Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(26)
Опубликована: Авг. 4, 2023
Abstract
The
application
of
nanomaterials
in
healthcare
has
emerged
as
a
promising
strategy
due
to
their
unique
structural
diversity,
surface
properties,
and
compositional
diversity.
In
particular,
have
found
significant
role
improving
drug
delivery
inhibiting
the
growth
metastasis
tumor
cells.
Moreover,
recent
studies
highlighted
potential
modulating
microenvironment
(TME)
enhancing
activity
immune
cells
improve
therapy
efficacy.
Various
types
are
currently
utilized
carriers,
immunosuppressants,
activators,
immunoassay
reagents,
more
for
immunotherapy.
Necessarily,
used
immunotherapy
can
be
grouped
into
two
categories:
organic
inorganic
nanomaterials.
Though
both
shown
ability
achieve
purpose
immunotherapy,
composition
properties
result
differences
mechanisms
modes
action.
Organic
further
divided
polymers,
cell
membranes,
nanoemulsion‐modified,
hydrogel
forms.
At
same
time,
broadly
classified
nonmetallic
metallic
current
work
aims
explore
action
these
different
prospects
promoting
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
Abstract
For
tumor
treatment,
the
ultimate
goal
in
therapy
is
to
eliminate
primary
tumor,
manage
potential
metastases,
and
trigger
an
antitumor
immune
response,
resulting
complete
clearance
of
all
malignant
cells.
Tumor
microenvironment
(TME)
refers
local
biological
environment
solid
tumors
has
increasingly
become
attractive
target
for
cancer
therapy.
Neutrophils
within
TME
gastric
(GC)
spontaneously
undergo
ferroptosis,
this
process
releases
oxidized
lipids
that
limit
T
cell
activity.
Enhanced
photodynamic
(PDT)
mediated
by
di‐iodinated
IR780
(Icy7)
significantly
increases
production
reactive
oxygen
species
(ROS).
Meanwhile,
neutrophil
ferroptosis
can
be
triggered
increased
ROS
generation
TME.
In
study,
a
liposome
encapsulating
both
inhibitor
Liproxstatin‐1
modified
photosensitizer
Icy7,
denoted
LLI,
inhibits
growth
GC.
LLI
internalizes
into
MFC
cells
generate
causing
immunogenic
death
(ICD).
Simultaneously,
liposome‐deliver
effectively
neutrophils.
LLI‐based
PDT
neutrophil‐targeting
immunotherapy
synergistically
boost
anti‐PD‐1
treatment
elicit
potent
systemic
response
with
abscopal
effects.
conclusion,
holds
great
GC
immunotherapy.
Pharmaceutics,
Год журнала:
2021,
Номер
13(8), С. 1151 - 1151
Опубликована: Июль 27, 2021
The
encapsulation
of
therapeutic
agents
into
nano-based
drug
delivery
system
for
cancer
treatment
has
received
considerable
attention
in
recent
years.
Advancements
nanotechnology
provide
an
opportunity
efficient
anticancer
drugs.
unique
properties
nanoparticles
not
only
allow
cancer-specific
by
inherent
passive
targeting
phenomena
and
adopting
active
strategies,
but
also
improve
the
pharmacokinetics
bioavailability
loaded
drugs,
leading
to
enhanced
efficacy
safety
compared
conventional
modalities.
Small
molecule
drugs
are
most
widely
used
at
present,
while
biological
macromolecules,
such
as
antibodies,
peptides
genes,
have
gained
increasing
attention.
Therefore,
this
review
focuses
on
achievements
novel
nano-encapsulation
targeted
delivery.
A
comprehensive
introduction
intelligent
strategies
based
various
nanocarriers
encapsulate
small
chemotherapeutic
macromolecule
will
be
highlighted.
Theranostics,
Год журнала:
2022,
Номер
12(10), С. 4629 - 4655
Опубликована: Янв. 1, 2022
Photodynamic
therapy
(PDT)
is
a
promising
method
of
tumor
ablation
and
function-preserving
oncological
intervention,
which
minimally
invasive,
repeatable,
has
excellent
function
cosmetic
effect,
with
no
cumulative
toxicity.More
importantly,
PDT
can
induce
immunogenic
cell
death
local
inflammation,
thus
stimulating
the
body's
immune
response.However,
weak
immunity
induced
by
alone
insufficient
to
trigger
systemic
response
towards
cancer
cells.To
overcome
this
obstacle,
multiple
strategies
have
been
investigated,
including
microenvironment
remodeling,
vaccines,
subcellular-targeted
PDT,
synergistic
therapies.This
review
summarizes
latest
progress
in
development
improve
PDT-induced
effect
for
enhanced
treatment.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(50)
Опубликована: Окт. 18, 2022
The
performances
of
second
near-infrared
(NIR-II)
organic
phototheranostic
agents
(OPTAs)
depend
on
both
molecular
structure
and
packing
when
used
as
nanoparticles
(NPs).
Herein,
we
proposed
a
facile
structural
isomerization-induced
3D
spatial
donor
(D)-acceptor
(A)
interlocked
network
for
achieving
NIR-II
OPTAs.
Two
isomers,
4MNVDPP
6MNVDPP
were
synthesized
formulated
into
NPs.
6MNVDPP,
which
has
larger
electrostatic
potential
difference,
exhibits
compact
D-A
in
the
crystal
form,
while
forms
2D
D-D
type
J-aggregates.
Thus,
NPs
show
red-shifted
NIR
absorption
molar
extinction
coefficient
than
Thanks
to
typical
emission,
superior
photothermal-stability,
high
photothermal
conversion
efficiency
(89
%)
reactive
oxygen
species
production
capacity,
exhibit
outstanding
tiny
capillary
vasculature/tumor
imaging
ability
synergistic
photothermal/photodynamic
anti-cancer
effect
vivo.
Bioactive Materials,
Год журнала:
2022,
Номер
21, С. 1 - 19
Опубликована: Авг. 10, 2022
Although
nano-immunotherapy
has
advanced
dramatically
in
recent
times,
there
remain
two
significant
hurdles
related
to
immune
systems
cancer
treatment,
such
as
(namely)
inevitable
elimination
of
nanoplatforms
and
severely
immunosuppressive
microenvironment
with
low
immunogenicity,
hampering
the
performance
nanomedicines.
To
address
these
issues,
several
immune-regulating
camouflaged
nanocomposites
have
emerged
prevailing
strategies
due
their
unique
characteristics
specific
functionalities.
In
this
review,
we
emphasize
composition,
performances,
mechanisms
various
nanoplatforms,
including
polymer-coated,
cell
membrane-camouflaged,
exosome-based
evade
clearance
or
upregulate
function
against
tumor.
Further,
discuss
applications
directly
boosting
immunotherapy
some
immunogenic
death-inducing
immunotherapeutic
modalities,
chemotherapy,
photothermal
therapy,
reactive
oxygen
species-mediated
immunotherapies,
highlighting
current
progress
advancements.
Finally,
conclude
article
interesting
perspectives,
suggesting
future
tendencies
innovative
constructs
towards
translation
pipeline.
Abstract
Despite
the
clinical
potential,
photodynamic
therapy
(PDT)
relying
on
singlet
oxygen
(
1
O
2
)
generation
is
severely
limited
by
tumor
hypoxia
and
endosomal
entrapment.
Herein,
a
proton‐driven
transformable
‐nanotrap
(ANBDP
NPs)
with
escape
capability
presented
to
improve
hypoxic
PDT.
In
acidic
environment,
protonated
ruptures
membranes
via
“proton‐sponge”
like
effect
undergoes
drastic
morphology‐and‐size
change
from
nanocubes
(≈94.1
nm
in
length)
nanospheres
(≈12.3
diameter).
Simultaneously,
anthracenyl
boron
dipyrromethene‐derived
photosensitizer
(ANBDP)
transforms
its
form
(ANBDPH)
switches
off
charge‐transfer
state
achieve
amplified
photogeneration
capability.
Upon
730
photoirradiation,
ANBDPH
prominently
produces
traps
generated‐
anthracene
group
endoperoxide
(ANOBDPH).
Benefitting
hypoxia‐tolerant
‐release
property
of
ANOBDPH
dark,
brings
about
sustained
therapeutic
without
further
continuous
irradiation,
thereby
achieving
remarkable
antitumor
performance.
