A self-healing injectable hydrogel integrated with enzymatic and nonenzymatic antioxidants as artificial antioxidant defense system for diabetic wound healing DOI Creative Commons
Ye Wang, Chong Chen, Changyuan He

et al.

Materials & Design, Journal Year: 2023, Volume and Issue: 237, P. 112620 - 112620

Published: Dec. 30, 2023

Chronic diabetic wounds seriously threaten human health due to their intractable nature in a complex pathological microenvironment that contains oxidative stress, persistent inflammatory status, hypoxia and bacterial infections, of which damage contributing the most. Applied materials can mimic natural intracellular antioxidant defense system are perceived have huge therapeutic potential. Herein, we present novel strategy prepare versatile nanocomposite hydrogel by incorporating nanoenzyme (manganese dioxide (MnO2)) nonenzymatic components (polydopamine (PDA)) dynamic network composed thioctic acid tannic (TA). The prepared exhibited outstanding adhesive injectable properties, making it adapt perfectly with different shapes depths. More importantly, encapsulation PDA@MnO2 nanoparticles (NPs) conferred superior performance effectively scavenge multiple types reactive nitrogen oxygen species (RNOS) reduce response regulating macrophage polarization. Meanwhile, showed high-performance catalyzing ability transfer hydrogen peroxide (H2O2) into (O2), could further alleviate hypoxic wound environment. Moreover, excellent near-infrared (NIR) photothermal antibacterial effect. Collectively, our findings indicate synthesized shows potential for use clinical setting treat wounds.

Language: Английский

Photothermal antibacterial materials to promote wound healing DOI

Luning He,

Donghua Di,

Xinhui Chu

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 363, P. 180 - 200

Published: Sept. 27, 2023

Language: Английский

Citations

129
Bioinspired polydopamine hydrogels: Strategies and applications DOI
Yuanting Xu, Junfei Hu, Jingjing Hu

et al.

Progress in Polymer Science, Journal Year: 2023, Volume and Issue: 146, P. 101740 - 101740

Published: Sept. 17, 2023

Language: Английский

Citations

110
An injectable, self-healing, and antioxidant collagen- and hyaluronic acid-based hydrogel mediated with gallic acid and dopamine for wound repair DOI
Changkai Yang, Yuanzhi Zhang, Xiaoxia Zhang

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 320, P. 121231 - 121231

Published: July 27, 2023

Language: Английский

Citations

73
Injectable multifunctional chitosan/dextran-based hydrogel accelerates wound healing in combined radiation and burn injury DOI

Jintao Shen,

Wencheng Jiao,

Ziyuan Chen

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 316, P. 121024 - 121024

Published: May 18, 2023

Language: Английский

Citations

55
Novel Natural Polymer‐Based Hydrogel Patches with Janus Asymmetric‐Adhesion for Emergency Hemostasis and Wound Healing DOI
Lanfang Sun,

Junyi Zhou,

Jieying Lai

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)

Published: April 27, 2024

Abstract An asymmetrical wound dressing functions akin to human skin by serving as a protective barrier between and its immediate environment. However, significant challenges persist concerning the robust adhesion properties of hydrogels, particularly when applied in emergency hemostasis healing contexts. Herein, study has successfully synthesized hydrogel patches with Janus asymmetric‐adhesion, denoted HGO‐C, exclusively comprised natural polymers. This achievement is realized through assembly adhesive (HGO) non‐adhesive (CGC), thereby amalgamating their distinct functionalities. The component served physical shield safeguarding against contamination, while hydrogel, contacted surface, firmly adhered it, swiftly arresting bleeding facilitating healing. Cytocompatibility tests, hemolysis antibacterial assays, coagulation assays demonstrated excellent biocompatibility, antibacterial, hemostatic HGO‐C. Finally, vivo experiments, including liver hemorrhage assay assay, unequivocally showed rapid enhanced capabilities Consequently, these distinctive patches, derived from polymers characterized asymmetric properties, may have great potential for real‐life usage clinical patients.

Language: Английский

Citations

38
Stimuli‐Responsive Hydrogels for Antibacterial Applications DOI
Zhe Hao, Xiyan Li, Ruizhong Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 9, 2024

Hydrogels have emerged as promising candidates for biomedical applications, especially in the field of antibacterial therapeutics, due to their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration stimuli-responsive functions into hydrogels holds potential enhance properties therapeutic efficacy, dynamically responding different external or internal stimuli, such pH, temperature, enzymes, light. Therefore, this review describes applications hydrogel dressings responsive stimuli therapy. collaborative interaction between materials is discussed. This synergistic approach, contrast conventional materials, not only amplifies effect but also alleviates adverse side effects diminishes incidence multiple infections drug resistance. provides a comprehensive overview current challenges outlines future research directions hydrogels. It underscores imperative ongoing interdisciplinary aimed at unraveling mechanisms wound healing. understanding crucial optimizing design implementation Ultimately, aims offer scientific guidance development practical clinical application dressings.

Language: Английский

Citations

26
Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions DOI
Yuancai Lv,

Fengying Cai,

Xingkai Zhao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(21)

Published: Jan. 28, 2024

Abstract Abdominal and intrauterine adhesions are common postoperative problems that can cause serious complications. Current adhesives usually double sided suffer from poor wet adhesion, nondegradability, monofunctionality, which limits their application in preventing adhesions. Herein, a bioinspired microstructured Janus bioadhesive, named OD/GM@PG, with adhesive inner layer an antiadhesive outer is prepared by combining electrostatic spun materials. By using both capillary suction catechol‐based strategy, the strength interfacial toughness of bioadhesive reach 98 kPa 325 J m −2 , respectively, much higher than those commercial fibrin glues cyanoacrylate glues. The acts as physical barrier friction‐reducing effects. Additionally, demonstrates biodegradable, hemostatic, antioxidative, anti‐inflammatory, prohealing properties. In vivo results show asymmetric adhesion effect effectively abdominal Notably, tandem mass tags‐labeled quantitative proteomics analysis demonstrate expression inflammatory response‐associated proteins (S100A8, S100A9) associated adhesion; significantly downregulates this expression. Therefore, OD/GM@PG promising candidate for

Language: Английский

Citations

23
Hydroxypropyl chitosan/ε-poly-l-lysine based injectable and self-healing hydrogels with antimicrobial and hemostatic activity for wound repair DOI
Shuting Peng, Sen Niu, Qin Gao

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 337, P. 122135 - 122135

Published: April 7, 2024

Language: Английский

Citations

18
Hemostasis Strategies and Recent Advances in Hydrogels for Managing Uncontrolled Hemorrhage DOI

Lijun Liu,

Rui Jing, Lei Yao

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Hemorrhage continues to pose a significant challenge in various medical contexts, underscoring the need for advanced hemostatic materials. Hemostatic hydrogels have gained recognition as innovative tools addressing uncontrollable bleeding, attributed their distinctive features including biological compatibility, tunable mechanical properties, and exceptional performance. This review provides comprehensive overview of that offer rapid effective bleeding control. Particularly, this focuses on hydrogel design associated mechanisms. Additionally, recent advancements application these materials are discussed detail, especially clinical trials. Finally, challenges potential analyzed assessed. seeks emphasize role biomedical applications hemorrhage control provide perspectives innovation clinically applicable

Language: Английский

Citations

2
Bioadhesives with Antimicrobial Properties DOI Creative Commons
Mustafa Nakipoğlu, Ayşen Tezcaner, Christopher H. Contag

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(49)

Published: June 3, 2023

Bioadhesives with antimicrobial properties enable easier and safer treatment of wounds as compared to the traditional methods such suturing stapling. Composed natural or synthetic polymers, these bioadhesives seal facilitate healing while preventing infections through activity locally released drugs, nanocomponents, inherently polers. Although many different materials strategies are employed develop bioadhesives, design biomaterials necessitates a prudent approach achieving all required including optimal adhesive cohesive properties, biocompatibility, can be challenging. Designing tunable physical, chemical, biological will shed light on path for future advancement properties. In this review, requirements commonly used developing discussed. particular, their synthesis experimental clinical applications variety organs reviewed. Advances in pave way better management increase positive outcomes.

Language: Английский

Citations

41