Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat DOI Creative Commons
Haonan Li,

Yujiao Xiang,

Zemeng Zhu

и другие.

Journal of Neuroinflammation, Год журнала: 2021, Номер 18(1)

Опубликована: Ноя. 4, 2021

Chronic unpredictable mild stress (CUMS) can not only lead to depression-like behavior but also change the composition of gut microbiome. Regulating microbiome have an antidepressant effect, mechanism by which it improves depressive symptoms is clear. Short-chain fatty acids (SCFAs) are small molecular compounds produced fermentation non-digestible carbohydrates. SFCAs ubiquitous in intestinal endocrine and immune cells, making them important mediators microbiome-regulated body functions. The balance between pro- anti-inflammatory microglia plays role occurrence treatment depression caused chronic stress. Non-absorbable antibiotic rifaximin regulate structure We hypothesized that protects against stress-induced inflammation behaviors regulating abundance fecal microbial metabolites microglial functions.We administered 150 mg/kg intragastrically rats exposed CUMS for 4 weeks investigated microbiome, content short-chain serum brain, functional profiles hippocampal neurogenesis.Our results show ameliorated depressive-like induced CUMS, as reflected sucrose preference, open field test Morris water maze. Rifaximin increased relative Ruminococcaceae Lachnospiraceae, were significantly positively correlated with high level butyrate brain. factors released microglia, prevented neurogenic abnormalities CUMS.These suggest inflammatory function play a protective pubertal neurodevelopment during acids.

Язык: Английский

Prebiotics and Probiotics in Digestive Health DOI
Eamonn M.M. Quigley

Clinical Gastroenterology and Hepatology, Год журнала: 2018, Номер 17(2), С. 333 - 344

Опубликована: Сен. 27, 2018

Язык: Английский

Процитировано

306

Gut microbiota in neurodegenerative disorders DOI
Suparna Roy Sarkar, Sugato Banerjee

Journal of Neuroimmunology, Год журнала: 2019, Номер 328, С. 98 - 104

Опубликована: Янв. 9, 2019

Язык: Английский

Процитировано

273

Role of microbiota-derived short-chain fatty acids in nervous system disorders DOI Open Access
Rasoul Mirzaei, Behnaz Bouzari, Seyed Reza Hosseini‐Fard

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 139, С. 111661 - 111661

Опубликована: Май 8, 2021

During the past decade, accumulating evidence from research highlights suggested effects of bacterial communities human gut microbiota and their metabolites on health disease. In this regard, microbiota-derived receptors, beyond immune system, maintain metabolism homeostasis, which is essential to host's by balancing utilization intake nutrients. It has been shown that dysbiosis can cause pathology altered metabolites' formation, resulting in dysregulation system metabolism. The short-chain fatty acids (SCFAs), such as butyrate, acetate, succinate, are produced due fermentation process bacteria gut. noted remodeling associated with pathophysiology several neurological disorders, Alzheimer's disease, multiple sclerosis, Parkinson's amyotrophic lateral stress, anxiety, depression, autism, vascular dementia, schizophrenia, stroke, neuromyelitis optica spectrum among others. This review will discuss current most significant studies dealing some SCFAs microbial selected disorders.

Язык: Английский

Процитировано

268

Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases? DOI
Carolina Pellegrini, Luca Antonioli, Rocchina Colucci

и другие.

Acta Neuropathologica, Год журнала: 2018, Номер 136(3), С. 345 - 361

Опубликована: Май 24, 2018

Язык: Английский

Процитировано

234

Gut-Brain Psychology: Rethinking Psychology From the Microbiota–Gut–Brain Axis DOI Creative Commons
Shan Liang, Xiaoli Wu, Feng Jin

и другие.

Frontiers in Integrative Neuroscience, Год журнала: 2018, Номер 12

Опубликована: Сен. 11, 2018

Mental disorders and neurological diseases have brought rapidly increasing medical burdens. Although extensive researches been conducted hugely, effective therapies still progressing slowly. Current dilemma reminds us that the human is a superorganism. Only if we take self its partner microbiota into consideration at same time can better understand these diseases. Over last few centuries, has experienced tremendous changes much more than own genes because of modern transformations in diet, lifestyle, care, so on, paralleling epidemiological transition. Existing research indicates gut plays an important role this According to gut–brain psychology, crucial part gut–brain, it communicates with brain via microbiota–gut–brain axis. The almost develops synchronously brain, mind. Gut influences various normal mental processes phenomena they are involved pathophysiology numerous Targeting therapy for promising approach supported by three theories: hypothesis, "old friend" leaky theory. effects behavior fulfilled through microbiota-gut-brain axis which mainly composed nervous pathway, endocrine immune pathway. Undoubtedly, psychology will bring great enhancement neuroscience, psychiatry. Various improving methods including FMT, probiotics, prebiotics, healthy lifestyle shown capability promote function brain. Harnessing improve health, prevent related be true future.

Язык: Английский

Процитировано

234

The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology DOI
Tejaswini Doifode, Vijayasree V. Giridharan, Jaqueline S. Generoso

и другие.

Pharmacological Research, Год журнала: 2020, Номер 164, С. 105314 - 105314

Опубликована: Ноя. 25, 2020

Язык: Английский

Процитировано

233

The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame? DOI Open Access
Ashwinipriyadarshini Megur, Daiva Baltriukienė, Virginija Bukelskienė

и другие.

Nutrients, Год журнала: 2020, Номер 13(1), С. 37 - 37

Опубликована: Дек. 24, 2020

For years, it has been reported that Alzheimer’s disease (AD) is the most common cause of dementia. Various external and internal factors may contribute to early onset AD. This review highlights a contribution disturbances in microbiota–gut–brain (MGB) axis development Alteration gut microbiota composition determined by increase permeability barrier immune cell activation, leading impairment blood–brain function promotes neuroinflammation, neuronal loss, neural injury, ultimately Numerous studies have shown plays crucial role brain changes behavior individuals formation bacterial amyloids. Lipopolysaccharides amyloids synthesized can trigger cells residing activate response neuroinflammation. Growing experimental clinical data indicate prominent dysbiosis microbiota–host interactions Modulation with antibiotics or probiotic supplementation create new preventive therapeutic options Accumulating evidences affirm research on MGB involvement AD necessary for treatment targets therapies

Язык: Английский

Процитировано

227

Neurological manifestations of long-COVID syndrome: a narrative review DOI Creative Commons
Maria‐Ioanna Stefanou, Lina Palaiodimou, Eleni Bakola

и другие.

Therapeutic Advances in Chronic Disease, Год журнала: 2022, Номер 13

Опубликована: Янв. 1, 2022

Accumulating evidence points toward a very high prevalence of prolonged neurological symptoms among coronavirus disease 2019 (COVID-19) survivors. To date, there are no solidified criteria for 'long-COVID' diagnosis. Nevertheless, is conceptualized as multi-organ disorder with wide spectrum clinical manifestations that may be indicative underlying pulmonary, cardiovascular, endocrine, hematologic, renal, gastrointestinal, dermatologic, immunological, psychiatric, or disease. Involvement the central peripheral nervous system noted in more than one-third patients antecedent severe acute respiratory syndrome 2 (SARS-CoV-2) infection, while an approximately threefold higher incidence recorded observational studies including patient-reported data. The most frequent encompass fatigue; 'brain fog'; headache; cognitive impairment; sleep, mood, smell, taste disorders; myalgias; sensorimotor deficits; and dysautonomia. Although limited exists to date on pathophysiological mechanisms implicated manifestation 'long-COVID', neuroinflammatory oxidative stress processes thought prevail propagating sequelae. In this narrative review, we sought present comprehensive overview our current understanding features, risk factors, Moreover, propose diagnostic therapeutic algorithms aid prompt recognition management causes persist beyond resolution COVID-19. Furthermore, causal treatments currently unavailable, approaches symptom-oriented symptoms. addition, emphasize collaborative research initiatives urgently needed expedite development preventive strategies

Язык: Английский

Процитировано

222

Microbiota medicine: towards clinical revolution DOI Creative Commons
Prisca Gebrayel, Carole Nicco, Souhaila Al Khodor

и другие.

Journal of Translational Medicine, Год журнала: 2022, Номер 20(1)

Опубликована: Март 7, 2022

Abstract The human gastrointestinal tract is inhabited by the largest microbial community within body consisting of trillions microbes called gut microbiota. normal flora site many physiological functions such as enhancing host immunity, participating in nutrient absorption and protecting against pathogenic microorganisms. Numerous investigations showed a bidirectional interplay between microbiota organs intestines, lungs, brain, skin. Large evidence demonstrated, more than decade ago, that alteration key factor pathogenesis local systemic disorders. In this regard, deep understanding mechanisms involved symbiosis/dysbiosis crucial for clinical health field. We review most recent studies on involvement diseases. also elaborate different strategies used to manipulate prevention treatment future medicine strongly related quality our Targeting dysbiosis will be huge challenge.

Язык: Английский

Процитировано

195

Exploring Bacteroidetes: Metabolic key points and immunological tricks of our gut commensals DOI
Giulia Gibiino, Loris Riccardo Lopetuso, Franco Scaldaferri

и другие.

Digestive and Liver Disease, Год журнала: 2018, Номер 50(7), С. 635 - 639

Опубликована: Март 21, 2018

Язык: Английский

Процитировано

193