Subjective and objective sleep and circadian parameters as predictors of depression-related outcomes: A machine learning approach in UK Biobank DOI Creative Commons
Laura M. Lyall, Natasha Sangha, Xingxing Zhu

и другие.

Journal of Affective Disorders, Год журнала: 2023, Номер 335, С. 83 - 94

Опубликована: Май 6, 2023

Sleep and circadian disruption are associated with depression onset severity, but it is unclear which features (e.g., sleep duration, chronotype) important whether they can identify individuals showing poorer outcomes. Within a subset of the UK Biobank actigraphy mental health data (n = 64,353), penalised regression identified most useful 51 sleep/rest-activity predictors depression-related outcomes; including case-control (Major Depression (MD) vs. controls; postnatal controls) within-case comparisons (severe moderate MD; early later onset, atypical typical symptoms; comorbid anxiety; suicidality). Best models (of lasso, ridge, elastic net) were selected based on Area Under Curve (AUC). For MD controls (n(MD) 24,229; n(control) 40,124), lasso AUC was 0.68, 95 % confidence interval (CI) 0.67–0.69. Discrimination reasonable for symptoms (n(atypical) 958; n(typical) 18,722; ridge: 0.74, CI 0.71–0.77) poor remaining (AUCs 0.59–0.67). Key across included: difficulty getting up, insomnia symptoms, snoring, actigraphy-measured daytime inactivity lower morning activity (~8 am). In distinct 310,718), number these factors shown all Analyses cross-sectional in middle-/older aged adults: comparison longitudinal investigations younger cohorts necessary. measures alone provided to discrimination outcomes, several characteristics that may be clinically useful. Future work should assess alongside broader sociodemographic, lifestyle genetic features.

Язык: Английский

Mechanisms of blue light-induced eye hazard and protective measures: a review DOI Creative Commons
Xinli Ouyang, Jing Yang,

Zexin Hong

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2020, Номер 130, С. 110577 - 110577

Опубликована: Авг. 4, 2020

The risk of blue light exposure to human health has attracted increased research attention. Blue light, with relatively high energy, can cause irreversible photochemical damage eye tissue. Excessive the tends a series alterations, such as oxidative stress, mitochondrial apoptosis, inflammatory apoptosis and DNA damage, resulting in development dry disease, glaucoma, keratitis. Accordingly, physical protection, chemical pharmaceutical protective measures, gene therapy, other methods are widely used clinical treatment hazard. We reviewed studies on possible light-induced signaling pathways mechanisms summarized therapeutic approaches addressing

Язык: Английский

Процитировано

165
Sleeping when the world locks down: Correlates of sleep health during the COVID-19 pandemic across 59 countries DOI Creative Commons
Dilara Yüksel, Grace B. McKee, Paul B. Perrin

и другие.

Sleep Health, Год журнала: 2021, Номер 7(2), С. 134 - 142

Опубликована: Янв. 26, 2021

Язык: Английский

Процитировано

138
The influence of the environment and lifestyle on myopia DOI Creative Commons
Sayantan Biswas,

Antonio El Kareh,

Mariyem Qureshi

и другие.

Journal of PHYSIOLOGICAL ANTHROPOLOGY, Год журнала: 2024, Номер 43(1)

Опубликована: Янв. 31, 2024

Abstract Background Myopia, commonly known as near-sightedness, has emerged a global epidemic, impacting almost one in three individuals across the world. The increasing prevalence of myopia during early childhood heightened risk developing high and related sight-threatening eye conditions adulthood. This surge rates, occurring within relatively stable genetic framework, underscores profound influence environmental lifestyle factors on this condition. In comprehensive narrative review, we shed light both established potential contributors that affect development progression myopia. Main body Epidemiological interventional research consistently revealed compelling connection between increased outdoor time decreased children. protective effect may primarily be attributed to exposure characteristics natural (i.e., sunlight) release retinal dopamine. Conversely, irrespective time, excessive engagement near work can further worsen onset While exact mechanisms behind exacerbation are not fully comprehended, it appears involve shifts relative peripheral refraction, overstimulation accommodation, or complex interplay these factors, leading issues like image defocus, blur, chromatic aberration. Other spatial frequency visual environment, circadian rhythm, sleep, nutrition, smoking, socio-economic status, education have debatable independent influences development. Conclusion environment exerts significant Improving modifiable key predictors spent outdoors prevent slow intricate connections often obscure findings, making challenging disentangle their individual effects. complexity necessity for prospective studies employ objective assessments, such quantifying work, among others. These crucial gaining more understanding how various modified

Язык: Английский

Процитировано

70
Sleep Deprivation and Insomnia in Adolescence: Implications for Mental Health DOI Creative Commons
Sarà Uccella, Ramona Cordani, Federico Salfi

и другие.

Brain Sciences, Год журнала: 2023, Номер 13(4), С. 569 - 569

Опубликована: Март 28, 2023

Sleep changes significantly throughout the human lifespan. Physiological modifications in sleep regulation, common with many mammals (especially circadian rhythms), predispose adolescents to loss until early adulthood. Adolescents are one-sixth of all beings and at high risk for mental diseases (particularly mood disorders) self-injury. This has been attributed incredible number occurring a limited time window that encompasses rapid biological psychosocial modifications, which teens at-risk behaviors. Adolescents’ patterns have investigated as biunivocal cause potential damaging conditions, insufficient may be both consequence health problems. The recent COVID-19 pandemic particular made detrimental contribution adolescents’ quality. In this review, we aim summarize knowledge field explore implications (and future adults’) physical health, well outline strategies prevention.

Язык: Английский

Процитировано

54
Wearables in Chronomedicine and Interpretation of Circadian Health DOI Creative Commons
Denis Gubin,

Dietmar Weinert,

Oliver Stefani

и другие.

Diagnostics, Год журнала: 2025, Номер 15(3), С. 327 - 327

Опубликована: Янв. 30, 2025

Wearable devices have gained increasing attention for use in multifunctional applications related to health monitoring, particularly research of the circadian rhythms cognitive functions and metabolic processes. In this comprehensive review, we encompass how wearables can be used study disease. We highlight importance these as markers well-being potential predictors outcomes. focus on wearable technologies sleep research, medicine, chronomedicine beyond domain emphasize actigraphy a validated tool monitoring sleep, activity, light exposure. discuss various mathematical methods currently analyze actigraphic data, such parametric non-parametric approaches, linear, non-linear, neural network-based applied quantify non-circadian variability. also introduce novel actigraphy-derived markers, which personalized proxies status, assisting discriminating between disease, offering insights into neurobehavioral status. lifestyle factors physical activity exposure modulate brain health. establishing reference standards measures further refine data interpretation improve clinical The review calls existing tools methods, deepen our understanding health, develop healthcare strategies.

Язык: Английский

Процитировано

3
The Brain’s Reward System in Health and Disease DOI
Robert G. Lewis,

Ermanno Florio,

Daniela Punzo

и другие.

Advances in experimental medicine and biology, Год журнала: 2021, Номер unknown, С. 57 - 69

Опубликована: Янв. 1, 2021

Язык: Английский

Процитировано

94
The effects of seasons and weather on sleep patterns measured through longitudinal multimodal sensing DOI Creative Commons
Stephen M. Mattingly, Ted Grover, Gonzalo J. Martinez

и другие.

npj Digital Medicine, Год журнала: 2021, Номер 4(1)

Опубликована: Апрель 28, 2021

Abstract Previous studies of seasonal effects on sleep have yielded unclear results, likely due to methodological differences and limitations in data size and/or quality. We measured the habits 216 individuals across U.S. over four seasons for slightly a year using objective, continuous, unobtrusive measures local weather. In addition, we controlled demographics trait-like constructs previously identified correlate with behavior. investigated weather duration, bedtime, wake time. found several small but statistically significant patterns. observe strongest time especially during spring season: times are earlier, duration decreases (compared reference season winter). Sleep also modestly when day lengths get longer (between winter summer solstice). Bedtimes tend be later as outdoor temperature increases.

Язык: Английский

Процитировано

84
The circadian clock and metabolic homeostasis: entangled networks DOI Creative Commons
Leonardo Vinícius Monteiro de Assis, Henrik Oster

Cellular and Molecular Life Sciences, Год журнала: 2021, Номер 78(10), С. 4563 - 4587

Опубликована: Март 8, 2021

Abstract The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of time for the organism. synchrony between daily challenges imposed by environment needs to be aligned with biological processes and internal clock. In this review, is provided in-depth view molecular functioning clock, how system organized, central peripheral clocks communicate each other. sense, we provide overview neuro-hormonal factors controlled they affect tissues. We also evaluate signals released organs their effects other brain areas. Additionally, possible communication tissues novel layer organization reviewing recent studies literature. last section, analyze can modulate intracellular tissue-dependent metabolic organs. Taken altogether, goal review integrative function emphasis

Язык: Английский

Процитировано

68
Melatonergic Receptors (Mt1/Mt2) as a Potential Additional Target of Novel Drugs for Depression DOI Open Access
Dmytro I. Boiko, Anastasiia D. Shkodina, Mohammad Mehedi Hasan

и другие.

Neurochemical Research, Год журнала: 2022, Номер 47(10), С. 2909 - 2924

Опубликована: Июнь 11, 2022

Язык: Английский

Процитировано

48
A review of the current state of research on artificial blue light safety as it applies to digital devices DOI Creative Commons
Nikita Wong, Hamed Bahmani

Heliyon, Год журнала: 2022, Номер 8(8), С. e10282 - e10282

Опубликована: Авг. 1, 2022

Light is necessary for human health and well-being. As we spend more time indoors, are being increasingly exposed to artificial light. The development of lighting has allowed us control the brightness, colour, timing our light exposure. Yet, widespread use raised concerns about impact altering environment on health. adoption personal digital devices over past decade yet another source We a significant amount using with light-emitting screens, including smartphones tablets, at close range. emitted from these devices, while appearing white, an emission spectrum peak in blue Blue often characterised as hazardous its photon energy higher than that other wavelengths visible Under certain conditions, can cause harm retina ocular structures. also influence circadian rhythm processes mediated by melanopsin-expressing intrinsically photosensitive retinal ganglion cells. While component sunlight various physiological processes, whether low-illuminance presents risk remains ongoing area debate. technological advancements continue, it relevant understand how new may This review examines existing research safety eye, visual performance, functions.

Язык: Английский

Процитировано

45