Journal of the American Chemical Society,
Год журнала:
2020,
Номер
142(22), С. 9884 - 9889
Опубликована: Апрель 27, 2020
Palladium-catalyzed
Suzuki–Miyaura
cross-coupling
reactions
of
liquid,
unbiased
dibromoarenes
under
mechanochemical
conditions
selectively
afford
the
monoarylated
products.
The
lower
reactivity
crystalline
products
relative
to
liquid
starting
materials
should
be
attributed
predominantly
low
diffusion
efficiency
former
in
reaction
mixture,
which
results
a
selective
monoarylation.
present
study
sheds
light
on
novel
approach
using
situ
phase
transitions
solids
design
organic
transformations
that
are
difficult
achieve
via
conventional
solution-based
synthesis.
Chemical Science,
Год журнала:
2018,
Номер
9(12), С. 3080 - 3094
Опубликована: Янв. 1, 2018
Mechanochemistry
is
becoming
more
widespread
as
a
technique
for
molecular
synthesis
with
new
mechanochemical
reactions
being
discovered
at
increasing
frequency.
This
perspective
explores
what
it
can
offer,
aside
from
the
clear
benefit
of
reduced
solvent
consumption.
Chemical Reviews,
Год журнала:
2021,
Номер
122(2), С. 2752 - 2906
Опубликована: Авг. 10, 2021
Photoinduced
chemical
transformations
have
received
in
recent
years
a
tremendous
amount
of
attention,
providing
plethora
opportunities
to
synthetic
organic
chemists.
However,
performing
photochemical
transformation
can
be
quite
challenge
because
various
issues
related
the
delivery
photons.
These
challenges
barred
widespread
adoption
steps
industry.
past
decade,
several
technological
innovations
led
more
reproducible,
selective,
and
scalable
photoinduced
reactions.
Herein,
we
provide
comprehensive
overview
these
exciting
advances,
including
flow
chemistry,
high-throughput
experimentation,
reactor
design
scale-up,
combination
photo-
electro-chemistry.
Science,
Год журнала:
2019,
Номер
366(6472), С. 1500 - 1504
Опубликована: Дек. 20, 2019
Over
the
past
decade,
photoredox
catalysis
has
harnessed
light
energy
to
accelerate
bond-forming
reactions.
We
postulated
that
a
complementary
method
for
redox-activation
of
small
organic
molecules
in
response
applied
mechanical
could
be
developed
through
piezoelectric
effect.
Here,
we
report
agitation
materials
via
ball
milling
reduces
aryl
diazonium
salts.
This
mechanoredox
system
can
arylation
and
borylation
reactions
under
mechanochemical
conditions.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(6), С. 4100 - 4140
Опубликована: Янв. 1, 2021
This
review
aims
to
provide
a
field
guide
for
the
implementation
of
mechanochemistry
in
synthetic
polymers
by
summarizing
molecules,
materials,
and
methods
that
have
been
developed
this
field.
Angewandte Chemie International Edition,
Год журнала:
2018,
Номер
58(11), С. 3285 - 3299
Опубликована: Ноя. 12, 2018
Abstract
In
recent
years,
the
application
of
mechanical
energy
to
chemical
systems
has
repeatedly
proven
beneficial
facilitate
transformations
in
various
areas
chemistry.
Today,
a
systematic
body
evidence
indicates
that
mechanochemistry
holds
great
promise
become
game‐changer
synthesis.
Not
only
does
permit
access
products
are
inaccessible
by
established
means
(e.g.
purely
thermal
activation),
mechanochemical
reactions
often
outperform
their
solution‐based
counterparts
terms
sustainability.
Most
carried
out
ball
milling
techniques
involve
solids
and
liquids,
but
number
with
gaseous
reactants
is
increasing.
The
aim
this
Minireview
provide
an
overview
involving
samples
highlight
advances
technology
for
safe
handling
reagents.
Examples
proceeding
at
interface
solid–/liquid–/gas–gas
led
significant
improvements
reactivity
or
selectivity
will
also
be
highlighted.
ACS Catalysis,
Год журнала:
2020,
Номер
10(15), С. 8344 - 8394
Опубликована: Май 27, 2020
The
extraordinary
impact
of
metal-based
complexes
on
synthetic
methods
is
still
recognized
nowadays,
and
attempts
are
currently
undertaken
to
further
extend
the
use
metal-assisted
chemistry
environmentally
friendly
processes
within
strongly
invoked
green
paradigm.
In
recent
years,
mechanochemistry
seems
provide
attractive
responses
with
processing
having
origins
lost
in
mists
time.
Focusing
panorama
organic
synthesis,
this
Review
highlights
some
recently
developed
mechanochemical
reactions
introduce
reader
into
fascinating,
quite
unexplored
world
mechanochemistry.
Advanced Synthesis & Catalysis,
Год журнала:
2021,
Номер
363(5), С. 1246 - 1271
Опубликована: Янв. 21, 2021
Abstract
Mechanochemical
reactions
by
milling,
grinding
or
other
types
of
mechanical
action
have
emerged
as
a
salient
green
approach
because
its
wide
applications
towards
academic
and
industrial
chemical
communities
in
sustainable
solvent‐free/solvent‐less
processes.
Liquid‐assisted
(LAG)
an
extension
traditional
solvent‐free
mechanochemical
techniques
which
small
amount
liquid
is
used
additive
to
enhance
and/or
control
reactivity,
has
been
fruitfully
applied
the
screening
inclusion
compounds,
cocrystals,
salts,
solvates,
polymorphs.
However,
utilization
this
important
technique
synthesis
pharmaceutically
biologically
relevant
targets
was
not
adequately
investigated.
This
review
article
summarizes
overview
latest
development
LAG
approaches
active
pharmaceutical
ingredients
(API)
drug‐like
fragments,
highlights
superiority
versus
conventional
syntheses.
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