Chemical Society Reviews,
Год журнала:
2020,
Номер
49(8), С. 2273 - 2290
Опубликована: Янв. 1, 2020
Modulating
nanomedicine
mechanical
properties
for
enhanced
drug
delivery
to
tumors
has
attracted
increasing
attention
in
the
past
few
decades.
In
this
tutorial
review,
we
analyze
impact
of
on
vivo
transport
processes
and
highlight
most
recent
advances
efficiency
antitumor
efficacy.
Typical
nanoparticles
that
have
been
explored
purpose
since
2000
are
summarized
while
methods
tune
techniques
characterize
introduced.
end,
challenges
perspectives
tailoring
tumor
targeting
discussed.
Advanced Materials,
Год журнала:
2020,
Номер
32(40)
Опубликована: Авг. 28, 2020
Macrophages
play
an
important
role
in
cancer
development
and
metastasis.
Proinflammatory
M1
macrophages
can
phagocytose
tumor
cells,
while
anti-inflammatory
M2
such
as
tumor-associated
(TAMs)
promote
growth
invasion.
Modulating
the
immune
microenvironment
through
engineering
is
efficacious
therapy.
target
cancerous
cells
and,
therefore,
be
used
drug
carriers
for
Herein,
strategies
to
engineer
immunotherapy,
inhibition
of
macrophage
recruitment,
depletion
TAMs,
reprograming
blocking
CD47-SIRPα
pathway,
are
discussed.
Further,
recent
advances
delivery
using
macrophages,
macrophage-derived
exosomes,
macrophage-membrane-coated
nanoparticles
elaborated.
Overall,
there
still
significant
room
macrophage-mediated
modulation
delivery,
which
will
further
enhance
current
therapies
against
various
malignant
solid
tumors,
including
drug-resistant
tumors
metastatic
tumors.
Theranostics,
Год журнала:
2022,
Номер
12(5), С. 2115 - 2132
Опубликована: Янв. 1, 2022
Platinum-based
drugs
cisplatin,
carboplatin,
and
oxaliplatin
are
widely
used
for
chemotherapeutic
eradication
of
cancer.However,
the
side
effects
platinum
drugs,
such
as
lack
selectivity,
high
systemic
toxicity,
drug
resistance,
seriously
limit
their
clinical
application.With
advancements
in
nanotechnology
chemical
synthesis,
Pt-based
anti-cancer
have
made
great
progress
cancer
therapy
recent
years.Many
strategies
relied
on
mechanism
similar
to
cisplatin
achieved
some
success
by
modifying
existing
drugs.Pt-based
nanodrugs,
nanoclusters,
novel
mechanisms
potential
tumor-targeted
shown
promising
results
application.In
this
review,
we
systematically
explored
development
first-line
chemotherapy
clinic
mechanisms.We
also
summarize
application
therapy,
emphasizing
modification
enhance
anti-tumor
effect.Finally,
address
challenges
faced
especially
Pt
nanocluster-based
treatment.The
new
targeted
modifications
undoubtedly
provide
a
prospect
improving
current
treatments.
Angewandte Chemie International Edition,
Год журнала:
2020,
Номер
59(15), С. 5890 - 5900
Опубликована: Фев. 4, 2020
Abstract
Two‐dimensional
(2D)
nanomaterials
are
currently
explored
as
novel
photothermal
agents
because
of
their
ultrathin
structure,
high
specific
surface
area,
and
unique
optoelectronic
properties.
In
addition
to
single
therapy
(PTT),
2D
have
demonstrated
significant
potential
in
PTT‐based
synergistic
therapies.
this
Minireview,
we
summarize
the
recent
progress
for
enhanced
cancer
over
last
five
years.
Their
optical
properties,
typical
synthesis
methods,
modification
also
covered.
Emphasis
is
placed
on
PTT
PTT‐synergized
chemotherapy,
photodynamic
therapy,
immunotherapy.
The
major
challenges
addressed
promising
prospects
presented.
Advanced Materials,
Год журнала:
2019,
Номер
31(15)
Опубликована: Фев. 18, 2019
Photodynamic
therapy
(PDT)
is
a
promising
anticancer
treatment
and
clinically
approved
for
different
types
of
tumors.
However,
current
PDT
suffers
several
obstacles,
including
its
neutralization
by
excess
glutathione
(GSH)
in
the
tumor
tissue
strongly
proangiogenic
response.
In
this
work,
biomimic,
multifunctional
nanoparticle-based
agent,
combining
tumor-targeted
photosensitizer
with
GSH
scavenging
antiangiogenesis
therapy,
developed.
A
porphyrinic
Zr-metal-organic
framework
nanoparticle
used
simultaneously
as
delivery
vehicle
vascular
endothelial
growth
factor
receptor
2
(VEGFR2)
inhibitor
apatinib.
The
core
nanoparticles
are
wrapped
MnO2
to
consume
intratumoral
then
decorated
cell
membrane
camouflage.
After
intravenous
administration,
selectively
accumulate
through
homotypic
targeting
mediated
biomimic
decoration,
combination
enhanced
antiangiogenic
drug
significantly
improves
their
inhibition
efficiency.
This
study
provides
an
integrated
solution
mechanism-based
enhancement
demonstrates
encouraging
potential
nanosystem
applicable
therapy.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(4), С. 2839 - 2891
Опубликована: Янв. 1, 2021
Supramolecular
cancer
nanotheranostics
have
shown
promising
potentials
in
early-stage
diagnosis
and
personal
therapy.
Herein,
we
summarize
the
progress
of
supramolecular
provide
guidance
for
designing
new
targeted
theranostic
agents.
Journal of Nanobiotechnology,
Год журнала:
2021,
Номер
19(1)
Опубликована: Май 29, 2021
Abstract
In
this
article,
we
will
describe
the
properties
of
albumin
and
its
biological
functions,
types
sources
that
can
be
used
to
produce
nanoparticles,
methods
producing
therapeutic
applications
importance
nanoparticles
in
production
pharmaceutical
formulations.
view
increasing
use
Abraxane
approval
for
treatment
several
cancer
during
final
stages
clinical
trials
other
cancers,
evaluate
it
compare
effectiveness
with
conventional
non
formulations
chemotherapy
Paclitaxel
is
paid.
examine
role
animal
proteins
Nano
medicine
various
benefits
these
biomolecules
preparation
drug
delivery
carriers
characteristics
plant
protein
cages
their
potentials
diagnosis
treatment.
Finally,
advantages
disadvantages
are
mentioned,
as
well
Advanced Materials,
Год журнала:
2019,
Номер
31(40)
Опубликована: Авг. 18, 2019
Activatable
theranostic
agents
that
can
be
activated
by
tumor
microenvironment
possess
higher
specificity
and
sensitivity.
Here,
activatable
nanozyme-mediated
2,2'-azino-bis
(3-ethylbenzothiazoline-6-sulfonic
acid)
(ABTS)
loaded
ABTS@MIL-100/poly(vinylpyrrolidine)
(AMP)
nanoreactors
(NRs)
are
developed
for
imaging-guided
combined
therapy.
The
as-constructed
AMP
NRs
specifically
the
through
a
"two-step
rocket-launching-like"
process
to
turn
on
its
photoacoustic
imaging
signal
photothermal
therapy
(PTT)
function.
In
addition,
simultaneously
producing
hydroxyl
radicals
in
response
high
H2
O2
level
of
disrupting
intracellular
glutathione
(GSH)
endows
with
ability
enhanced
chemodynamic
(ECDT),
thereby
leading
more
efficient
therapeutic
outcome
combination
tumor-triggered
PTT.
More
importantly,
-activated
acid-enhanced
properties
enable
specific
tumors,
leaving
normal
tissues
unharmed.
These
remarkable
features
may
open
new
avenue
explore
nanozyme-involved
intelligent,
accurate,
noninvasive
cancer
theranostics.
ACS Applied Bio Materials,
Год журнала:
2019,
Номер
2(6), С. 2317 - 2338
Опубликована: Май 6, 2019
Carbon
dots
(CDs)
are
relatively
new
and
one
of
the
most
propitious
nanomaterials
ever
known
to
humanity,
primarily
consisting
a
carbonized
carbon
core
with
heteroatoms
in
organic
functional
groups
attached.
CDs
show
various
fascinating
properties,
such
as
tunable
excitation/emission,
chemical
inertness,
photostability,
low
toxicity,
good
biocompatibility,
ease
handling,
eco-friendliness.
Due
anomalous
optical
properties
CDs,
they
have
wide
range
applications
fields
bioimaging,
biosensing,
photocatalysis,
optoelectronics,
etc.
In
this
Review,
we
intend
cover
many
strides
chemistry,
which
is
an
emerging
paradigm,
conjunction
recent
discoveries
near-infrared
fluorescence,
phosphorescence,
electroluminescence,
chirality,
antibacterial
activity.
Our
main
emphasis
will
be
on
contemporary
evolution
synthetic
strategies,
biomedical
nanomedicine
nanotheranostics.
