Journal of Neuroinflammation,
Год журнала:
2021,
Номер
18(1)
Опубликована: Ноя. 4, 2021
Chronic
unpredictable
mild
stress
(CUMS)
can
not
only
lead
to
depression-like
behavior
but
also
change
the
composition
of
gut
microbiome.
Regulating
microbiome
have
an
antidepressant
effect,
mechanism
by
which
it
improves
depressive
symptoms
is
clear.
Short-chain
fatty
acids
(SCFAs)
are
small
molecular
compounds
produced
fermentation
non-digestible
carbohydrates.
SFCAs
ubiquitous
in
intestinal
endocrine
and
immune
cells,
making
them
important
mediators
microbiome-regulated
body
functions.
The
balance
between
pro-
anti-inflammatory
microglia
plays
role
occurrence
treatment
depression
caused
chronic
stress.
Non-absorbable
antibiotic
rifaximin
regulate
structure
We
hypothesized
that
protects
against
stress-induced
inflammation
behaviors
regulating
abundance
fecal
microbial
metabolites
microglial
functions.We
administered
150
mg/kg
intragastrically
rats
exposed
CUMS
for
4
weeks
investigated
microbiome,
content
short-chain
serum
brain,
functional
profiles
hippocampal
neurogenesis.Our
results
show
ameliorated
depressive-like
induced
CUMS,
as
reflected
sucrose
preference,
open
field
test
Morris
water
maze.
Rifaximin
increased
relative
Ruminococcaceae
Lachnospiraceae,
were
significantly
positively
correlated
with
high
level
butyrate
brain.
factors
released
microglia,
prevented
neurogenic
abnormalities
CUMS.These
suggest
inflammatory
function
play
a
protective
pubertal
neurodevelopment
during
acids.
Biomedicine & Pharmacotherapy,
Год журнала:
2021,
Номер
139, С. 111661 - 111661
Опубликована: Май 8, 2021
During
the
past
decade,
accumulating
evidence
from
research
highlights
suggested
effects
of
bacterial
communities
human
gut
microbiota
and
their
metabolites
on
health
disease.
In
this
regard,
microbiota-derived
receptors,
beyond
immune
system,
maintain
metabolism
homeostasis,
which
is
essential
to
host's
by
balancing
utilization
intake
nutrients.
It
has
been
shown
that
dysbiosis
can
cause
pathology
altered
metabolites'
formation,
resulting
in
dysregulation
system
metabolism.
The
short-chain
fatty
acids
(SCFAs),
such
as
butyrate,
acetate,
succinate,
are
produced
due
fermentation
process
bacteria
gut.
noted
remodeling
associated
with
pathophysiology
several
neurological
disorders,
Alzheimer's
disease,
multiple
sclerosis,
Parkinson's
amyotrophic
lateral
stress,
anxiety,
depression,
autism,
vascular
dementia,
schizophrenia,
stroke,
neuromyelitis
optica
spectrum
among
others.
This
review
will
discuss
current
most
significant
studies
dealing
some
SCFAs
microbial
selected
disorders.
Frontiers in Integrative Neuroscience,
Год журнала:
2018,
Номер
12
Опубликована: Сен. 11, 2018
Mental
disorders
and
neurological
diseases
have
brought
rapidly
increasing
medical
burdens.
Although
extensive
researches
been
conducted
hugely,
effective
therapies
still
progressing
slowly.
Current
dilemma
reminds
us
that
the
human
is
a
superorganism.
Only
if
we
take
self
its
partner
microbiota
into
consideration
at
same
time
can
better
understand
these
diseases.
Over
last
few
centuries,
has
experienced
tremendous
changes
much
more
than
own
genes
because
of
modern
transformations
in
diet,
lifestyle,
care,
so
on,
paralleling
epidemiological
transition.
Existing
research
indicates
gut
plays
an
important
role
this
According
to
gut–brain
psychology,
crucial
part
gut–brain,
it
communicates
with
brain
via
microbiota–gut–brain
axis.
The
almost
develops
synchronously
brain,
mind.
Gut
influences
various
normal
mental
processes
phenomena
they
are
involved
pathophysiology
numerous
Targeting
therapy
for
promising
approach
supported
by
three
theories:
hypothesis,
"old
friend"
leaky
theory.
effects
behavior
fulfilled
through
microbiota-gut-brain
axis
which
mainly
composed
nervous
pathway,
endocrine
immune
pathway.
Undoubtedly,
psychology
will
bring
great
enhancement
neuroscience,
psychiatry.
Various
improving
methods
including
FMT,
probiotics,
prebiotics,
healthy
lifestyle
shown
capability
promote
function
brain.
Harnessing
improve
health,
prevent
related
be
true
future.
Nutrients,
Год журнала:
2020,
Номер
13(1), С. 37 - 37
Опубликована: Дек. 24, 2020
For
years,
it
has
been
reported
that
Alzheimer’s
disease
(AD)
is
the
most
common
cause
of
dementia.
Various
external
and
internal
factors
may
contribute
to
early
onset
AD.
This
review
highlights
a
contribution
disturbances
in
microbiota–gut–brain
(MGB)
axis
development
Alteration
gut
microbiota
composition
determined
by
increase
permeability
barrier
immune
cell
activation,
leading
impairment
blood–brain
function
promotes
neuroinflammation,
neuronal
loss,
neural
injury,
ultimately
Numerous
studies
have
shown
plays
crucial
role
brain
changes
behavior
individuals
formation
bacterial
amyloids.
Lipopolysaccharides
amyloids
synthesized
can
trigger
cells
residing
activate
response
neuroinflammation.
Growing
experimental
clinical
data
indicate
prominent
dysbiosis
microbiota–host
interactions
Modulation
with
antibiotics
or
probiotic
supplementation
create
new
preventive
therapeutic
options
Accumulating
evidences
affirm
research
on
MGB
involvement
AD
necessary
for
treatment
targets
therapies
Therapeutic Advances in Chronic Disease,
Год журнала:
2022,
Номер
13
Опубликована: Янв. 1, 2022
Accumulating
evidence
points
toward
a
very
high
prevalence
of
prolonged
neurological
symptoms
among
coronavirus
disease
2019
(COVID-19)
survivors.
To
date,
there
are
no
solidified
criteria
for
'long-COVID'
diagnosis.
Nevertheless,
is
conceptualized
as
multi-organ
disorder
with
wide
spectrum
clinical
manifestations
that
may
be
indicative
underlying
pulmonary,
cardiovascular,
endocrine,
hematologic,
renal,
gastrointestinal,
dermatologic,
immunological,
psychiatric,
or
disease.
Involvement
the
central
peripheral
nervous
system
noted
in
more
than
one-third
patients
antecedent
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
infection,
while
an
approximately
threefold
higher
incidence
recorded
observational
studies
including
patient-reported
data.
The
most
frequent
encompass
fatigue;
'brain
fog';
headache;
cognitive
impairment;
sleep,
mood,
smell,
taste
disorders;
myalgias;
sensorimotor
deficits;
and
dysautonomia.
Although
limited
exists
to
date
on
pathophysiological
mechanisms
implicated
manifestation
'long-COVID',
neuroinflammatory
oxidative
stress
processes
thought
prevail
propagating
sequelae.
In
this
narrative
review,
we
sought
present
comprehensive
overview
our
current
understanding
features,
risk
factors,
Moreover,
propose
diagnostic
therapeutic
algorithms
aid
prompt
recognition
management
causes
persist
beyond
resolution
COVID-19.
Furthermore,
causal
treatments
currently
unavailable,
approaches
symptom-oriented
symptoms.
addition,
emphasize
collaborative
research
initiatives
urgently
needed
expedite
development
preventive
strategies
Journal of Translational Medicine,
Год журнала:
2022,
Номер
20(1)
Опубликована: Март 7, 2022
Abstract
The
human
gastrointestinal
tract
is
inhabited
by
the
largest
microbial
community
within
body
consisting
of
trillions
microbes
called
gut
microbiota.
normal
flora
site
many
physiological
functions
such
as
enhancing
host
immunity,
participating
in
nutrient
absorption
and
protecting
against
pathogenic
microorganisms.
Numerous
investigations
showed
a
bidirectional
interplay
between
microbiota
organs
intestines,
lungs,
brain,
skin.
Large
evidence
demonstrated,
more
than
decade
ago,
that
alteration
key
factor
pathogenesis
local
systemic
disorders.
In
this
regard,
deep
understanding
mechanisms
involved
symbiosis/dysbiosis
crucial
for
clinical
health
field.
We
review
most
recent
studies
on
involvement
diseases.
also
elaborate
different
strategies
used
to
manipulate
prevention
treatment
future
medicine
strongly
related
quality
our
Targeting
dysbiosis
will
be
huge
challenge.
