Diagnostic challenges of heart failure with preserved ejection fraction: focus on echocardiography

CARDIOVASCULAR THERAPY AND PREVENTION, Journal Year: 2023, Volume and Issue: 22(5), P. 3565 - 3565

Published: June 21, 2023

Aim . To assess the features of diagnosing heart failure with preserved ejection fraction (HFpEF) using echocardiographic markers and diastolic stress test (DST) according to a survey ultrasound functional diagnostics specialists in Russian Federation. Materials methods As part study, an anonymous 155 diagnostic from various regions was conducted. We proposed answer whether they routinely certain parameters necessary for HFpEF. The also indicated conduct DST have opportunity refer patient this study. Results A frequency analysis responses received carried out. In routine practice, 83,2% measure left ventricular (LV) by Simpson method, 76,1% — Teichholz method. addition, 80% responders analyses LV mass index, relative wall thickness, 60% tricuspid annular plane systolic excursion, 56,8% atrial volume 51.6% E/e´ ratio, 94,8% pulmonary artery pressure, global longitudinal strain 16,1%, 7,7% strain. Also, 9,7% on their own, while 41,3% patients. Conclusion low assessment rate some ultrasonic HFpEF mar­kers among Federation reduces detection It is develop algorithms based mainly clinical anam­nestic data available use doctors any specialty.

Language: Английский

---

Obesity induced hypertension: The main pathophysiological mechanisms

Arterial’naya Gipertenziya (Arterial Hypertension), Journal Year: 2021, Volume and Issue: 27(3), P. 260 - 268

Published: Aug. 4, 2021

In most countries worldwide, hypertension (HTN) occupies a leading position in the structure of modifiable risk factors for cardiovascular diseases and their complications. One main reasons this trend is increasing prevalence obesity, which becoming an important factor high blood pressure (BP). The results numerous epidemiological studies showed association between obesity (assessed by body mass index (BMI)) BP levels, as well prognostic role BMI relation to development HTN. However, there currently no consensus on criterion that accurately predicts HTN associated Data from prospective observational greater value indirect direct indicators abdominal ectopic visceral adipose tissue.These facts stimulated research aimed at revealing pathophysiological mechanisms patients with overweight are reviewed article.

Language: Английский

---

Russian Medical Society for Arterial Hypertension Expert Consensus: Hypertension and COVID-19

Systemic Hypertension, Journal Year: 2020, Volume and Issue: 17(3), P. 35 - 41

Published: Oct. 28, 2020

The novel coronavirus infection (COVID-19) caused by the b-coronavirus SARS-CoV-2, and leads to acute respiratory distress-syndrome, has affected more than nineteen million people worldwide, resulting in 0.7 deaths as of August 2020. fact that virus uses angiotensin-converting enzyme 2 a receptor for entering target cell, high prevalence hypertension other cardiovascular diseases among patients with COVID-19, have serious discussions on management such patients. This consensus experts from Russian Medical Society Arterial Hypertension analyzed existing data relationship between COVID-19 hypertension, pathophysiological aspects penetration into cells use renin-angiotensin-aldosterone system inhibitors COVID-19.

Language: Английский

---

Obesity in the 21st Century. Prevalence, Phenotypes, Course Variants and Consequences

Bulletin of Science and Practice, Journal Year: 2024, Volume and Issue: 10(4), P. 268 - 303

Published: April 15, 2024

The review article examines the issues of obesity regarding its prevalence, phenotypes, course and consequences. anatomical, physiological functional features adipose tissue are discussed. “Discussion” section presents authors’ own clinical observations on therapeutic surgical in treatment obesity. Currently, is divided into white, brown beige. White can turn each other through beige stage. volume activity require greater expenditure metabolism oxygen molecules more pronounced women. components extracellular matrix collagen types I, III, V, VI. structure varies depending location, size fat, age, gender, state kidneys, thyroid gland, nature food, energy sleep patterns. With intense work cold exposure, hormone irisin formed skeletal muscles, which promotes transformation white or beige, helps reduce body weight obesity, has a beneficial effect type 2 diabetes mellitus associated diseases. Traditionally, obese individuals metabolically healthy unhealthy based degree metabolic disorders. In visceral lipolysis occurs with high intensity, supports development inflammation. decreased expression adiponectin accelerates atherosclerotic cardiovascular As increases, acquires an inflammatory phenotype, manifested by increased cytokines (interleukin-6, interleukin-1, interleukin-17, tumor necrosis factor-alpha), hyperactivation renin-angiotensin-aldosterone system, as well excessive cell infiltration immune system (leukocytes, neutrophils, T-lymphocytes, monocytes, macrophages). During inflammation tissue, (M1) atherogenic (M4) phenotypes macrophages dominate. morbid number reach up to 50% all cells.

Language: Английский

---

Obesity. Reasons, features and prospects

Obesity and metabolism, Journal Year: 2024, Volume and Issue: 21(2), P. 174 - 187

Published: June 17, 2024

Rapid changes in the morphological characteristics of population, which began middle last century, are due to habitat. The “obesogenic” environment that is formed urbanized spaces contributes physical inactivity and a hypercaloric diet, processes globalization contribute obesity population all countries world. From epidemic declared by WHO 1988, humanity has moved an pandemic. presented review analyzes global Russian trends development obesity. Data on prevalence latent diagnostic criteria for this condition presented. An analysis data dynamics BMI world Federation was carried out. Various options topography fat deposition their relationship with comorbid diseases considered. structure subcutaneous depot abdominal area influence outer (superficial adipose tissue, SSAT) deep (deep DSAT) layers fatty tissue risks developing discussed. results assessing value T/A substitution FTO gene (rs9939609) predicting proportion mass adults

Language: Английский

---