International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(17), С. 9526 - 9526
Опубликована: Авг. 23, 2022
Biofilms
are
complex
structures
formed
by
bacteria,
fungi,
or
even
viruses
on
biotic
and
abiotic
surfaces,
they
can
be
found
in
almost
any
part
of
the
human
body.
The
prevalence
biofilm-associated
diseases
has
increased
recent
years,
mainly
because
frequent
use
indwelling
medical
devices
that
create
opportunities
for
clinically
important
bacteria
fungi
to
form
biofilms
either
device
neighboring
tissues.
As
a
result
their
resistance
antibiotics
host
immunity
factors,
have
been
associated
with
development
persistence
several
diseases.
inability
completely
eradicate
drastically
increases
burden
disease
both
patient
healthcare
system.
Therefore,
it
is
crucial
develop
innovative
ways
tackle
growth
biofilms.
This
review
focuses
dental-
implant-associated
biofilm
infections,
humans,
potential
therapeutic
intervention
strategies,
including
advances
pharmacology
biomedical
engineering.
It
lists
current
strategies
used
control
formation
biofilms,
novel
carriers,
antiseptics
disinfectants,
small
molecule
anti-biofilm
agents,
surface
treatment
nanostructure
functionalization,
as
well
multifunctional
coatings
particularly
suitable
providing
antibacterial
effects
implants,
treat
implant-related
bacterial
infections.
Materials,
Год журнала:
2022,
Номер
15(15), С. 5457 - 5457
Опубликована: Авг. 8, 2022
Additive
manufacturing
(AM,
also
known
as
3D
printing)
is
an
advanced
technique
that
has
enabled
progress
in
the
design
and
fabrication
of
customised
or
patient-specific
(meta-)biomaterials
biomedical
devices
(e.g.,
implants,
prosthetics,
orthotics)
with
complex
internal
microstructures
tuneable
properties.
In
past
few
decades,
several
guidelines
have
been
proposed
for
creating
porous
lattice
structures,
particularly
applications.
Meanwhile,
capabilities
AM
to
fabricate
a
wide
range
biomaterials,
including
metals
their
alloys,
polymers,
ceramics,
exploited,
offering
unprecedented
benefits
medical
professionals
patients
alike.
this
review
article,
we
provide
overview
principles
developed
used
biomaterials
well
those
dealing
three
major
categories
i.e.,
(and
alloys),
ceramics.
The
strategies
can
be
categorised
as:
library-based
design,
topology
optimisation,
bio-inspired
meta-biomaterials.
Recent
developments
related
applications
methods
aimed
at
enhancing
quality
final
3D-printed
improving
physical,
mechanical,
biological
characteristics
are
highlighted.
Finally,
examples
tuned
properties
functionalities
presented.
Materials,
Год журнала:
2022,
Номер
15(5), С. 1749 - 1749
Опубликована: Фев. 25, 2022
Ti
is
widely
used
as
a
material
for
orthopedic
implants.
As
rapid
and
effective
osseointegration
key
factor
the
successful
application
of
implants,
biologically
inert
materials
start
to
show
inherent
limitations,
such
poor
surface
cell
adhesion,
bioactivity,
bone-growth-inducing
capabilities.
Surface
modification
can
be
an
efficient
approach
addressing
biocompatibility,
mechanical,
functionality
issues
various
implant
materials.
In
this
study,
we
have
overviewed
more
than
140
papers
summarize
recent
progress
in
implants
by
physical
and/or
chemical
approaches,
aiming
at
optimizing
their
wear
resistance,
antimicrobial
properties.
advanced
manufacturing
technology
alloys,
additive
was
particularly
addressed
review.
We
also
provide
outlook
future
research
directions
field
contribution
development
biomedical
applications.
Smart Materials in Manufacturing,
Год журнала:
2022,
Номер
1, С. 100001 - 100001
Опубликована: Май 30, 2022
Bacterial
infection
is
one
of
the
most
common
complications
following
implantation
biomaterials
and
can
lead
to
aseptic
loosening,
prosthesis
failure,
even
morbidity
or
mortality.
Some
physicochemical
surface
properties
metallic
implants
such
as
topography,
roughness,
pore
size,
degree
porosity,
play
key
roles
in
bone
formation.
However,
highly
porous
roughened
surfaces
result
weaker
mechanical
more
bacterial
adhesion.
Due
existing
removing
biofilms,
attention
needed
produce
and/or
rough
additively
manufactured
materials
that
exhibit
high
biocompatibility
antimicrobial
efficacy.
The
generated
by
additive
manufacturing
technologies
require
researchers
discover
methods
for
biofilm
removal
via
incorporation
additional
biofunctionalities
reduce
rate
colonization
implants.
Furthermore,
complex
3D-printed
structures
fabricated
possess
larger
areas
thus
are
susceptible
infection.
This
necessitates
development
non-pharmacological
techniques
danger
colonization.
current
review
provides
insight
into
formation
pathogens
on
discusses
active
antipathogenic
modifications
inhibit
control
•
adhesion
3D
printed
biomaterials.
Active
coatings
prevent
Important
role
printing
parameters
strategies
successful
implantation.
Polymers,
Год журнала:
2022,
Номер
14(10), С. 2117 - 2117
Опубликована: Май 23, 2022
With
the
ability
to
fabricate
complex
structures
while
meeting
individual
needs,
additive
manufacturing
(AM)
offers
unprecedented
opportunities
for
bone
tissue
engineering
in
biomedical
field.
However,
traditional
metal
implants
have
many
adverse
effects
due
their
poor
integration
with
host
tissues,
and
therefore
new
material
porous
are
gradually
being
developed
that
suitable
clinical
medical
applications.
From
perspectives
of
technology
materials,
this
article
discusses
a
process
ideal
materials
biological
engineering.
It
begins
review
methods
applicable
existing
technologies
applications
biomedicine,
introducing
advantages
disadvantages
various
AM
technologies.
The
properties
including
metals
polymers,
commonly
used
technologies,
recent
developments,
discussed
detail
summarized.
In
addition,
main
challenges
different
metallic
polymer
such
as
biodegradability,
anisotropy,
growth
factors
promote
osteogenic
capacity,
enhancement
mechanical
also
introduced.
Finally,
development
prospects
biomaterials
considered.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(26)
Опубликована: Июнь 10, 2023
Bacterial
infection
caused
by
biomaterials
is
a
very
serious
problem
in
the
clinical
treatment
of
implants.
The
emergence
antibiotic
resistance
has
prompted
other
antibacterial
agents
to
replace
traditional
antibiotics.
Silver
rapidly
developing
as
an
candidate
material
inhibit
bone
infections
due
its
significant
advantages
such
high
timeliness,
efficiency,
and
less
susceptibility
bacterial
resistance.
However,
silver
strong
cytotoxicity,
which
can
cause
inflammatory
reactions
oxidative
stress,
thereby
destroying
tissue
regeneration,
making
application
silver-containing
extremely
challenging.
In
this
paper,
reviewed,
focusing
on
following
three
issues:
1)
how
ensure
excellent
properties
silver,
not
easy
resistance;
2)
choose
appropriate
method
combine
with
biomaterials;
3)
make
hard
implants
have
further
research.
Following
brief
introduction,
discussion
focuses
biomaterials,
emphasis
effects
physicochemical
properties,
structural
biological
biomaterials.
Finally,
review
concludes
authors'
perspectives
challenges
future
directions
commercialization
in-depth
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(1)
Опубликована: Авг. 3, 2023
The
need
for
sustainable
development
has
never
been
more
urgent,
as
the
world
continues
to
struggle
with
environmental
challenges,
such
climate
change,
pollution,
and
dwindling
natural
resources.
use
of
renewable
recycled
waste
materials
a
source
raw
biomaterials
tissue
engineering
is
promising
avenue
development.
Although
rapidly
developed,
challenges
associated
fulfilling
increasing
demand
bone
substitutes
implants
remain
unresolved,
particularly
global
population
ages.
This
review
provides
an
overview
materials,
eggshells,
seashells,
fish
residues,
agricultural
biomass,
that
can
be
transformed
into
engineering.
While
metals
in
its
early
stages,
probiotics
polymers
improve
biofunctionalities
highlighted.
Despite
advances
additive
manufacturing
(AM),
studies
on
AM
waste-derived
bone-substitutes
are
limited.
It
foreseeable
technologies
provide
alternative
implants.
preliminary
results
eggshell
seashell-derived
calcium
phosphate
rice
husk
ash-derived
silica
likely
pave
way
advanced
applications
sustainably
addressing
several
unmet
clinical
applications.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Ноя. 7, 2023
Titanium
(Ti)
and
its
alloys
have
good
biocompatibility,
mechanical
properties
corrosion
resistance,
making
them
attractive
for
biomedical
applications.
However,
their
biological
inertness
lack
of
antimicrobial
may
compromise
the
success
implants.
In
this
review,
potential
micro-arc
oxidation
(MAO)
technology
to
create
bioactive
coatings
on
Ti
implants
is
discussed.
The
review
covers
following
aspects:
1)
different
factors,
such
as
electrolyte,
voltage
current,
affect
MAO
coatings;
2)
including
cytocompatibility,
hemocompatibility,
angiogenic
activity,
osteogenic
activity
osseointegration;
3)
antibacterial
can
be
achieved
by
adding
copper
(Cu),
silver
(Ag),
zinc
(Zn)
other
elements
achieve
properties;
4)
combined
with
physical
chemical
techniques
enhance
performance
coatings.
It
concluded
that
offer
new
opportunities
improving
use
in
applications,
some
suggestions
future
research
are
provided.
Abstract
Dental
and
orthopedic
titanium
implants
are
successfully
widely
used
but
still
face
challenges
due
to
complications
leading
high
treatment
cost,
morbidity,
even
mortality.
This
review
focuses
on
the
hybrid
coatings
designed
prevent
mitigate
implant
failure
by
integrating
multiple
strategies
materials.
The
forms
of
manufacturing
synthesizing
were
first
discussed.
We
then
categorize
these
based
their
biological
functions:
antibacterial
coatings,
which
essential
for
preventing
difficult‐to‐treat
infection;
promote
osseointegration,
crucial
mechanical
stability
implants;
that
encourage
soft
tissue
attachment,
contributing
overall
success
esthetics
implant.
summarize
state
art
in
multifunctional
integrate
functions
as
an
alternative,
holistic
approach
reducing
complications.
culminates
a
discussion
future
directions
field,
emphasizing
potential
notable
biofunctional
toward
obtaining
commercial
patients.
Together,
our
article
provides
comprehensive
overview
current
developments
glimpse
into
potentially
revolutionizing
dental
implants.
