Activatable Molecular Probes With Clinical Promise for NIR‐II Fluorescent Imaging DOI Open Access
Zikang Chen, Yongjie Zhou, Li Li

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

Abstract The second near‐infrared window (NIR‐II) fluorescence imaging has been widely adopted in basic scientific research and preclinical applications due to its exceptional spatiotemporal resolution deep tissue penetration. Among the various fluorescent agents, organic small‐molecule fluorophores are considered most promising candidates for clinical translation, owing their well‐defined chemical structures, tunable optical properties, excellent biocompatibility. However, many currently available NIR‐II exhibit an “always‐on” signal, which leads background noise compromises diagnostic accuracy during disease detection. Developing activatable probes (AOSFPs) accurately reporting pathological changes is key advancing toward application. This review summarizes rational design strategies AOSFPs based on four core structures (cyanine, hemicyanine, xanthene, BODIPY). These hold substantial potential translation. Furthermore, recent advances bioimaging comprehensively reviewed, offering clear guidance direction further development. Finally, prospective efforts advance outlined.

Язык: Английский

Biomarker-driven molecular imaging probes in radiotherapy DOI Creative Commons
Haonan Li, Qiyong Gong, Kui Luo

и другие.

Theranostics, Год журнала: 2024, Номер 14(10), С. 4127 - 4146

Опубликована: Янв. 1, 2024

Biomarker-driven molecular imaging has emerged as an integral part of cancer precision radiotherapy. The use probes, including nanoprobes, have been explored in radiotherapy to precisely and noninvasively monitor spatiotemporal distribution biomarkers, potentially revealing tumor-killing mechanisms therapy-induced adverse effects during radiation treatment.

Язык: Английский

Процитировано

80
Enzyme-activated nanomaterials for MR imaging and tumor therapy DOI

Jingxia Lv,

Renye Yue, Huiyi Liu

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 510, С. 215842 - 215842

Опубликована: Апрель 15, 2024

Язык: Английский

Процитировано

17
Monitoring ROS Responsive Fe3O4‐based Nanoparticle Mediated Ferroptosis and Immunotherapy via 129Xe MRI DOI
Lei Zhang, Maosong Qiu, Ruifang Wang

и другие.

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(22)

Опубликована: Март 29, 2024

The immune checkpoint blockade strategy has improved the survival rate of late-stage lung cancer patients. However, low response limits immunotherapy efficiency. Here, we report a ROS-responsive Fe

Язык: Английский

Процитировано

15
Activated aggregation‐induced emission therapeutics agents for triggering regulated cell death DOI Creative Commons

Yu‐Qiang Zhao,

Le Yu,

Lanyun Zhang

и другие.

Aggregate, Год журнала: 2024, Номер 5(3)

Опубликована: Янв. 22, 2024

Abstract The induction of regulated cell death (RCD) through photo/ultrasound sensitization therapeutic agents has gained significant attention as a vital approach to combat drug resistance in tumors. Aggregation‐induced emission (AIE) generate reactive oxygen species activation, which can synergize with RCD inducers or directly induce RCD, ultimately resulting the tumor cells. presented comprehensive review delves into recent advancements AIE designed trigger inducers, encompassing apoptosis, necroptosis, pyroptosis, immunogenic death, autophagy, ferroptosis, and cuproptosis. Additionally, intricate regulatory mechanisms activatory‐AIE therapeutics influence distinct pathways are examined. A forward‐looking perspective on future developments pertinent challenges within this exciting realm is presented, anticipating continued evolution activatable transformative enhance therapy.

Язык: Английский

Процитировано

14
Recent advances in self‐immobilizing fluorescent probes for in vivo imaging DOI Creative Commons
Yong Zhang,

Xuemei Lv,

Yafu Wang

и другие.

Smart Molecules, Год журнала: 2024, Номер 2(3)

Опубликована: Авг. 23, 2024

Abstract In situ precise detection of bioactive molecules with high sensitivity and spatiotemporal resolution is essential for studying physiological events disease diagnosis. The utilization versatile fluorescent probes in fluorescence imaging offers a powerful tool vivo biomarkers closely associated pathological conditions. However, the dynamic behavior leading to rapid clearance small molecule from regions interest severely compromises their potential imaging. Notably, self‐immobilizing that selectively recognize diseased tissues while improving retention enrichment enable accurate high‐fidelity this review, we aim summarize strategies employed recent advances performance precision using techniques. Lastly, discuss prospects challenges promote further development application more delicate probes.

Язык: Английский

Процитировано

14
A Dual-Cascade Activatable Near-Infrared Fluorescent Probe for Precise Intraoperative Imaging of Tumor DOI

Yanbin Feng,

Haohao Yan,

Xiaocheng Mou

и другие.

Nano Letters, Год журнала: 2024, Номер 24(20), С. 6131 - 6138

Опубликована: Май 10, 2024

Accurate intraoperative tumor delineation is critical to achieving successful surgical outcomes. However, conventional techniques typically suffer from poor specificity and low sensitivity are time-consuming, which greatly affects decision-making. Here, we report a cascade activatable near-infrared fluorescent (NIRF) probe IR780SS@CaP that can sequentially respond acidity elevated glutathione levels for accurate localization. Compared with nonactivatable single-factor probes, strategy minimize nonspecific activation false positive signals in complicated biological environment, affording superior tumor-to-normal tissue ratio facilitate the of abdominal metastases. Small metastatic lesions were less than 1 mm diameter be precisely identified by completely excised under NIRF imaging guidance. This study could benefit diagnosis image-guided surgery providing real-time information reliable decision support, thus reducing risk both recurrence complications improve patient

Язык: Английский

Процитировано

11
A Triple-Responsive and Dual-NIR Emissive Fluorescence Probe for Precise Cancer Imaging and Therapy by Activating Pyroptosis Pathway DOI
Min Deng,

Peipei Wang,

Zibo Zhai

и другие.

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Revealing changes in the tumor microenvironment is crucial for understanding cancer and developing sensitive methods precise imaging diagnosis. Intracellular hydrogen peroxide (H2O2) microenvironmental factors (e.g., viscosity polarity) are closely linked to various physiological pathological processes, making them potential biomarkers cancer. However, a triple-response theranostic probe therapy has not yet been achieved due lack of effective tools. Herein, we present mitochondria-targeting near-infrared (NIR) fluorescent probe, VPH-5DF, capable simultaneously monitoring H2O2, viscosity, polarity through dual NIR channels. The specifically detects H2O2 via emission (λem = 650 nm) shows high sensitivity viscosity/polarity deep channel ≈ 750 nm). Furthermore, only monitors mitochondrial polarity, fluctuations endogenous/exogenous levels but also distinguishes cells from normal multiple parameters. Additionally, VPH-5DF can be employed monitor alterations levels, as well during drug-induced pyroptosis living cells. After treatment with chemotherapy-induced oxidative damage mitochondria activated pathway, leading robust antitumor response, evidenced xenograft models. Thus, this prodrug offers new platform vivo diagnosis anticancer chemotherapy.

Язык: Английский

Процитировано

2
High-fidelity imaging of a tumour-associated lysosomal enzyme with an acceptor engineering-boosted near-infrared fluorescent probe DOI Creative Commons
Feng Bin,

Feiyi Chu,

Yanpeng Fang

и другие.

Chemical Science, Год журнала: 2024, Номер 15(19), С. 7324 - 7331

Опубликована: Янв. 1, 2024

This work reports an acceptor engineering-boosted near-infrared fluorescent probe for high-fidelity imaging of tumour-associated β-galactosidase specifically in lysosomes and vivo .

Язык: Английский

Процитировано

8
β-Galactosidase-Activated and Red Light-Induced RNA Modification Strategy for Prolonged NIR Fluorescence/PET Bimodality Imaging DOI
Jing Fang, Qingzhu Liu, Yaling Liu

и другие.

Analytical Chemistry, Год журнала: 2024, Номер 96(4), С. 1707 - 1716

Опубликована: Янв. 19, 2024

Improving the retention of small-molecule-based therapeutic agents in tumors is crucial to achieve precise diagnosis and effective therapy cancer. Herein, we propose a β-galactosidase (β-Gal)-activated red light-induced RNA modification (GALIRM) strategy for prolonged tumor imaging. A β-Gal-activatable near-infrared (NIR) fluorescence (FL) positron emission tomography (PET) bimodal probe 68Ga-NOTA-FCG consists triaaza triacetic acid chelator NOTA 68Ga-labeling, β-Gal-activated photosensitizer CyGal, singlet oxygen (1O2)-susceptible furan group modification. Studies have demonstrated that emits an activated NIR FL signal upon cleavage by endogenous β-Gal overexpressed lysosomes, which combined with PET imaging 68Ga allowing highly sensitive ovarian Moreover, capability generating 1O2 under 690 nm illumination could be simultaneously unlocked, can trigger covalent cross-linking between nucleotides cytoplasmic RNAs. The formation probe-RNA conjugate effectively prevent exocytosis prolong tumors. We thus believe this GALIRM may provide entirely new insights into long-term efficient treatment.

Язык: Английский

Процитировано

7
Senolytic Therapy Enabled by Senescent Cell‐Sensitive Biomimetic Melanin Nano‐senolytics DOI Creative Commons
Hairui Zhang, Xiaoling Xu, Xin Shou

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Май 26, 2024

Cellular senescence is a significant risk factor for aging and age-related diseases (ARD). The canonical senolytics Dasatinib Quercetin (DQ) have shown promise in clearing senescent cells (SnCs); however, the lack of selectivity poses challenge achieving optimal outcomes. Despite recent occurrence nanomaterial-based approaches targeting SnCs, limited therapeutic effects, potential toxicity still remain major concern. Herein, "double locks-like" nanoplatform developed that integrated Galactan coating mesoporous polydopamine to encase senolytic drug DQ. By this way, DQ only released SnCs are featured with higher levels β-galactosidase (β-gal) low PH. Additionally, nanoparticles equipped 2,2,6,6-Tetramethylpiperidine-1-oxyl (Tempo) gain enhanced photothermal converting potential. Consequently, synthesized nanosenolytics demonstrate remarkable specificity efficacy eradicating accordingly reverse pulmonary fibrosis mice without affecting normal tissues. Upon exposure near-infrared (NIR) light, efficiently remove tumor inducted by chemotherapy, thereby hindering outgrowth metastasis or breast cancer. Collectively, present study develops an "On/Off" switchable response produces more safe, efficient, feasible way delay alleviate age-associated diseases.

Язык: Английский

Процитировано

7