Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(23)
Опубликована: Апрель 5, 2024
Abstract
Reactive
oxygen
species
(ROS)
have
become
an
effective
tool
for
tumor
treatment.
The
combination
of
photodynamic
therapy
(PDT)
and
chemodynamic
(CDT)
takes
advantage
various
ROS
enhances
therapeutic
effects.
However,
the
activation
CDT
usually
occurs
before
PDT,
which
hinders
sustained
maintenance
hydroxyl
radicals
(⋅OH)
reduces
treatment
efficiency.
Herein,
we
present
a
light‐triggered
nano‐system
based
on
molecular
aggregation
regulation
converting
cancer
from
PDT/photothermal
(PTT)
to
long‐lasting
CDT.
ordered
J‐aggregation
properties
cyanine
moiety
while
simultaneously
suppressing
capabilities
copper‐porphyrin
moiety.
Upon
light
irradiation,
Cu‐PCy
JNPs
demonstrate
strong
photothermal
Meanwhile,
triggers
rapid
degradation
backbone,
leading
destruction
J‐aggregation.
As
result,
is
sequentially
activated,
generation
⋅OH
observed
up
48
hours,
causing
potent
cellular
oxidative
stress
apoptosis.
Due
their
excellent
accumulation,
exhibit
in
vivo
ablation
through
therapy.
This
work
provides
new
approach
effectively
prolonging
activity
ROS‐based
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(31)
Опубликована: Сен. 14, 2023
Abstract
Although
CeO
2
nanomaterials
have
been
widely
explored
as
nanozymes
for
catalytic
therapy,
they
still
suffer
from
relatively
low
activities.
Herein,
the
catalyzing
generation
and
stabilization
of
oxygen
vacancies
on
nanorods
by
Pt
nanoclusters
via
H
gas
reduction
under
mild
temperature
(350
°C)
to
obtain
Pt/CeO
2−
x
,
which
can
serve
a
highly
efficient
nanozyme
cancer
is
reported.
The
deposited
atomic
layer
deposition
technique
not
only
catalyst
generate
through
hydrogen
spillover
effect,
but
also
stabilize
generated
vacancies.
Meanwhile,
provide
anchoring
sites
forming
strong
metal‐support
interactions
thus
preventing
their
agglomerations.
Importantly,
reduced
at
350
°C
(Pt/CeO
‐350R)
exhibits
excellent
enzyme‐mimicking
activity
reactive
species
(e.g.,
·OH)
compared
other
control
samples,
including
temperatures,
achieving
performance
tumor‐specific
therapy
efficiently
eliminate
cells
in
vitro
ablate
tumors
vivo.
‐350R
originates
good
activities
vacancy‐rich
nanoclusters.
Advanced Materials,
Год журнала:
2023,
Номер
36(9)
Опубликована: Ноя. 7, 2023
Sono-photodynamic
therapy
is
hindered
by
the
limited
tissue
penetration
depth
of
external
light
source
and
quick
recombination
electron-hole
owing
to
random
movement
charge
carriers.
In
this
study,
orthorhombic
ZnSnO
Advanced Materials,
Год журнала:
2024,
Номер
36(37)
Опубликована: Фев. 9, 2024
Abstract
The
diagnosis
and
treatment
of
solid
tumors
have
undergone
significant
advancements
marked
by
a
trend
toward
increased
specificity
integration
imaging
therapeutic
functions.
multifaceted
nature
inorganic
oxide
nanomaterials
(IONs),
which
boast
optical,
magnetic,
ultrasonic,
biochemical
modulatory
properties,
makes
them
ideal
building
blocks
for
developing
multifunctional
nanoplatforms.
A
promising
class
materials
that
emerged
in
this
context
are
peptide‐functionalized
(PFIONs),
demonstrated
excellent
performance
therapy,
making
potential
candidates
advancing
tumor
treatment.
Owing
to
the
functionalities
peptides
targeting,
penetration,
responsiveness,
well‐designed
PFIONs
can
specifically
accumulate
release
or
agents
at
sites,
enabling
precise
effective
This
review
provides
an
overview
recent
advances
use
tumors,
highlighting
superiority
as
well
synergistic
Moreover,
discusses
challenges
prospects
depth,
aiming
promote
intersection
interdisciplinary
facilitate
their
clinical
translation
development
personalized
diagnostic
systems
optimizing
material
systems.
Abstract
Nanoformulations
with
endogenous/exogenous
stimulus‐responsive
characteristics
show
great
potential
in
tumor
cell
elimination
minimal
adverse
effects
and
high
precision.
Herein,
an
intelligent
nanotheranostic
platform
(denoted
as
TPZ@Cu‐SnS
2‐x
/PLL)
for
microenvironment
(TME)
near‐infrared
light
(NIR)
activated
tumor‐specific
therapy
is
constructed.
Copper
(Cu)
doping
the
resulting
sulfur
vacancies
can
not
only
improve
response
range
of
visible
but
also
separation
efficiency
photogenerated
carriers
increase
carrier
density,
ideal
photothermal
photodynamic
performance.
Density
functional
theory
calculations
revealed
that
introduction
Cu
induce
electron
redistribution,
achieving
favorable
electrons.
After
entering
cells
through
endocytosis,
/PLL
nanocomposites
pH
responsivity
property
release
TPZ
selectively
within
acidic
TME,
released
2+
first
interact
local
glutathione
(GSH)
to
deplete
GSH
production
+
.
Subsequently,
‐mediated
Fenton‐like
reaction
decompose
hydrogen
peroxide
into
hydroxyl
radicals,
which
be
promoted
by
hyperthermia
derived
from
effect
apoptosis.
The
integration
photoacoustic/computed
tomography
imaging‐guided
NIR
phototherapy,
TPZ‐induced
chemotherapy,
GSH‐elimination/hyperthermia
enhanced
chemodynamic
results
synergistic
therapeutic
outcomes
without
obvious
systemic
toxicity
vivo.
Chemical Society Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
review
provides
a
comprehensive
summary
of
the
dysregulation
redox
metabolism
in
cancer
cells
and
advantages
latest
advances
nanomaterial-assisted
metabolic
regulation
therapy.
