Frontiers in Microbiology,
Год журнала:
2022,
Номер
13
Опубликована: Март 30, 2022
Probiotics
have
been
shown
to
be
effective
against
infectious
diseases
in
clinical
trials,
with
either
intestinal
or
extraintestinal
health
benefits.
Even
though
probiotic
effects
are
strain-specific,
some
"widespread
effects"
include:
pathogen
inhibition,
enhancement
of
barrier
integrity
and
regulation
immune
responses.
The
mechanisms
involved
the
benefits
probiotics
not
completely
understood,
but
these
can
mediated,
at
least
part,
by
probiotic-derived
extracellular
vesicles
(EVs).
However,
date,
there
no
trials
examining
EVs
diseases.
There
is
still
a
long
way
go
bridge
gap
between
basic
research
practice.
This
review
attempts
summarize
current
knowledge
about
released
bacteria
understand
their
possible
role
prevention
and/or
treatment
A
better
understanding
whereby
package
cargo
process
communication
host
cells
(inter-kingdom
communication),
would
allow
further
advances
this
field.
In
addition,
we
comment
on
potential
use
missing
as
therapeutic
agents
(postbiotics)
Future
needed
open
new
avenues
for
encapsulation
bioactives
inside
from
GRAS
(Generally
Regarded
Safe)
bacteria.
could
scientific
novelty
applications
functional
foods
pharmaceutical
industries.
Journal of Extracellular Vesicles,
Год журнала:
2021,
Номер
10(13)
Опубликована: Ноя. 1, 2021
The
intestine
is
fundamental
in
controlling
human
health.
Intestinal
epithelial
and
immune
cells
are
continuously
exposed
to
millions
of
microbes
that
greatly
impact
on
intestinal
barrier
function.
This
microbial
community,
known
as
gut
microbiota,
now
recognized
an
important
partner
the
being
actively
contribute
essential
functions
but
also
distal
organs.
In
ecosystem,
bidirectional
microbiota-host
communication
does
not
involve
direct
cell
contacts.
Both
microbiota
host-derived
extracellular
vesicles
(EVs)
key
players
such
interkingdom
crosstalk.
There
accumulating
body
evidence
bacterial
secreted
mediate
by
transporting
delivering
into
host
effector
molecules
modulate
signalling
pathways
processes.
Consequently,
released
may
have
great
influence
health
disease.
Here
we
review
current
knowledge
EVs
specifically
highlight
their
role
metabolism,
integrity
training.
Journal of Translational Medicine,
Год журнала:
2022,
Номер
20(1)
Опубликована: Март 7, 2022
Abstract
The
human
gastrointestinal
tract
is
inhabited
by
the
largest
microbial
community
within
body
consisting
of
trillions
microbes
called
gut
microbiota.
normal
flora
site
many
physiological
functions
such
as
enhancing
host
immunity,
participating
in
nutrient
absorption
and
protecting
against
pathogenic
microorganisms.
Numerous
investigations
showed
a
bidirectional
interplay
between
microbiota
organs
intestines,
lungs,
brain,
skin.
Large
evidence
demonstrated,
more
than
decade
ago,
that
alteration
key
factor
pathogenesis
local
systemic
disorders.
In
this
regard,
deep
understanding
mechanisms
involved
symbiosis/dysbiosis
crucial
for
clinical
health
field.
We
review
most
recent
studies
on
involvement
diseases.
also
elaborate
different
strategies
used
to
manipulate
prevention
treatment
future
medicine
strongly
related
quality
our
Targeting
dysbiosis
will
be
huge
challenge.
Bioactive Materials,
Год журнала:
2021,
Номер
14, С. 169 - 181
Опубликована: Дек. 17, 2021
Nanosized
extracellular
vesicles
derived
from
bacteria
contain
diverse
cargo
and
transfer
intercellular
bioactive
molecules
to
cells.
Due
their
favorable
interactions,
cell
membrane-derived
bacterial
(BEVs)
have
great
potential
become
novel
drug
delivery
platforms.
In
this
review,
we
summarize
the
biogenesis
mechanism
compositions
of
various
BEVs.
addition,
an
overview
effective
isolation
purification
techniques
BEVs
is
provided.
particular,
focus
on
application
as
nanocarriers
for
delivery.
Finally,
advances
challenges
after
providing
a
comprehensive
discussion
in
each
section.
We
believe
that
deeper
understanding
will
open
new
avenues
exploitation
applications.
Microbiology Spectrum,
Год журнала:
2022,
Номер
10(4)
Опубликована: Июнь 28, 2022
This
study
indicated
that
C.
butyricum
provided
a
prevention
effect
against
colitis
mice,
which
involved
protection
of
the
intestinal
barrier
and
positively
regulating
gut
microbiota.
Furthermore,
we
confirmed
microbiota
metabolites
were
induced
by
also
contributed
to
attenuation
DSS-induced
colitis.
Importantly,
-derived
EVs
showed
an
effective
impact
in
alleviating
Reviews in Aquaculture,
Год журнала:
2022,
Номер
15(2), С. 820 - 839
Опубликована: Ноя. 8, 2022
Abstract
The
gut
microbiota
is
currently
one
of
the
most
studied
‘organs’
in
animals,
and
fish
are
no
exception.
A
complex
diversity
microbes,
including
bacteria,
archaea,
yeast
fungus,
constitute
microbiota,
creating
a
interaction
with
their
host
accomplishing
multiple
beneficial
functions,
such
as
food
digestion,
nutrient
absorption,
immune
system,
endocrine
stress
response.
microbiota–pathogen
protects
by
mounting
colonization
resistance,
competing
for
nutrients
space.
Changes
balance
community
could
affect
structure
homeostasis,
inducing
dysbiosis.
In
addition,
invading
pathogens
can
induce
dysbiosis
evading
host's
defence
barriers,
acquiring
from
host,
using
metabolites
produced
producing
toxins.
this
regard,
understanding
interactions
within
essential
to
prevent
pathogen
establishment
host.
Hence,
review
describes
close
indivisible
relationships
between
that
lead
disease.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 4751 - 4778
Опубликована: Авг. 1, 2023
Abstract:
Exosomes,
as
natural
nanocarriers,
characterized
with
low
immunogenicity,
non-cytotoxicity
and
targeted
delivery
capability,
which
have
advantages
over
synthetic
nanocarriers.
Recently,
exosomes
shown
great
potential
diagnostic
markers
for
diseases
are
also
considered
a
promising
cell-free
therapy.
Engineered
significantly
enhanced
the
efficacy
precision
of
delivering
therapeutic
agents,
currently
being
extensively
employed
in
investigations
various
ailments,
including
oncology,
inflammatory
disorders,
degenerative
conditions.
Particularly,
engineered
enable
agent
loading,
modification,
evasion
MPS
phagocytosis,
intelligent
control,
bioimaging,
been
developed
multifunctional
nano-delivery
platforms
recent
years.
The
utilization
bioactive
scaffolds
that
loaded
exosome
has
to
substantially
augment
retention,
extend
release,
enhance
efficacy.
This
approach
advanced
from
conventional
hydrogels
nanocomposite
hydrogels,
nanofiber
3D
printing,
resulting
superior
physical
biological
properties
effectively
address
limitations
scaffolds.
Additionally,
plant-derived
exosomes,
can
participate
gut
flora
remodeling
via
oral
administration,
an
ideal
platform
treatment
intestinal
diseases.
Consequently,
there
is
interest
nanocarriers
applications.
comprehensive
review
provides
overview
biogenesis,
composition,
isolation
methods
exosomes.
it
examines
pathological
mechanisms
diseases,
tumors,
Furthermore,
this
highlights
significance
microbial-derived
Strategies
specific
applications
scaffold-loaded
further
summarized,
especially
some
new
techniques
such
large-scale
loading
technique,
macromolecular
development
nano-scaffold-loaded
delivery.
benefits
using
gut-related
discussed.
challenges,
opportunities,
prospects
exosome-based
disease
diagnosis
summarized
both
preclinical
clinical
viewpoints.
Keywords:
diagnosis,
