Multifunctional metal–organic frameworks as promising nanomaterials for antimicrobial strategies DOI Creative Commons
Qianjin Li, Fei Xing, Wenting Wu

et al.

Burns & Trauma, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Bacterial infections pose a serious threat to human health. While antibiotics have been effective in treating bacterial infectious diseases, antibiotic resistance significantly reduces their effectiveness. Therefore, it is crucial develop new and antimicrobial strategies. Metal–organic frameworks (MOFs) become ideal nanomaterials for various applications due crystalline porous structure, tunable size, good mechanical stability, large surface area, chemical stability. Importantly, the performance of MOFs can be adjusted by changing synthesis steps conditions. Pure release metal ions modulate cellular behaviors kill microorganisms. Additionally, act as carriers delivering agents desired manner. Furthermore, certain types combined with traditional photothermal or other physical stimuli achieve broad-spectrum activity. Recently an increasing number researchers conducted many studies on applying diseases caused infections. Based this, we perform this study report current status MOFs-based strategy. In addition, also discussed some challenges that currently face biomedical applications, such biocompatibility controlled capabilities. Although these limit widespread use, believe further research development, higher targeting capabilities provide diversified treatment strategies

Language: Английский

Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy DOI

Chaonan He,

Peipei Feng, Mingming Hao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 27, 2024

Abstract Antibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for treatment under the stimulation of light/ultrasound, which have characteristics broad‐spectrum properties, low drug‐resistance, effective targeting infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers sensitizers. They enhance stability permeability sensitizers, improve strengthen photodynamic/sonodynamic properties (modification absorption efficiency light/ultrasonic response stress by modulation nanoparticle shape, size, structure). Also, they modifiability (controlling release rate time sensitizer needed optimize therapeutic effect), programmability multifunctionality (flexible application nanotechnology designing with multiple functions, such drug delivery, targeted therapy, monitoring), expand possibilities combination therapies (the can be loaded other agents, enabling therapies). expected further promote development achieve improved effects. This review summarizes progress nanomaterials recent years based on current strategies provide a theoretical reference aPDT/aSDT.

Language: Английский

Citations

65

Chlorella‐Loaded Antibacterial Microneedles for Microacupuncture Oxygen Therapy of Diabetic Bacterial Infected Wounds DOI

Shuna Gao,

Yu Rao, Xiaowei Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)

Published: Feb. 2, 2024

Abstract Hypoxia and infection are urgent clinical problems in chronic diabetic wounds. Herein, living Chlorella ‐loaded poly(ionic liquid)‐based microneedles (PILMN‐Chl) constructed for microacupuncture oxygen antibacterial therapy against methicillin‐resistant Staphylococcus aureus (MRSA)‐infected The PILMN‐Chl can stably continuously produce more than 30 h due to the photosynthesis of loaded self‐supported . By combining barrier penetration capabilities microneedles, continuous sufficient supply , sterilization activities PIL, accelerate wounds vivo by topical targeted hypoxia relief deep parts Thus, self‐oxygen produced modality may provide a promising facile therapeutic strategy treating chronic, hypoxic, infected

Language: Английский

Citations

48

Metal-organic framework-based dressings: Application and opportunities in wound healing DOI

Qianying Huang,

Ying Chen,

Min Ye

et al.

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 40, P. 102235 - 102235

Published: Aug. 20, 2024

Language: Английский

Citations

45

MOFs and MOF‐Based Composites as Next‐Generation Materials for Wound Healing and Dressings DOI Creative Commons
Ashkan Bigham,

Negar Islami,

Arezoo Khosravi

et al.

Small, Journal Year: 2024, Volume and Issue: 20(30)

Published: March 7, 2024

Abstract In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds antimicrobial resistance. Metal–organic frameworks (MOFs) represent a promising class of next‐generation dressings. Their high surface area, pore structures, stimuli‐responsiveness, antibacterial properties, biocompatibility, potential combination therapies make them suitable complex care challenges. MOF‐based composites promote cell proliferation, angiogenesis, matrix synthesis, acting as carriers bioactive molecules promoting tissue regeneration. They also have stimuli‐responsivity, enabling photothermal skin cancer infections. Herein, critical analysis the current state research on MOFs dressings is provided, offering valuable insights into applications, challenges, future directions this field. This literature review targeted multifunctionality nature wound‐disease therapy from different aspects discussed most advancements made context, reader will find how contributed field yield more effective, functional, they lead next generation biomaterials

Language: Английский

Citations

40

Metal Nanoparticles: Advanced and Promising Technology in Diabetic Wound Therapy DOI Creative Commons
Qinzhou Zheng,

Cuimin Chen,

Yong Liu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 965 - 992

Published: Jan. 1, 2024

Abstract: Diabetic wounds pose a significant challenge to public health, primarily due insufficient blood vessel supply, bacterial infection, excessive oxidative stress, and impaired antioxidant defenses. The aforementioned condition not only places physical burden on patients' prognosis, but also amplifies the economic strain medical system in treating diabetic wounds. Currently, effectiveness of available treatments for is limited. However, there hope potential metal nanoparticles (MNPs) address these issues. MNPs exhibit excellent anti-inflammatory, antioxidant, antibacterial pro-angiogenic properties, making them promising solution In addition, stimulate expression proteins that promote wound healing serve as drug delivery systems small-molecule drugs. By combining with other biomaterials such hydrogels chitosan, novel dressings can be developed revolutionize treatment present article provides comprehensive overview research progress utilization Building upon this foundation, we summarize underlying mechanisms involved discuss application delivery. Furthermore, provide an extensive analysis discussion clinical implementation dressings, while highlighting future prospects utilizing management. conclusion, represent strategy healing. Future directions include biological nanomaterials synthesize new or physicochemical properties Synthetic contain play role all stages healing, stable physiological environment wound-healing process. Keywords: nanoparticles, wound, delivery, activity

Language: Английский

Citations

33

Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing DOI Creative Commons

Yuheng Liao,

Zhenhe Zhang,

Yanzhi Zhao

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 44, P. 131 - 151

Published: Oct. 15, 2024

Language: Английский

Citations

27

Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment DOI Creative Commons

Chaoxiong Wu,

Qingyu Yu,

Chenlu Huang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180

Published: Aug. 23, 2024

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.

Language: Английский

Citations

25

Direct 3D printing of triple-responsive nanocomposite hydrogel microneedles for controllable drug delivery DOI

Xinmeng Zhou,

Huan Liu,

Zilian Yu

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 670, P. 1 - 11

Published: May 9, 2024

Language: Английский

Citations

24

Nanozyme‐Incorporated Microneedles for the Treatment of Chronic Wounds DOI
Zhiyuan Hu,

Shan Jie,

Yuyu Cui

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: May 25, 2024

Acute wounds are converted to chronic due advanced age and diabetic complications. Nanozymes catalyze ROS production kill bacteria without causing drug resistance, while microneedles (MNs) can break through the skin barrier deliver drugs effectively. be intergrateded into MNs delivery systems improve painless delivery. It also reduce effective dose of sterilization increasing efficiency effectively killing wounded preventing resistance. This paper describes various types metal nanozymes from previous studies compares their mutual enhancement with nanozymes. The pooled results show that MNs, material innovation, able both penetrate scab exert additional anti-inflammatory bactericidal effects. catalytic effect some accelerate lysis or create a cascade reaction against inflammation infection. However, issue increased toxicity associated penetration clinical translation remains challenge. study reviews latest published corresponding challenges use combined for treatment wounds, providing further information future research.

Language: Английский

Citations

22

Photo-responsive polydopamine nanoenzyme microneedles with oxidative stress regulation ability for atopic dermatitis treatment DOI
Yuanyuan Zhang, Xiao‐Xuan Zhang,

Xiangyi Wu

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102241 - 102241

Published: March 28, 2024

Language: Английский

Citations

19