Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101498 - 101498
Опубликована: Янв. 19, 2025
Antimicrobial
peptides
show
promise
in
enhancing
photothermal
therapy,
but
their
application
is
often
limited
by
the
challenge
of
constructing
a
delivery
system
that
balances
efficacy
and
safety.
Our
research
demonstrated
bactericidal
V2C
MXene-mediated
therapy
enhanced
concentration-dependent
relationship
with
introduction
coating
antimicrobial
peptide
ε-polylysine
(EPL).
EPL
exhibited
dual
role
bacterial
binding
disrupting
membranes,
thereby
increasing
heat
transfer
efficiency
reducing
resistance
to
ablation.
The
core
strategy
this
study
was
exploit
combined
membranolytic-photothermal
effect
extensively
applying
while
regulating
nanosheets
usage
prevent
overheating.
This
approach
aims
achieve
potent
through
below
60
°C.
Consequently,
we
developed
dissolving
microneedles
incorporated
nanosheets,
where
served
as
agent
primary
matrix,
its
loading
capacity
minimizing
need
for
inactive
excipients.
Notably,
microneedle
achieved
99.9
%
reduction
abundance
methicillin-resistant
Staphylococcus
aureus
on
infected
skin
after
single
resulted
92-fold
load
compared
group
treated
commercial
Bactroban
ointment,
no
apparent
toxicity
mice.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(10), С. 12217 - 12231
Опубликована: Март 4, 2024
Psoriasis,
a
prevalent
chronic
inflammatory
skin
ailment
affecting
approximately
2–3%
of
the
global
population,
is
characterized
by
persistent
symptoms.
Dexamethasone,
primary
corticosteroid
for
treating
psoriasis,
demonstrates
notable
efficacy;
however,
its
limited
permeation
results
in
documented
adverse
effects.
To
address
this,
presented
study
employed
novel
strategy
to
conjugate
gold
nanorod
and
dexamethasone
evaluate
their
potential
mitigating
psoriatic
inflammation
using
an
imiquimod-induced
mouse
model
human
cells.
Our
findings
revealed
enhanced
cutaneous
penetration
conjugates
compared
with
that
dexamethasone,
owing
superior
penetration.
Gold
demonstrated
optimal
pharmacological
impact
at
minimal
dosages
without
toxicity
during
extended
use.
further
enhance
effectiveness
conjugates,
808
nm
near-infrared
laser
irradiation,
which
reacts
gold,
was
additionally
applied
achieve
thermal
elevation
expedite
drug
Supplementary
irradiation
significantly
ameliorated
symptoms
following
deep
This
corresponded
restored
peroxisome
proliferator-activated
receptor-γ
levels
accelerated
release
from
complex.
These
highlight
through
dermal
layers,
thereby
aiding
psoriasis
treatment.
Moreover,
compatibility
photothermal
therapy
offers
prospects
therapeutic
interventions
across
various
disorders.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
MXenzymes,
a
promising
class
of
catalytic
therapeutic
material,
offer
great
potential
for
tumor
treatment,
but
they
encounter
significant
obstacles
due
to
suboptimal
efficiency
and
kinetics
in
the
microenvironment
(TME).
Herein,
this
study
draws
inspiration
from
electronic
structure
transition
metal
vanadium,
proposing
leverage
TME
specific-features
induce
structural
transformations
sheet-like
vanadium
carbide
MXenzymes
(TVMz).
These
trigger
cascading
reactions
that
amplify
oxidative
stress,
thereby
significantly
enhancing
multimodal
therapy.
Specifically,
engineered
HTVMz,
coated
with
hyaluronic
acid,
exhibits
good
stability
generates
thermal
effect
under
NIR-II
laser
irradiation.
The
effect,
combined
characteristics,
facilities
transformation
into
ultra-small
oxide
nanozymes
(VOx).
enlarged
surface
area
VOx
substantially
enhances
ROS
regeneration
amplifies
which
promotes
lysosomal
permeability
induces
endoplasmic
reticulum
stress.
high-valent
interacts
intracellular
glutathione,
disrupting
redox
homeostasis
intensifying
stress
further.
amplifications
accelerate
apoptosis,
ferroptosis,
suppress
HSP90
expression.
Consequently,
heightened
sensitivity
HTVMz
synergistically
cell
death
via
pathways.
This
presents
an
innovative
strategy
therapy
by
manipulating
structures,
advancing
field
Chemical Society Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Since
their
discovery
over
a
decade
ago,
MXenes
have
transformed
the
field
of
"materials
for
healthcare",
stimulating
growing
interest
in
healthcare-related
applications.
These
developments
also
driven
significant
advancements
MXenes'
synthesis.
This
review
systematically
examines
synthesis
and
applications
sensing
biomedical
fields,
underscoring
pivotal
role
addressing
critical
challenges
modern
healthcare.
We
describe
experimental
by
combining
appropriate
laboratory
modules
with
mechanistic
principles
underlying
each
step.
In
addition,
we
provide
extensive
details
on
parameters,
considerations,
essential
instructions
successful
Various
healthcare
including
sensing,
imaging,
synergistic
therapies,
regenerative
medicine,
wearable
devices
been
explored.
further
highlight
emerging
trends
MXenes,
viz.,
as
nanovehicles
drug
delivery,
vectors
gene
therapy,
tools
immune
profiling.
By
identifying
important
parameters
that
define
utility
applications,
this
outlines
strategies
to
regulate
profile,
thereby
serving
valuable
guide
design
application-specific
properties.
The
final
section
integrates
research
theoretical
studies
comprehensive
understanding
field.
It
technologies,
such
artificial
intelligence
(AI)
machine
learning
(ML),
accelerating
material
discovery,
structure-property
optimization,
automation.
Complemented
detailed
supplementary
information
synthesis,
stability,
biocompatibility,
environmental
impact,
insights,
offers
profound
knowledge
base
diverse
family
2D
materials.
Finally,
compared
potential
other
materials
underscore
existing
prioritize
interdisciplinary
collaboration.
synthesizing
key
from
its
current
(especially
2018
onward),
provides
cohesive
assessment
MXene
foundations
prospects
sector.
MXene-based
materials
have
attracted
significant
interest
due
to
their
distinct
physical
and
chemical
properties,
which
are
relevant
fields
such
as
energy
storage,
environmental
science,
biomedicine.
MXene
has
shown
potential
in
the
area
of
tissue
regenerative
medicine.
However,
research
on
its
applications
regeneration
is
still
early
stages,
with
a
notable
absence
comprehensive
reviews.
This
review
begins
detailed
description
intrinsic
properties
MXene,
followed
by
discussion
various
nanostructures
that
can
form,
spanning
from
0
3
dimensions.
The
focus
then
shifts
biomaterials
engineering,
particularly
immunomodulation,
wound
healing,
bone
regeneration,
nerve
regeneration.
MXene's
physicochemical
including
conductivity,
photothermal
characteristics,
antibacterial
facilitate
interactions
different
cell
types,
influencing
biological
processes.
These
highlight
modulating
cellular
functions
essential
for
Although
developing,
versatile
structural
attributes
suggest
role
advancing
Advanced Materials,
Год журнала:
2024,
Номер
36(45)
Опубликована: Сен. 3, 2024
Abstract
Addressing
the
inefficiency
of
current
therapeutic
approaches
for
hepatocellular
carcinoma
is
an
urgent
and
pressing
challenge.
PANoptosis,
a
form
inflammatory
programmed
cell
death,
presents
dependable
strategy
combating
cancer
by
engaging
multiple
death
pathways
(apoptosis,
pyroptosis,
necroptosis).
In
this
study,
ultrasmall
Bi
2
Sn
O
7
nanozyme
with
ultrasound‐magnified
multienzyme‐mimicking
properties
designed
engineered
as
PANoptosis
inducer
through
destroying
mitochondrial
function
tumor
cells
enhancing
intracellular
accumulation
toxic
reactive
oxygen
species,
finally
triggering
activation
process.
The
role
has
been
verified
expression
related
proteins,
including
cleaved
Caspase
3,
NLRP3,
N‐GSDMD,
1,
p‐MLKL,
RIPK3.
inclusion
external
ultrasonic
irradiation
significantly
augments
enzyodynamic
efficiency.
vitro
in
vivo
antineoplastic
efficacy,
along
inhibition
lung
metastasis,
validate
benefits
‐mediated
pathway.
This
study
not
only
elucidates
intricate
mechanisms
underlying
inducer,
but
also
offers
novel
perspective
treatment
carcinoma.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 9, 2024
Abstract
Lithium‐sulfur
(Li–S)
batteries
are
facing
a
multitude
of
challenges,
mainly
pertaining
to
the
sluggish
sulfur
redox
kinetics
and
rampant
lithium
dendrite
growth
on
cathode
anode
side,
respectively.
In
this
sense,
MXene
has
shown
conspicuous
advantages
in
serving
as
dual‐functional
promotor
for
Li–S
throughout
morphologic
engineering,
but
still
suffers
from
poor
electrocatalytic
activity
insufficient
lithophilic
sites.
Herein,
atomically
dispersed
Co
sites
seeded
onto
size
effect‐enabled
V
2
C
spheres
(Co‐VC),
leading
generation
unique
coordination
configurations
rich
active
Electrochemical
tests
combined
with
synchrotron
radiation
X‐ray
3D
nano‐computed
tomography
theoretical
calculations
unravel
that
Co‐VC
optimal
environments
simultaneously
boost
reaction
nucleation.
As
consequence,
modified
separator
can
sustain
stable
operation
over
700
cycles
negligible
capacity
decay
at
1.0
C,
delivers
an
areal
9.0
mAh
cm
−2
desired
cyclic
performance
high
loading
7.6
mg
lean
electrolyte
dosage
4.0
µL
S
−1
0.1
C.
The
work
opens
new
avenue
boosting
atomic‐scale
site
design
aid
2D
substrates
toward
pragmatic
batteries.
ACS Materials Letters,
Год журнала:
2024,
Номер
6(5), С. 1801 - 1810
Опубликована: Апрель 3, 2024
Functions
such
as
biocompatibility,
degradability,
therapeutics,
and
imaging
are
critical
for
use
of
microrobots
in
clinical
scenarios;
however,
incorporation
these
functions
into
a
single
microrobotic
entity
is
still
challenging.
Herein,
we
report
multifunctional
Ti3C2
MXene-based
magnetically
actuated
(MXBOTs),
which
prepared
by
sequentially
electrostatic
coating
nanosheets
Fe3O4
nanoparticles
on
the
surface
biodegradable
gelatin
methacryloyl
(GelMA)-based
helical
microstructures.
These
MXBOTs
can
move
along
predefined
paths
under
rotating
magnetic
field.
The
provides
with
an
advantageous
photothermal
effect
photoacoustic
(PA)
capability.
Additionally,
be
loaded
fluorescent
molecules,
enabling
fluorescence
imaging.
After
loading
chemotherapeutic
drug
DOX,
MXBOTs@DOX
were
able
to
accelerate
release
DOX
stimulation
temperature
acidic
pH.
This
work
presents
viable
approach
developing
functional
targeted
delivery
synergistic
chemo-photothermal
therapy.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Авг. 30, 2024
Hydrogen
sulfide
is
essential
in
numerous
physiological
and
pathological
processes
has
emerged
as
a
promising
cancer
imaging
signaling
molecule
potentially
versatile
therapeutic
agent.
However,
the
endogenous
levels
of
hydrogen
remain
insufficient
to
perform
its
biological
functions,
thus,
developing
novel
strategies
that
amplify
signals
at
lesion
sites
increasing
interest.
In
this
work,
nanoplatform
(SNP)
based
on
sulfide-responsive
self-immolative
poly(thiocarbamate)
with
localized
signal
amplification
capability
developed
encapsulate
fluorescent
probe
(e.g.,
hemicyanine
dye;
p-Cy)
or
an
anticancer
prodrug
doxorubicin;
p-DOX)
form
nanoprobe
(SNP
