, duration, masking that was driven by stimulation, not neuromodulation. Furthermore, consider beyond driving overall excitation/inhibition show preliminary evidence how might interact with ongoing neural dynamics instead. Primarily, study highlights substantial shortcomings accounting confound prior TUS-TMS work only flip-over sham no active used. The field must critically reevaluate previous findings given demonstrated impact confounds. rigorous experimental design via (in)active required make substantiated claims future studies. Only when are disentangled those confounds can fully realize its potential clinical
Language: Английский
Citations
19
iScience, Journal Year: 2023, Volume and Issue: 26(12), P. 108372 - 108372
Published: Nov. 1, 2023
Highlights•A "clean" mouse model minimizes off-target auditory effects of UNM•Increasing FUS pressure induces thermal and/or non-auditory confounds•Intense elicits spreading and destructive brain depolarization•Direct cortical activation is not observed with the tested parametersSummaryRecent studies on ultrasonic neuromodulation (UNM) in rodents have shown that focused ultrasound (FUS) can activate peripheral pathways, leading to brain-wide excitation, which obscures direct target area by FUS. To address this issue, we developed a new model, double transgenic Pou4f3+/DTR × Thy1-GCaMP6s, allows for inducible deafening using diphtheria toxin UNM while allowing neural activity be visualized fluorescent calcium imaging. Using found confounds caused significantly reduced or eliminated within certain range. At higher pressures, result focal fluorescence dips at target, elicit sensory confounds, damage tissue, depolarization. Under acoustic conditions tested, did observe responses cortex. Our findings provide cleaner animal sonogenetics research, establish parameter range are confidently avoided, reveal side higher-pressure stimulation.Graphical abstract
Language: Английский
Citations
13
Psychiatry and Clinical Neurosciences, Journal Year: 2024, Volume and Issue: 78(5), P. 273 - 281
Published: March 20, 2024
Low‐intensity focused transcranial ultrasound stimulation (TUS) is an emerging noninvasive technique capable of stimulating both the cerebral cortex and deep brain structures with high spatial precision. This method recognized for its potential to comprehensively perturb various regions, enabling modulation neural circuits, in a manner not achievable through conventional magnetic or electrical techniques. The underlying mechanisms neuromodulation are based on phenomenon where mechanical waves kinetically interact neurons, specifically affecting neuronal membranes mechanosensitive channels. interaction induces alterations excitability neurons within stimulated region. In this review, we briefly present fundamental principles physics physiological TUS neuromodulation. We explain experimental apparatus procedures humans. Due focality, integration methods, including resonance imaging resonance–guided neuronavigation systems, important perform experiments precise targeting. then review current state literature neuromodulation, particular focus human subjects, targeting subcortical structures. Finally, outline future perspectives clinical applications psychiatric neurological fields.
Language: Английский
Citations
5
PLoS Biology, Journal Year: 2024, Volume and Issue: 22(10), P. e3002884 - e3002884
Published: Oct. 29, 2024
Our understanding of brain circuit operations and disorders has rapidly outpaced our ability to intervene restore them. Developing technologies that can precisely interface with any region may combine diagnostics therapeutic intervention, expediting personalised medicine. Transcranial ultrasound stimulation (TUS) is a promising noninvasive solution this challenge, offering focal precision scalability. By exploiting the biomechanics pressure waves on tissue, TUS enables multi-site targeted neuromodulation across distributed circuits in cortex deeper areas alike. In Essay, we explore emergent evidence functionally test modify dysfunctional regions, effectively serving as search rescue tool for brain. We define challenges opportunities faced by it moves towards greater target integration advanced monitoring interventional technology. Finally, propose roadmap evolution progresses from research clinically validated disorders.
Language: Английский
Citations
5
Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)
Published: Dec. 19, 2024
Language: Английский
Citations
5
Brain stimulation, Journal Year: 2023, Volume and Issue: 16(6), P. 1743 - 1752
Published: Nov. 1, 2023
Transcranial ultrasound neuromodulation is a promising potential therapeutic tool for the noninvasive treatment of neuropsychiatric disorders. However, expansive parameter space and difficulties in controlling peripheral auditory effects make it challenging to identify sequences brain targets that may provide efficacy. Careful preclinical investigations clinically relevant behavioral models are critically needed suitable acoustic parameters. there lack devices allowing multi-target experimental awake unrestrained rodents. We developed miniaturized 64-element array enables neurointerventional with within-trial active control freely behaving rats. first characterized field free-water transcranial propagation measurements. then confirmed vivo can target multiple regions via electronic steering, verified wearing device does not cause any significant impairments animal motility. Finally, we demonstrated performance our system high-throughput experiment, where found stimulation rat central medial thalamus, but an target, promotes arousal increases locomotor activity.
Language: Английский
Citations
11