Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 157746 - 157746
Опубликована: Ноя. 1, 2024
Язык: Английский
ACS Nano, Год журнала: 2024, Номер 18(27), С. 17852 - 17868
Опубликована: Июнь 28, 2024
The discovery of cuproptosis, a copper-dependent mechanism programmed cell death, has provided way for cancer treatment. However, cuproptosis inherent limitations, including potential cellular harm, the lack targeting, and insufficient efficacy as standalone Therefore, exogenously controlled combination treatments have emerged key strategies cuproptosis-based oncotherapy. In this study, Cu2–xSe@cMOF nanoplatform was constructed combined sonodynamic/cuproptosis/gas therapy. This platform enabled precise cotreatment, with external control allowing selective induction in cells. approach effectively prevented metastasis recurrence. Furthermore, antiprogrammed death protein ligand-1 antibody (aPD-L1), maximized advantages immune checkpoint Additionally, under ultrasound irradiation, H2Se gas generated from induced cytotoxicity Further, it reactive oxygen species, which hindered survival proliferation. study reports an externally system that combines carbonized metal–organic framework aPD-L1 to enhance precision reinforced therapy could be valuable effective therapeutic agent reduce mortality morbidity future.
Язык: Английский
Процитировано
64
Advanced Materials, Год журнала: 2024, Номер 36(26)
Опубликована: Март 29, 2024
Abstract Sonodynamic therapy (SDT) is applied to bladder cancer (BC) given its advantages of high depth tissue penetration and nontoxicity due the unique anatomical location near abdominal surface. However, low electron–hole separation efficiency wide bandgap sonosensitizers limit effectiveness SDT. This study aims develop a TiO 2 ‐Ru‐PEG Schottky heterojunction sonosensitizer with narrow for SDT in BC. Density functional theory (DFT) calculations experiments collectively demonstrate that reduced characteristic crystalline‐amorphous interface formed by deposition ruthenium (Ru) within shell layer . Thanks enhancement oxygen adsorption efficient pairs, promotes generation reactive species (ROS) under ultrasound (US) irradiation, resulting cell cycle arrest apoptosis tumor cells. The vivo results prove boosted subcutaneous orthotopic models while exhibiting good safety. adopts complex optimizing sonosensitizers, contributing progress improvement strategies presenting paradigm BC therapy.
Язык: Английский
Процитировано
31
ACS Nano, Год журнала: 2024, Номер 18(20), С. 13226 - 13240
Опубликована: Май 7, 2024
Oncogene activation and epigenome dysregulation drive tumor initiation progression, contributing to immune evasion compromising the clinical response immunotherapy. Epigenetic immunotherapy represents a promising paradigm in conquering cancer immunosuppression, whereas few relevant drug combination delivery strategies emerge clinic. This study presents well-designed triune nanomodulator, termed ROCA, which demonstrates robust capabilities epigenetic modulation microenvironment reprogramming for The nanomodulator is engineered from nanoscale framework with cascaded catalytic activity, self-assembles into nanoaggregate targeting polypeptide decoration that enables loading of immunogenic cell death (ICD)-inducing agent. releases active factors specifically triggered microenvironment, represses oncogene expression, initiates type 1 T helper (TH1) chemokine axis by reversing DNA hypermethylation. process, together ICD induction, fundamentally reprograms significantly enhances rejuvenation exhausted cytotoxic lymphocytes (CTLs, CD8+ cells), synergizes anti-PD-L1 checkpoint blockade results boosted antitumor response. Furthermore, this strategy establishes long-term memory effectively prevents orthotopic colon relapse. Therefore, holds promise as standalone agent or part therapy inhibitors preclinical models, broadening array combinatorial
Язык: Английский
Процитировано
17
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 28, 2025
Cancer treatment is currently one of the most critical healthcare issues globally. A well-designed drug delivery system can precisely target tumor tissues, improve efficacy, and reduce damage to normal tissues. Stimuli-responsive systems (SRDDSs) have shown promising application prospects. Intelligent nano responsive endogenous stimuli such as weak acidity, complex redox characteristics, hypoxia, active energy metabolism, well exogenous like high temperature, light, pressure, magnetic fields are increasingly being applied in chemotherapy, radiotherapy, photothermal therapy, photodynamic various other anticancer approaches. Metal–organic frameworks (MOFs) become candidate materials for constructing SRDDSs due their large surface area, tunable porosity structure, ease synthesis modification, good biocompatibility. This paper reviews MOF-based modes cancer therapy. It summarizes key aspects, including classification, synthesis, modifications, loading modes, stimuli-responsive mechanisms, roles different modalities. Furthermore, we address current challenges summarize potential applications artificial intelligence MOF synthesis. Finally, propose strategies enhance efficacy safety SRDDSs, ultimately aiming at facilitating clinical translation.
Язык: Английский
Процитировано
2
Small, Год журнала: 2024, Номер 20(44)
Опубликована: Июль 6, 2024
Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.
Язык: Английский
Процитировано
14
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 23, 2024
Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.
Язык: Английский
Процитировано
10
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 10, 2024
Over the past two decades, iron-based metal-organic frameworks (Fe-MOFs) have attracted significant research interest in biomedicine due to their low toxicity, tunable degradability, substantial drug loading capacity, versatile structures, and multimodal functionalities. Despite great potential, transition of Fe-MOFs-based composites from laboratory clinical products remains challenging. This review evaluates key properties that distinguish Fe-MOFs other MOFs highlights recent advances synthesis routes, surface engineering, shaping technologies. In particular, it focuses on applications biosensing, antimicrobial, anticancer therapies. addition, emphasizes need develop scalable, environmentally friendly, cost-effective production methods for additional meet specific requirements various biomedical applications. ability combine therapies, hurdles still remain, including a deeper understanding therapeutic mechanisms potential risks resistance overdose. Systematically addressing these challenges could significantly enhance prospects potentially facilitate integration into mainstream practice.
Язык: Английский
Процитировано
6
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(8), С. 5226 - 5236
Опубликована: Июнь 29, 2024
Metal peroxide nanomaterials as efficient hydrogen (H2O2) self-supplying agents have attracted the attention of researchers for antitumor treatment. However, relying solely on metal peroxides to provide H2O2 is undoubtedly insufficient achieve optimal effects. Herein, we construct novel hyaluronic acid (HA)-modified nanocomposites (MgO2/Pd@HA NCs) formed by decorating palladium nanoparticles (Pd NPs) onto surfaces a magnesium (MgO2) nanoflower highly effective nanoplatform tumor microenvironment (TME)-responsive induction ferroptosis in cells and photothermal therapy (PTT). MgO2/Pd@HA NC could be well endocytosed into with CD44 expression depending specific recognition HA CD44, then, can rapidly decomposed mild hyaluronidase overexpressed TME, plenty was released. Simultaneously, Pd NPs catalyze self-supplied generate abundant hydroxyl radicals (•OH) glutathione (GSH) disulfide owing its peroxidase oxidase mimic enzyme activities, while •OH also consume GSH disturb defense pathways leading accumulation lipid peroxidation resulting occurrence ferroptosis. Additionally, superior conversion performance near-infrared II used PTT, synergistically cooperating nanocomposite-induced inhibition. Consequently, successfully prepared TME-responsive NCs exhibited marked effect without obvious biotoxicity, contributing thoroughly explore promising treatment therapy.
Язык: Английский
Процитировано
5
Advanced Materials, Год журнала: 2024, Номер 36(52)
Опубликована: Ноя. 16, 2024
Radiofrequency ablation (RFA), a critical therapy for hepatocellular carcinoma (HCC), carries significant risk of recurrence and metastasis, particularly owing to mechanisms involving immune evasion antigen downregulation via epigenetic modifications. This study introduces "nano-epidrug" named MFMP. MFMP, which is composed hollow mesoporous manganese dioxide (MnO2) nanoparticles, FIDAS-5 as an MAT2A inhibitor, macrophage membrane, anti-PD-L1 (aPD-L1), targets HCC cells. By selectively binding these cells, MFMP initially reverses suppression PD-L1 inhibition. After endocytosis, disassembles in the tumor microenvironment, releasing Mn2+. prevents cGAS methylation, whereas Mn2+ aids STING pathway restoration. In addition, reduces m6A RNA modification, suppressing EGFR expression. These changes enhance antigenicity promote cytotoxic T cell recognition killing. Furthermore, mediates immunogenic death by synergizing with RFA through DNA demethylation, mRNA TBK1 protein phosphorylation, thereby inhibiting metastasis enhancing memory. Thus, potential adjunctive requiring clinical validation.
Язык: Английский
Процитировано
4
Bioactive Materials, Год журнала: 2025, Номер 47, С. 83 - 99
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
0