Environment International,
Год журнала:
2024,
Номер
184, С. 108444 - 108444
Опубликована: Янв. 19, 2024
There
is
a
growing
concern
within
the
medical
community
about
potential
burden
of
microplastics
on
human
organs
and
tissues.
In
this
study,
we
investigated
by
microRaman
spectroscopy
presence
in
kidneys
urine.
Moreover,
an
open-access
software
was
developed
validated
for
project,
which
enabled
comparison
between
spectra
self-created
spectral
database,
thus
enhancing
ability
to
characterize
polymers
pigments
biological
matrices.
Healthy
portions
ten
obtained
from
nephrectomies,
as
well
urine
samples
healthy
donors
were
analyzed:
26
particles
both
kidney
identified,
with
sizes
ranging
3
13
μm
1
29
kidneys.
The
most
frequently
determined
are
polyethylene
polystyrene,
while
common
hematite
Cu-phthalocyanine.
This
preclinical
study
proves
renal
tissues
confirms
their
urine,
providing
first
evidence
deposition
humans.
The Science of The Total Environment,
Год журнала:
2023,
Номер
889, С. 164292 - 164292
Опубликована: Май 20, 2023
Studies
on
airborne
microplastics
(AMPs)
have
reported
higher
abundance
of
AMPs
in
indoor
air
compared
to
outdoors.
Most
people
spend
more
time
indoors
outdoors,
and
it
is
therefore
important
identify
quantify
understand
human
exposure
AMPs.
This
can
vary
among
different
individuals
as
they
their
locations
activity
levels,
thus
experience
breathing
rates.
In
this
study,
ranging
from
20
5000
μm
were
sampled
across
sites
Southeast
Queensland
using
an
active
sampling
technique.
The
highest
MP
concentration
was
observed
at
the
childcare
site
(2.25
±
0.38
particles/m3),
followed
by
office
(1.20
0.14
particles/m3)
a
school
(1.03
0.40
particles/m3).
lowest
inside
vehicle
(0.20
comparable
outdoor
concentrations.
only
shapes
fibers
(98
%)
fragments.
ranged
71
4950
length.
Polyethylene
terephthalate
prominent
polymer
type
most
sites.
Using
our
measured
concentrations
inhaled
concentrations,
we
calculated
annual
levels
scenario-specific
levels.
Males
between
ages
18
64
AMP
3187
594
particles/year,
males
≥65
years
2978
628
particles/year.
1928
549
for
females
5
17.
study
provides
first
report
various
types
where
time.
Considering
acute,
chronic,
industrial,
individual
susceptibility,
detailed
inhalation
should
be
estimated
realistic
appraisal
health
risk,
including
how
much
particles
are
exhaled.
Limited
research
exists
occurrence
associated
reports
EBioMedicine,
Год журнала:
2024,
Номер
103, С. 105118 - 105118
Опубликована: Апрель 13, 2024
BackgroundMicroplastic
(MP)
pollution
has
emerged
as
a
significant
environmental
concern
worldwide.
While
extensive
research
focused
on
their
presence
in
marine
organisms
and
ecosystems,
potential
impact
human
health,
particularly
the
circulatory
system,
remains
understudied.
This
project
aimed
to
identify
quantify
mass
concentrations,
polymer
types,
physical
properties
of
MPs
thrombi
surgically
retrieved
from
both
arterial
venous
systems
at
three
anatomically
distinct
sites,
namely,
cerebral
arteries
brain,
coronary
heart,
deep
veins
lower
extremities.
Furthermore,
this
study
investigate
association
between
levels
disease
severity.MethodsThrombus
samples
were
collected
30
patients
who
underwent
thrombectomy
procedures
due
ischaemic
stroke
(IS),
myocardial
infarction
(MI),
or
vein
thrombosis
(DVT).
Pyrolysis–gas
chromatography
spectrometry
(Py-GC/MS)
was
employed
concentrations
MPs.
Laser
direct
infrared
(LDIR)
spectroscopy
scanning
electron
microscopy
(SEM)
used
analyse
Demographic
clinical
information
also
examined.
A
rigorous
quality
control
system
eliminate
contamination.FindingsMPs
detected
by
Py-GC/MS
80%
(24/30)
obtained
with
IS,
MI,
DVT,
median
61.75
μg/g,
141.80
69.62
respectively.
Among
10
target
types
MP
polymers,
polyamide
66
(PA66),
polyvinyl
chloride
(PVC),
polyethylene
(PE)
identified.
Further
analyses
suggested
that
higher
may
be
associated
greater
severity
(adjusted
β
=
7.72,
95%
CI:
2.01–13.43,
p
<
0.05).
The
level
D-dimer
MP-detected
group
significantly
than
MP-undetected
(8.3
±
1.5
μg/L
vs
6.6
0.5
μg/L,
0.001).
Additionally,
LDIR
analysis
showed
PE
dominant
among
15
identified
MPs,
accounting
for
53.6%
all
mean
diameter
35.6
μm.
shapes
polymers
using
SEM
found
heterogeneous.InterpretationThis
presents
qualitative
quantitative
evidence
thrombotic
diseases
through
use
multimodal
detection
methods.
Higher
increased
severity.
Future
larger
sample
size
is
urgently
needed
sources
exposure
validate
observed
trends
study.FundingThis
funded
SUMC
Scientific
Research
Initiation
Grant
(SRIG,
No.
009-510858038),
Postdoctoral
(No.
202205230031-3),
2020
Li
Ka
Shing
Foundation
Cross-Disciplinary
2020LKSFG02C).
Environmental Chemistry Letters,
Год журнала:
2024,
Номер
22(4), С. 1861 - 1888
Опубликована: Апрель 4, 2024
Abstract
Microplastics
are
emerging
contaminants
that
undergo
progressive
aging
under
environmental
conditions
such
as
sunlight
irradiation,
mechanical
forces,
temperature
variations,
and
the
presence
of
biological
organisms.
Since
modifies
microplastic
properties,
their
own
toxicity
trapped
pollutants,
advanced
methods
to
analyze
microplastics
required.
Here
we
review
with
focus
on
process,
qualitative
identification,
quantitative
characterization,
chemometrics.
Qualitative
identification
is
done
by
techniques,
thermal
e.g.,
degradation
gas
chromatography–mass
spectrometry,
spectral
infrared,
Raman,
fluorescent,
laser
techniques.
Quantitative
characterization
microscopy
mass
spectrometry.
Microplastic
results
in
a
series
surface
physical
changes,
biofilm
formation,
chemical
oxidation,
alternation,
deterioration.
Changes
properties
allow
differentiate
aged
microplastics.
Infrared
Raman
spectroscopy
rapid
sensitive
for
complex
samples.
Combining
two
techniques
preferable
accurate
detection
categorization.
