Progress in biomaterials inspired by the extracellular matrix

Giant, Год журнала: 2024, Номер 19, С. 100323 - 100323

Опубликована: Июль 10, 2024

Inspired by the extracellular matrix (ECM), biomaterials have emerged as promising strategies in biomedical research and engineering domain, offering unique characteristics for tissue regeneration, drug delivery, therapeutic interventions, cellular investigations. The ECM, a dynamic network structure secreted various cells, primarily comprises diverse proteins capable of facilitating tissue-ECM signaling regulatory functions through its rich array bioactive substances multi-level structural properties. Drawing inspiration from intricate biochemical composition natural researchers developed to encapsulate these features create biomimetic microenvironments, such electrospinning, hydrogels/hydrogel microspheres, decellularized ECM(dECM), ECM-mimicking peptides. Furthermore, mimicking ECM components, ECM-inspired exhibit varying degrees functionalization, including providing support, cell adhesion, signal transduction, mitigating immune responses, remodeling. In summary, advancements offer significant promise addressing key challenges fields engineering, regenerative medicine, delivery.

Язык: Английский

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Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings

Gels, Год журнала: 2025, Номер 11(2), С. 123 - 123

Опубликована: Фев. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Язык: Английский

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New Perspectives of Hydrogels in Chronic Wound Management

Molecules, Год журнала: 2025, Номер 30(3), С. 686 - 686

Опубликована: Фев. 4, 2025

Chronic wounds pose a substantial healthcare concern due to their prevalence and cost burden. This paper presents detailed overview of chronic emphasizes the critical need for novel therapeutic solutions. The pathophysiology wound healing is discussed, including stages factors contributing chronicity. focus on diverse types wounds, such as diabetic foot necrosis, pressure ulcers, venous leg highlighting etiology, consequences, issues they provide. Further, modern care solutions, particularly hydrogels, are highlighted tackling challenges management. Hydrogels characterized multipurpose materials that possess vital characteristics like capacity retain moisture, biocompatibility, incorporation active drugs. Hydrogels’ effectiveness in applications demonstrated by how support healing, preserving ideal moisture levels, promoting cellular migration, possessing antibacterial properties. Thus, this hydrogel technology’s latest developments, emphasizing drug-loaded stimuli-responsive underscoring these advanced formulations greatly improve therapy outcomes enabling dynamic focused reactions environment. Future directions research promote development customized treatments digital health tools treatment wounds.

Язык: Английский

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Injectable and pH-responsive self-assembled peptide hydrogel for promoted tumor cell uptake and enhanced cancer chemotherapy

Biomaterials Science, Год журнала: 2022, Номер 10(3), С. 854 - 862

Опубликована: Янв. 1, 2022

Chemotherapy is the main treatment for cancer therapy. However, its anti-tumor efficiency always impaired by poor bioavailability and low tumor accumulation of chemotherapeutic drugs. The variation between microenvironment normal tissue has been recognized as an effective tool to improve drug efficiency. Herein, we developed injectable, pH-responsive, in situ self-assembled drug-peptide hydrogel (MTX-KKFKFEFEF(DA)) highly efficient local chemotherapy with few side effects. small molecule drug, methotrexate (MTX), pH-responsive linker, 2,3-dimethylmaleic anhydride (DA), were facilely conjugated onto chain KKFKFEFEF peptide via amidation reaction. negatively charged (pH 7.4) can be activated positive achieve a sol-gel phase transition under acidic 6.5) both vitro vivo, resulting cellular uptake endocytosis capacities. Moreover, vivo therapeutic effect revealed that MTX-KKFKFEFEF(DA) exhibits long-term retention time, much better inhibition rate negligible effects after intratumoral injection into breast tumor-bearing mice. Therefore, this study reveals versatile strategy fabricating efficacy drugs treatment.

Язык: Английский

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An Injectable Thermosensitive Hydrogel Containing Resveratrol and Dexamethasone‐Loaded Carbonated Hydroxyapatite Microspheres for the Regeneration of Osteoporotic Bone Defects

Small Methods, Год журнала: 2023, Номер 8(1)

Опубликована: Окт. 6, 2023

Abstract Bone defects in osteoporosis usually present excessive reactive oxygen species (ROS), abnormal inflammation levels, irregular shapes and impaired bone regeneration ability; therefore, osteoporotic are difficult to repair. In this study, an injectable thermosensitive hydrogel poly (D, L‐lactide)‐poly (ethylene glycol)‐ L‐lactide) (PLEL) system containing resveratrol (Res) dexamethasone (DEX) is designed create a microenvironment conducive osteogenesis defects. This PLEL injected filled defect areas achieving rapid sol‐gel transition situ. Res has strong anti‐inflammatory effects that can effectively remove excess free radicals at the damaged site, guide macrophage polarization M2 phenotype, regulate immune responses. Additionally, DEX promote osteogenic differentiation. vitro experiments showed promoted differentiation of mesenchymal stem cells, removed intracellular ROS, regulated reduce inflammatory vivo modulated Overall, study confirmed treat by synergistically modulating damage microenvironment, alleviating responses, promoting osteogenesis; thus, it represents promising drug delivery strategy repair

Язык: Английский

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Application of Polymer Hydrogels in the Prevention of Postoperative Adhesion: A Review

Gels, Год журнала: 2023, Номер 9(2), С. 98 - 98

Опубликована: Янв. 23, 2023

Postoperative adhesion is a common post-surgery complication formed between the surface of body cavity, ranging from layer connective tissue to fibrous bridge containing blood vessels and nerve tissue. Despite achieving lot progress, mechanisms formation still need be further studied. In addition, few current treatments are consistently effective in prevention postoperative adhesion. Hydrogel kind water-expanding crosslinked hydrophilic polymer network generated by simple reaction one or more monomers. Due porous structure, hydrogels can load different drugs control drug release kinetics. Evidence existing studies has confirmed feasibility superiority using counter adhesions, primarily due their outstanding antifouling ability. this review, research status as anti-adhesion barriers summarized, character briefly introduced, future directions discussed.

Язык: Английский

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Antibacterial, biocompatible, hemostatic, and tissue adhesive hydrogels based on fungal-derived carboxymethyl chitosan-reduced graphene oxide-polydopamine for wound healing applications

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 241, С. 124641 - 124641

Опубликована: Апрель 28, 2023

Язык: Английский

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Stimuli-Responsive Polysaccharide Hydrogels and Their Composites for Wound Healing Applications

Polymers, Год журнала: 2023, Номер 15(4), С. 986 - 986

Опубликована: Фев. 16, 2023

There is a growing concern about wound care, since traditional dressings such as bandages and sutures can no longer meet existing needs. To address the demanding requirements, naturally occurring polymers have been extensively exploited for use in modern management. Polysaccharides, being most abundant biopolymers, some distinct characteristics, including biocompatibility biodegradability, which render them ideal candidates healing applications. Combining with inorganic organic moieties produce effective multifunctional composites desired mechanical properties, high efficiencies excellent antibacterial behavior. Recent research endeavors focus on development of stimuli-responsive polysaccharide biomedical Polysaccharide composites, sensitive to local environment, changes solution temperature, pH, etc., sense react conditions, thus promoting an interaction wound. This review highlights recent advances hydrogels their The synthetic approaches, physical, chemical, biochemical properties well function will be discussed.

Язык: Английский

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Laponite-Based Nanocomposite Hydrogels for Drug Delivery Applications

Pharmaceuticals, Год журнала: 2023, Номер 16(6), С. 821 - 821

Опубликована: Май 31, 2023

Hydrogels are widely used for therapeutic delivery applications due to their biocompatibility, biodegradability, and ability control release kinetics by tuning swelling mechanical properties. However, clinical utility is hampered unfavorable pharmacokinetic properties, including high initial burst difficulty in achieving prolonged release, especially small molecules (<500 Da). The incorporation of nanomaterials within hydrogels has emerged as viable option a method trap therapeutics the hydrogel sustain kinetics. Specifically, two-dimensional nanosilicate particles offer plethora beneficial characteristics, dually charged surfaces, degradability, enhanced properties hydrogels. nanosilicate–hydrogel composite system offers benefits not obtainable just one component, highlighting need detail characterization these nanocomposite This review focuses on Laponite, disc-shaped with diameter 30 nm thickness 1 nm. using Laponite explored, well examples Laponite–hydrogel composites currently being investigated prolong macromolecules such proteins. Future work will further characterize interplay between nanosilicates, polymer, encapsulated therapeutics, how each components affect

Язык: Английский

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Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications

Biomaterials Science, Год журнала: 2023, Номер 12(1), С. 8 - 56

Опубликована: Окт. 25, 2023

Hydrogels have established their significance as prominent biomaterials within the realm of biomedical research. However, injectable hydrogels garnered greater attention compared with conventional counterparts due to excellent minimally invasive nature and adaptive behavior post-injection. With rapid advancement emerging chemistry deepened understanding biological processes, contemporary been endowed an "intelligent" capacity respond various endogenous/exogenous stimuli (such temperature, pH, light magnetic field). This innovation has spearheaded revolutionary transformations across fields such tissue engineering repair, controlled drug delivery, disease-responsive therapies, beyond. In this review, we comprehensively expound upon raw materials (including natural synthetic materials) principles these advanced hydrogels, concurrently providing a detailed discussion prevalent strategies for conferring stimulus responsiveness. Finally, elucidate latest applications "smart" stimuli-responsive in domain, offering insights into prospects.

Язык: Английский

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