Quercetin and Astragaloside IV Mitigate the Developmental Abnormalities Induced by Gestational Exposure to Zinc Oxide Nanoparticles DOI Creative Commons
Linong Ji,

Qiuru Huang,

Yujuan Qi

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(48), P. 47802 - 47810

Published: Nov. 19, 2024

Zinc oxide (ZnO) nanoparticles (NPs) are extensively utilized in the commercial and biomedical sectors, posing heightened risks of potential cytotoxicity through various mechanisms. Nonetheless, regulatory framework governing gestational toxicity ZnO NPs corresponding intervention strategies remain largely obscure. In this study, using Drosophila model, we observed that exposure to led growth developmental anomalies a dose-dependent manner when compared with control (no NP exposure). Subsequent dietary administration Quercetin Astragaloside IV resulted effective mitigation induced by NPs. Moreover, latter also triggered activation ferroptosis pathway. The associated parameters were successfully ameliorated IV. Notably, treatment Ferrostatin-1 alleviated disorders arising from conclusion, our investigation demonstrated during gestation interfered development via pathway, underscoring significance supplementation for protection against toxicity.

Language: Английский

Ferroptosis inhibitors: past, present and future DOI Creative Commons
Lei Zhang, Yi Luo, Yang Xiang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed mechanisms its formation continue to explore effective inhibitors in disease. Recent studies shown correlation between pathological neurodegenerative diseases, as well diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for treatment ferroptosis-mediated diseases. This article specifically describes metabolic pathways summarizes reported action natural synthetic small molecule their efficacy The paper also treatments such gene therapy, nanotechnology, summarises challenges encountered clinical translation inhibitors. Finally, relationship other modes discussed, hopefully paving way future drug design discovery.

Language: Английский

Citations

20
Fine particulate matter (PM2.5) induces testosterone disruption by triggering ferroptosis through SIRT1/HIF-1α signaling pathway in male mice DOI
Shaokai Zheng, Jinchen Jiang,

Zhenhao Shu

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 221, P. 40 - 51

Published: May 15, 2024

Language: Английский

Citations

8
Unraveling the mechanism of quercetin alleviating BHPF-induced apoptosis in Epithelioma papulosum cyprini cells: SIRT3-mediated mitophagy DOI
Shasha Chen, Yidan Wang, Kai Chen

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 154, P. 109907 - 109907

Published: Sept. 13, 2024

Language: Английский

Citations

5
Study on the detoxification and toxic effects of clam Ruditapes philippinarum exposed to 2,6-ditert-butyl-4-methylphenol (BHT): oxidative stress, neurotoxicity, respiratory toxicity, and immunotoxicity DOI
Zeyuan Li,

Ruicheng Qi,

Qiaoqiao Wang

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: 268, P. 120839 - 120839

Published: Jan. 12, 2025

Language: Английский

Citations

0
Miquelianin inhibits IAV infection via the MAPK signaling pathway both in vitro and in vivo DOI Creative Commons
Li He,

Beilei Shen,

Yan Bi

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Influenza is an acute respiratory infectious disease primarily transmitted through airborne droplets. The prevalence and spread of influenza viruses have significant impacts on global economic development public health. Current prevention control strategies for virus infections mainly rely vaccines antiviral drugs. However, vaccine efficacy limited by the antigenic drift mutation characteristics viruses, while drug resistance increasingly prevalent. Therefore, there urgent need novel agents. Flavonoids, widely distributed in plants, possess various potent biological properties, including antioxidant, anti-inflammatory, antibacterial, anticancer activities, which contribute to management numerous diseases. This study aims investigate vitro vivo anti-influenza A activity quercetin, taxifolin, miquelianin, as well their underlying. In infection model (MDCK cells) mouse lethal Infuenza were used evaluate taxifolin miquelianin. Subsequently, we applied network pharmacology elucidate mechanism action validate findings Miquelianin effectively inhibits replication H1N1-UI182 both provides protection against mice. Compared virus-infected controls, miquelianin reduces lung injury. Furthermore, inhibiting MAPK signaling pathway, prevents overproduction cytokines, such IL-6 IL-1β, induced viral infection, thereby alleviating inflammatory responses. a monomer extracted from traditional Chinese medicine, exhibiting inhibitory effects injury mitigation.

Language: Английский

Citations

0
Dynamics of Inflammatory and Pathological Changes Induced by Single Exposure of Particulate Matter (PM2.5) in Mice: Potential Implications in COPD DOI

Jitender Chandel,

Amarjit S. Naura

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(4), P. 3463 - 3475

Published: July 20, 2024

Language: Английский

Citations

3
Use quercetin for pulmonary fibrosis: a preclinical systematic review and meta-analysis DOI
Xuanyu Wu, Xiang Xiao,

Yuchen Su

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Research advances in polyphenols from Chinese herbal medicine for the prevention and treatment of chronic obstructive pulmonary disease: a review DOI
Yang Zhang, Lijuan Wang,

Jinyi Zeng

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
cGAS deficiency mitigated PM2.5-induced lung injury by inhibiting ferroptosis DOI Creative Commons

Huasong Liu,

Juan Wang, Xiong Juan

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 288, P. 117321 - 117321

Published: Nov. 18, 2024

Language: Английский

Citations

0
Quercetin and Astragaloside IV Mitigate the Developmental Abnormalities Induced by Gestational Exposure to Zinc Oxide Nanoparticles DOI Creative Commons
Linong Ji,

Qiuru Huang,

Yujuan Qi

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(48), P. 47802 - 47810

Published: Nov. 19, 2024

Zinc oxide (ZnO) nanoparticles (NPs) are extensively utilized in the commercial and biomedical sectors, posing heightened risks of potential cytotoxicity through various mechanisms. Nonetheless, regulatory framework governing gestational toxicity ZnO NPs corresponding intervention strategies remain largely obscure. In this study, using Drosophila model, we observed that exposure to led growth developmental anomalies a dose-dependent manner when compared with control (no NP exposure). Subsequent dietary administration Quercetin Astragaloside IV resulted effective mitigation induced by NPs. Moreover, latter also triggered activation ferroptosis pathway. The associated parameters were successfully ameliorated IV. Notably, treatment Ferrostatin-1 alleviated disorders arising from conclusion, our investigation demonstrated during gestation interfered development via pathway, underscoring significance supplementation for protection against toxicity.

Language: Английский

Citations

0