Tailoring p‐Orbital Electron Delocalization Induced by Sulfur Defect Engineering for Enhancing Photoelectrochemical Water Splitting Performance DOI Open Access
Yixuan Gao, Zhaoli Liu, Hua Lü

et al.

Advanced Energy Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Indium sulfide (In 2 S 3 ) as water splitting photocatalyst has been broadly investigated due to its narrow bandgap (2.0–2.3 eV) and optimized opto‐electronic properties. However, In still suffers from a rapid photogenerated charge carrier recombination rate. addition, the main group metals (such In) lack active d ‐orbital electrons for catalysis, thus limits activation of intermediates during catalytic reaction. Herein, overcome above limitations , /TiO heterojunction with sulfur defects are constructed by temperature control strategy. The vacancy (Sv) can induce electron density transformation 5 p localized states delocalized states, which efficiently enhances chemical affinity * OOH. Thus, interaction between O atoms greatly facilitates rate‐determining step ( OOH → +O ), realizing high yield rate 10.00 µmol cm −2 h −1 at 1.23 V versus RHE. Furthermore, heterogeneous structure also enhance interfacial electric field (IEF) stability promoting oxygen generation. This work provides an efficient pathway improve photoelectrochemical (PEC) activity manipulating delocalization through defect engineering.

Language: Английский

A Light‐Triggered J‐Aggregation‐Regulated Therapy Conversion: from Photodynamic/Photothermal Therapy to Long‐Lasting Chemodynamic Therapy for Effective Tumor Ablation DOI

Kai Wei,

Yanxin Wu,

Xian Zheng

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(23)

Published: April 5, 2024

Abstract Reactive oxygen species (ROS) have become an effective tool for tumor treatment. The combination of photodynamic therapy (PDT) and chemodynamic (CDT) takes advantage various ROS enhances therapeutic effects. However, the activation CDT usually occurs before PDT, which hinders sustained maintenance hydroxyl radicals (⋅OH) reduces treatment efficiency. Herein, we present a light‐triggered nano‐system based on molecular aggregation regulation converting cancer from PDT/photothermal (PTT) to long‐lasting CDT. ordered J‐aggregation properties cyanine moiety while simultaneously suppressing capabilities copper‐porphyrin moiety. Upon light irradiation, Cu‐PCy JNPs demonstrate strong photothermal Meanwhile, triggers rapid degradation backbone, leading destruction J‐aggregation. As result, is sequentially activated, generation ⋅OH observed up 48 hours, causing potent cellular oxidative stress apoptosis. Due their excellent accumulation, exhibit in vivo ablation through therapy. This work provides new approach effectively prolonging activity ROS‐based

Language: Английский

Citations

46
Catalyzing Generation and Stabilization of Oxygen Vacancies on CeO2−x Nanorods by Pt Nanoclusters as Nanozymes for Catalytic Therapy DOI Creative Commons
Jiankang Zhang, Yu Yang,

Fengmin Qin

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(31)

Published: Sept. 14, 2023

Abstract Although CeO 2 nanomaterials have been widely explored as nanozymes for catalytic therapy, they still suffer from relatively low activities. Herein, the catalyzing generation and stabilization of oxygen vacancies on nanorods by Pt nanoclusters via H gas reduction under mild temperature (350 °C) to obtain Pt/CeO 2− x , which can serve a highly efficient nanozyme cancer is reported. The deposited atomic layer deposition technique not only catalyst generate through hydrogen spillover effect, but also stabilize generated vacancies. Meanwhile, provide anchoring sites forming strong metal‐support interactions thus preventing their agglomerations. Importantly, reduced at 350 °C (Pt/CeO ‐350R) exhibits excellent enzyme‐mimicking activity reactive species (e.g., ·OH) compared other control samples, including temperatures, achieving performance tumor‐specific therapy efficiently eliminate cells in vitro ablate tumors vivo. ‐350R originates good activities vacancy‐rich nanoclusters.

Language: Английский

Citations

43
Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics DOI

Yifan Di,

Ruizhu Deng,

Zhu Liu

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122391 - 122391

Published: Nov. 15, 2023

Language: Английский

Citations

39
Engineering of Schottky heterojunction in Ru@Bi2S3/Nb2C MXene based on work function with enhanced carrier separation for promoted sterilization DOI

Jiafeng Xi,

Xiaojuan Liu,

Liang Zhang

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 473, P. 145169 - 145169

Published: Aug. 3, 2023

Language: Английский

Citations

35
In-situ constructing hetero-structured Mo2C-Mo2N embedded in carbon nanosheet as an efficient separator modifier for high-performance lithium-sulfur batteries DOI
Wang Zhang, Huiying Li, Runming Tao

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 475, P. 146133 - 146133

Published: Sept. 19, 2023

Language: Английский

Citations

27
Structure Engineered High Piezo‐Photoelectronic Performance for Boosted Sono‐Photodynamic Therapy DOI
Rui Zhang, Dan Yang,

Pengyu Zang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(9)

Published: Nov. 7, 2023

Sono-photodynamic therapy is hindered by the limited tissue penetration depth of external light source and quick recombination electron-hole owing to random movement charge carriers. In this study, orthorhombic ZnSnO

Language: Английский

Citations

24
Peptide‐Functionalized Inorganic Oxide Nanomaterials for Solid Cancer Imaging and Therapy DOI

Xiaolin Duan,

Pin Wang,

Lulu He

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(37)

Published: Feb. 9, 2024

Abstract The diagnosis and treatment of solid tumors have undergone significant advancements marked by a trend toward increased specificity integration imaging therapeutic functions. multifaceted nature inorganic oxide nanomaterials (IONs), which boast optical, magnetic, ultrasonic, biochemical modulatory properties, makes them ideal building blocks for developing multifunctional nanoplatforms. A promising class materials that emerged in this context are peptide‐functionalized (PFIONs), demonstrated excellent performance therapy, making potential candidates advancing tumor treatment. Owing to the functionalities peptides targeting, penetration, responsiveness, well‐designed PFIONs can specifically accumulate release or agents at sites, enabling precise effective This review provides an overview recent advances use tumors, highlighting superiority as well synergistic Moreover, discusses challenges prospects depth, aiming promote intersection interdisciplinary facilitate their clinical translation development personalized diagnostic systems optimizing material systems.

Language: Английский

Citations

12
Defect‐Engineered Tin Disulfide Nanocarriers as “Precision‐Guided Projectile” for Intensive Synergistic Therapy DOI
Yanlin Zhu, Ruoxi Zhao, Lili Feng

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: March 10, 2024

Abstract Nanoformulations with endogenous/exogenous stimulus‐responsive characteristics show great potential in tumor cell elimination minimal adverse effects and high precision. Herein, an intelligent nanotheranostic platform (denoted as TPZ@Cu‐SnS 2‐x /PLL) for microenvironment (TME) near‐infrared light (NIR) activated tumor‐specific therapy is constructed. Copper (Cu) doping the resulting sulfur vacancies can not only improve response range of visible but also separation efficiency photogenerated carriers increase carrier density, ideal photothermal photodynamic performance. Density functional theory calculations revealed that introduction Cu induce electron redistribution, achieving favorable electrons. After entering cells through endocytosis, /PLL nanocomposites pH responsivity property release TPZ selectively within acidic TME, released 2+ first interact local glutathione (GSH) to deplete GSH production + . Subsequently, ‐mediated Fenton‐like reaction decompose hydrogen peroxide into hydroxyl radicals, which be promoted by hyperthermia derived from effect apoptosis. The integration photoacoustic/computed tomography imaging‐guided NIR phototherapy, TPZ‐induced chemotherapy, GSH‐elimination/hyperthermia enhanced chemodynamic results synergistic therapeutic outcomes without obvious systemic toxicity vivo.

Language: Английский

Citations

11
Bi‐Pt Heterojunction Cascade Reaction Platform for Sono‐Immunotherapy of Tumors via PANoptosis and Ferroptosis DOI
Sijia Wu, Qian Wang, Junhui Du

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract Sonodynamic therapy (SDT) represents a promising, noninvasive, and precise treatment modality for tumors, demonstrating significant potential in clinical applications. However, the efficiency of sonosensitizers generating reactive oxygen species (ROS) is often limited by rapid electron‐hole recombination. In this study, BiF 3 @BiOI synthesized via co‐precipitation method, followed in‐situ reduction to decorate it with Pt nanoparticles, resulting @BiOI@Pt‐PVP (BBP) nanocomposite enhancing SDT efficacy. The formation heterojunction enhances charge separation ability. decoration nanoparticles narrows bandgap alters band positions Fermi level BBP, which can effectively mitigate recombination pairs facilitate cascade reaction ROS, thereby improving ROS generation ultrasound excitation. Additionally, bismuth ions BBP generated holes consume glutathione, exacerbating cellular oxidative damage, triggering PANoptosis ferroptosis. Furthermore, demonstrate peroxidase‐like activity, catalyzing endogenous hydrogen peroxide oxygen. These functions are helpful against tumors alleviating hypoxic conditions, reshaping microenvironment, modulating immune cell infiltration capacity, efficacy immunotherapy. dual strategy forming heterojunctions sensitization noble metals sono‐catalytic therapy‐induced activation tumor treatment.

Language: Английский

Citations

10
Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy DOI

Xiaodan Jia,

Yue Wang, Yue Qiao

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Language: Английский

Citations

10