Microbial Pathogenesis, Год журнала: 2023, Номер 176, С. 106020 - 106020
Опубликована: Фев. 4, 2023
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 139, С. 111661 - 111661
Опубликована: Май 8, 2021
During the past decade, accumulating evidence from research highlights suggested effects of bacterial communities human gut microbiota and their metabolites on health disease. In this regard, microbiota-derived receptors, beyond immune system, maintain metabolism homeostasis, which is essential to host's by balancing utilization intake nutrients. It has been shown that dysbiosis can cause pathology altered metabolites' formation, resulting in dysregulation system metabolism. The short-chain fatty acids (SCFAs), such as butyrate, acetate, succinate, are produced due fermentation process bacteria gut. noted remodeling associated with pathophysiology several neurological disorders, Alzheimer's disease, multiple sclerosis, Parkinson's amyotrophic lateral stress, anxiety, depression, autism, vascular dementia, schizophrenia, stroke, neuromyelitis optica spectrum among others. This review will discuss current most significant studies dealing some SCFAs microbial selected disorders.
Язык: Английский
Процитировано
267
Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 145, С. 112352 - 112352
Опубликована: Ноя. 26, 2021
A growing body of documents shows microbiota produce metabolites such as short-chain fatty acids (SCFAs) crucial executors diet-based microbial influence the host and bacterial pathogens. The production SCFAs depends on metabolic activity intestinal microflora is also affected by dietary changes. play important roles in maintaining colonic health an energy source, a regulator gene expression cell differentiation, anti-inflammatory agent. Additionally, regulated virulence genes critical for successful infection pathogen. Bacteria rely sensing environmental signals to find preferable niches reach infectious state. This review will present data supporting diverse functional microbiota-derived butyrate, propionate, acetate cellular activities immune modulation, metabolism, nervous system, inflammation, anti-tumor effects, among others. On other hand, we discuss summarize about role these factor In this regard, receptors signaling routes pathogens be introduced.
Язык: Английский
Процитировано
102
Future Virology, Год журнала: 2021, Номер 17(1), С. 49 - 66
Опубликована: Ноя. 26, 2021
This article provides a brief overview of DNA vaccines. First, the basic vaccine design strategies are described, then specific issues related to industrial production vaccines discussed, including and purification products such as plasmid DNA, minicircle minimalistic, immunologically defined gene expression (MIDGE) Doggybone™. The use adjuvants enhance immunogenicity is discussed. In addition, different delivery routes several physical chemical methods increase efficacy into cells explained. Recent preclinical clinical trials for COVID-19 summarized. Lastly, advantages obstacles
Язык: Английский
Процитировано
93
Journal of Neuroimmunology, Год журнала: 2021, Номер 358, С. 577640 - 577640
Опубликована: Июнь 24, 2021
Язык: Английский
Процитировано
85
International Immunopharmacology, Год журнала: 2020, Номер 90, С. 107204 - 107204
Опубликована: Ноя. 13, 2020
Язык: Английский
Процитировано
78
Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 141, С. 111817 - 111817
Опубликована: Июнь 11, 2021
In recent years, an overwhelming amount of evidence has positively recommended a significant role microbiota in human health and disease. Microbiota also plays crucial the initiation, preparation, function host immune response. Recently, it been shown that short-chain fatty acids (SCFAs) are primary metabolites intestinal produced by anaerobic fermentation, which contributes to host-pathogen interaction. SCFAs, such as propionate, acetate, butyrate, bacterial with immunomodulatory activity, they indispensable for maintenance homeostasis. Some indicates involved development infections. present study, we provide latest findings on SCFAs response
Язык: Английский
Процитировано
61
Molecular Medicine, Год журнала: 2022, Номер 28(1)
Опубликована: Янв. 29, 2022
Abstract Background Biofilm is a community of bacteria embedded in an extracellular matrix, which can colonize different human cells and tissues subvert the host immune reactions by preventing detection polarizing towards anti-inflammatory state, promoting persistence biofilm-embedded host. Main body manuscript It now well established that function ultimately mediated cellular metabolism. The are stimulated to regulate their functions upon sensing danger signals. Recent studies have determined often display distinct metabolic alterations impair responses when triggered. Such reprogramming its physiological implications cancer situations. In bacterial infections, immuno-metabolic evaluations primarily focused on macrophages neutrophils planktonic growth mode. Conclusion Based differences inflammatory planktonic- versus biofilm-associated must also consider against biofilm infections. profound characterization cell could offer exciting novel targets for antibiofilm therapy.
Язык: Английский
Процитировано
38
Molecular Biology Reports, Год журнала: 2025, Номер 52(1)
Опубликована: Янв. 12, 2025
Язык: Английский
Процитировано
1
Journal of Medical Virology, Год журнала: 2022, Номер 94(5), С. 1846 - 1865
Опубликована: Янв. 25, 2022
Coronavirus disease 2019 (COVID-19), caused by a highly pathogenic emerging virus, is called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Knowledge regarding the pathogenesis of this virus in infancy; however, investigation on mechanisms SARS-CoV-2 underway. In COVID-19, one most remarkable characteristics wide range manifestation and severity seen across individuals different ethnic backgrounds geographical locations. To effectively manage COVID-19 populations, beyond detection, serological response assessment, analytic techniques, it critical to obtain knowledge about at-risk comprehend identified variations disease's general also populations' levels. Several factors can contribute variation presentation, including population density, gender age differences, comorbid circumstances diabetes mellitus, hypertension, obesity. Genetic presumably influence infection susceptibility. Besides this, has been linked with higher risk mortality men certain groups, revealing that host genetic may affect individual death. Also, variants involved pathologic processes, entrance into cells, antiviral immunity, inflammatory response, are not entirely understood. Regarding characteristics, present review suggests various polymorphisms pathogenicity which might have significant implications for understanding interpreting matter genetics customized integrative medical care based investigation.
Язык: Английский
Процитировано
36
Journal of Medical Virology, Год журнала: 2022, Номер 94(10), С. 4611 - 4627
Опубликована: Июнь 11, 2022
The field of immunometabolism investigates and describes the effects metabolic rewiring in immune cells throughout activation fates these cells. Recently, it has been appreciated that plays an essential role progression viral infections, cancer, autoimmune diseases. Regarding COVID-19, aberrant response underlying diseases establishes two major respiratory pathologies, including acute distress syndrome (ARDS) or pneumonia-induced lung injury (ALI). Both innate adaptive immunity (T cell-based) were impaired course severe coronavirus 2 (SARS-CoV-2) infection. Current findings have deciphered macrophages (innate cells) are involved inflammatory seen COVID-19. It demonstrated system can change reprogramming some conditions, diseases, infectious disease, growing on COVID-19 allow exploration metabolites with immunomodulatory properties as future therapies to combat this hyperinflammatory response. elucidation exact mechanism reprograming could help apply more precise approaches initial diagnosis, prognosis, in-hospital therapy. This report discusses latest from host immunometabolic responses.
Язык: Английский
Процитировано
34