Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment

Nano-Micro Letters, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 24, 2025

Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.

Язык: Английский

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Sono‐Piezo Dynamic Therapy: Utilizing Piezoelectric Materials as Sonosensitizer for Sonodynamic Therapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Sonodynamic therapy (SDT) represents a promising approach for cancer treatment. Compared to photodynamic therapy, SDT offers increased penetration depth and higher precision. However, the practical application of is constrained by low water solubility, poor tumor specificity, metabolic susceptibility most sonosensitizers. Recent research has explored use piezoelectric materials as sonosensitizers in treatment inhibition bacterial growth. Upon ultrasound excitation, separation electron-hole (e--h+) pairs occurs within material. By improving crystal structure material or incorporating other nanoparticles prevent rapid recombination e--h+ pairs, accumulates charges conduction band valence band, achieving redox potential O2/·O2 -. This enables serve sonosensitizer, leading concept termed Sono-Piezo Dynamic Therapy (SPDT). review aims define SPDT, provide systematic overview historical development SDT, elucidate mechanisms which act Importantly, various will be discussed terms their feasibility, advantages, disadvantages sonosensitizers, offering new perspectives identifying

Язык: Английский

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Nanoplatforms Based on Covalent Organic Frameworks (COFs) for Biomedical Applications

Chemistry of Materials, Год журнала: 2023, Номер 35(20), С. 8353 - 8370

Опубликована: Окт. 12, 2023

Covalent organic frameworks (COFs) make up an emerging class of crystalline porous materials mainly composed light elements in the form dynamic covalent bonds. Owing to their two- or three-dimensional network structures and ideal properties, including low density, large specific surface area, high chemical stability, good biocompatibility, COFs have shown a wide range applications optoelectronic devices, energy conversion storage, adsorption separation, sensing, catalysis, biomedicine. This review provides overview recent advances functional COF-based nanoplatforms for biological diagnosis treatment, such as enzyme protein drug delivery, photodynamic/photothermal therapy, synergistic treatment. Challenges future directions developing biomedicine related are also discussed. We envisage that this will inspire scientists, chemists, biologists, clinical doctors working fields work closely move field toward trials human healthcare.

Язык: Английский

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Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy

Small, Год журнала: 2024, Номер 20(44)

Опубликована: Июль 6, 2024

Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.

Язык: Английский

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Tumor Microenvironment‐Activatable Metal‐Phenolic Nanoformulations for Ultrasound‐Boosted Ferroptosis through Triple Regulatory Pathways

Advanced Functional Materials, Год журнала: 2024, Номер 34(44)

Опубликована: Июль 16, 2024

Abstract Despite its effectiveness in exterminating tumor cells, ferroptosis is seriously hampered by the high expression of antioxidant glutathione (GSH) and inadequacy endogenous H 2 O tumors. Herein, metal‐phenolic nanoformulations (FNCP NFs) composed sonosensitizer Chlorin e6 (Ce6), phenolic GSH consumer naphthazarin, Fe 3+ , followed modification PEG2000, are strategically designed fabricated for ultrasound‐boosted cells through triple regulatory pathways. The carrier‐free FNCP NFs can rapidly dissociate under microenvironment response with assistance ultrasound, releasing 2+ Ce6, naphthazarin. Ce6 capable producing singlet oxygen ( 1 ) hydroxyl radicals · OH) ultrasound‐activated sonodynamic therapy Fenton reaction‐mediated chemodynamic (CDT), respectively, which not only induce apoptotic cell death but also lead to effective accumulation lipid peroxidation (LPO), resulting ferroptosis. Meanwhile, released naphthazarin self‐cycling valence alternations /Fe promote significant decrease intracellular contents, further inducing inactivation peroxidase 4 (GPX4) up‐regulation LPO levels, eventually realizing synergistically enhanced This facile feasible design versatile offers a new strategy effectively improving efficiency multimodal cancer therapies.

Язык: Английский

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Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Язык: Английский

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Catalytic Biomaterials

Accounts of Materials Research, Год журнала: 2024, Номер 5(3), С. 271 - 285

Опубликована: Фев. 16, 2024

ConspectusCatalytic biomaterials, an emerging frontier in biomaterials research, offer tremendous potential to circumvent the limitations of traditional treatment approaches, such as low specificity and adverse effects. By harnessing intrinsic physicochemical properties materials, catalytic especially nanoscale (termed nanomedicine), can directly engage with a range biogenic substrates initiate various chemical or biochemical reactions vivo. Chemically designed nanozymes emulate endogenous enzymes regulating intracellular redox homeostasis, offering distinct advantages over their natural counterparts, design flexibility, adjustable functionalities, robust stability harsh conditions, cost-effective production. The extensively investigated mimicked by include peroxidases, oxidases, superoxide dismutases, catalase, glutathione peroxidase. To improve enzyme-mimicking activities properties, composition, size, morphology, exposed crystal facets, surface chemistry, are finely tuned for reactive oxygen species (ROS)-producing pro-oxidative ROS-eliminating antioxidative applications. As interdisciplinary research catalysis biomedicine deepens, cutting-edge concepts catalysis, including single-atom photocatalysis, electrocatalysis, piezoelectric thermoelectric have gradually merged biomaterials. resultant be activated spatiotemporally light, ultrasound, magnetic fields, heat, etc., beyond scope aforementioned endogenously responsive nanozymes. Given semiconductor nature these externally defect engineering heterojunction strategies utilized enhance separation suppress recombination electron–hole pairs modulating bandgap structures. Consequently, efficacy rationally engineered generating scavenging ROS profoundly improved. Apart from ROS-centered applications, content has also been extended transformation substrates, depletion, glucose/lactate consumption, gas production inorganic nanocatalysts. Collectively, which purposefully influence cellular homeostasis regulate cell signaling pathways, assumed play pivotal role addressing spectrum pathophysiological disorders associated oxidative stress dysfunctions, cancer, inflammation, immunomodulation, neurodegeneration, cardiovascular diseases. connections among nanomedicine, nanozymes, we present our insights here clarify distinctions. Catalytic broader scope, spanning nanoscale, microscale, macroscale that possess specific activities. involved encompass both enzyme-mimetic well endogenously/exogenously initiated nanomedicine emphasizes integration nanotechnology therapeutic Nanozymes specifically focus on nanomaterials. Thus, utilize term "catalytic biomaterials" describe this fast-evolving field anticipate will motivate deeper between materials science, medicine.In Account, provide concise introduction fundamental understanding categorizing them into three groups based action mechanisms. Then, highlight group's work fabrication diverse biomedical cancer therapy, antibacterial, anti-inflammation, tissue engineering, regenerative medicine Our primary is deliberate tailor-made application sophisticated scenarios. biological effects arising elucidated. Furthermore, perspectives clinical translation discussed. We envision rapid development could spur evolution highly effective therapeutic/regenerative approaches minimal toxicity wide medical conditions.

Язык: Английский

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Self-assembled nanodrug based on ferroptosis inducer and sonosensitizer for enhanced sonodynamic-triggered multimodal synergistic therapy of prostate cancer

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2025, Номер 208, С. 114656 - 114656

Опубликована: Фев. 3, 2025

Язык: Английский

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Single-atom–doped piezocatalyst induces copper-free cuproptosis in tumor therapy

Science Advances, Год журнала: 2025, Номер 11(7)

Опубликована: Фев. 14, 2025

Cuproptosis, a distinct cell death pathway, has been integrated into nanomedicine for disease theranostics. However, current nanosystems inducing cuproptosis rely on exogenous toxic copper ions, limiting the scope of biomaterials. Developing nanoplatforms that induce without holds substantial promise. Here, we engineered two-dimensional iron (Fe) single-atom–doped molybdenum disulfide (MoS 2 ) piezocatalyst (Fe-MoS tumor therapy. Incorporating single Fe atoms enhances MoS piezoelectric polarization via charge redistribution and modulates Mo oxidation states, enabling multifaceted enzymatic activities, including peroxidase-, glutathione oxidase–, oxidase-, catalase-like activities. Upon ultrasound stimulation, Fe-MoS nanocatalyst generates reactive oxygen species depletes synergistic piezocatalytic enzyocatalytic effects, disrupting ion homeostasis cuproptosis, concurrently triggering ferroptosis ferritinophagy, which collectively suppression. This study represents first paradigm to introduce copper-free initiating substantially advancing applications in

Язык: Английский

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Ruthenium Single‐Atom Nanozyme Driven Sonosensitizer with Oxygen Vacancies Enhances Electron–Hole Separation Efficacy and Remodels Tumor Microenvironment for Sonodynamic‐Amplified Ferroptosis

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Abstract Sonodynamic therapy (SDT) has emerged as a promising noninvasive approach for tumor therapy. However, the effectiveness of traditional inorganic semiconductor sonosensitizers is hindered by rapid electron (e − ) and hole (h + recombination under ultrasonic (US) stimulation, well hypoxic reductive conditions microenvironment (TME), which limit generation reactive oxygen species (ROS). Herein, ruthenium (Ru) single‐atom nanozyme‐driven superimposition‐enhanced titanium dioxide‐based sonosensitizer (Ru/TiO 2‐x SAE) presented that features sufficient vacancies high e /h separation efficiency. Through synchrotron radiation‐based X‐ray absorption spectroscopy extended fine structure analysis it confirmed in TiO nanoparticles promote immobilization single‐atomic Ru, forming Ru‐O₄ active sites. Density functional theory calculations demonstrate alter electronic nanosensitizer, enhanced separation, increasing adsorption, accelerating reaction kinetics US ultimately improving ROS production. Moreover, Ru/TiO SAE boosts sonodynamic efficacy mitigating TME. This attributed to its catalase‐ glutathione peroxidase 4‐like activities, facilitate trigger lipid peroxidation‐mediated ferroptosis. These findings highlight innovative role Ru optimizing SDT‐induced ferroptosis, demonstrating potential advancing cancer

Язык: Английский

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