touchREVIEWS in Neurology, Год журнала: 2020, Номер 16(1), С. 25 - 25
Опубликована: Янв. 1, 2020
Язык: Английский
Nature Reviews Drug Discovery, Год журнала: 2023, Номер 22(5), С. 387 - 409
Опубликована: Март 27, 2023
Poor medication adherence is a pervasive issue with considerable health and socioeconomic consequences. Although the underlying reasons are generally understood, traditional intervention strategies rooted in patient-centric education empowerment have proved to be prohibitively complex and/or ineffective. Formulating pharmaceutical drug delivery system (DDS) promising alternative that can directly mitigate many common impediments adherence, including frequent dosing, adverse effects delayed onset of action. Existing DDSs already positively influenced patient acceptability improved rates across various disease types. The next generation systems potential instate an even more radical paradigm shift by, for example, permitting oral biomacromolecules, allowing autonomous dose regulation enabling several doses mimicked single administration. Their success, however, contingent on their ability address problems made unsuccessful past. Improving recognized as one most impactful cost-effective improving general population. Here, Baryakova colleagues assess next-generation discuss impact had different
Язык: Английский
Процитировано
182
International Journal of Pharmaceutics, Год журнала: 2021, Номер 604, С. 120759 - 120759
Опубликована: Июнь 4, 2021
Язык: Английский
Процитировано
89
Food Hydrocolloids, Год журнала: 2023, Номер 141, С. 108684 - 108684
Опубликована: Март 14, 2023
Язык: Английский
Процитировано
25
Therapeutic Delivery, Год журнала: 2025, Номер unknown, С. 1 - 14
Опубликована: Янв. 12, 2025
Orodispersible film (ODF) is one of the novel formulations that disintegrate rapidly in mouth without requisite for water compared to other conventional oral solid dosage formulations. This delivery system serves as a convenient mode administration, especially patients who have dysphagia and fluid restriction, being beneficial pediatric, geriatric, bedridden patients. A sildenafil ODF containing citrate formulated be used with erectile dysfunction (ED). review discusses advantages improving compliance satisfaction these describes manufacturing techniques, evaluation tests, bioequivalence, stability studies ODF. formulation offers unique benefit ED by their acceptance respecting privacy need discreet treatment. Moreover, comparison pharmacokinetic parameters between administered film-coated tablet were similar. It also demonstrated reliable performance yielded consistent product, meeting all specifications at release after three weeks storage under stressed conditions (60°C). Sildenafil warrants improved ease intake, taste, portability, storage, among patients, making it potential most preferred drug choice.
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2023, Номер 15(2), С. 361 - 361
Опубликована: Янв. 20, 2023
Orodispersible Films (ODFs) are drug delivery systems manufactured with a wide range of methods on big scale or for customized medicines and small-scale pharmacy. Both ODFs their fabrication have certain limitations. Many pharmaceutical companies academic research centers across the world cooperate in order to cope these issues also find new formulations array APIs what could make work profitable them beneficial patients as well. The number pending patent applications granted patents innovative approaches makes progress manufacturing unquestionable. commercially available is still growing. However, some were discontinued no longer markets. This review aims summarize currently marketed those withdrawn from sale provides an insight into recently published studies concerning orodispersible films, emphasizing utilized APIs. highlights attempts scientific communities overcome ODF’s
Язык: Английский
Процитировано
18
British Journal of Clinical Pharmacology, Год журнала: 2022, Номер 88(12), С. 5128 - 5148
Опубликована: Июль 18, 2022
Solid oral dosage forms (SODFs) (often called pills by patients) are the default formulation to treat medical ailments. Beneficial therapeutic outcomes rely on patients taking them as directed. Up 40% of population experience difficulties swallowing SODFs, resulting in reduced adherence and impaired efficacy. Often associated with children, this also presents adults dysphagia, without any organic dysphagia (non-physiological-related or functional dysphagia). This review aims identify appraise current interventions used screen for overcome pill aversion dysphagia. A comprehensive search literature was conducted. Articles reporting aged ≥18 years no underlying cause, history of, existing were included. Study quality determined using STROBE tool observational studies. narrative synthesis findings prepared. We identified 18 relevant cohort studies, which demonstrate that is a global problem. Perceived ease and/or SODF swallowability appears be influenced female gender, younger age, co-morbidities (e.g., depression), physical properties. Patients often modify their medicines rather than raise issue healthcare team. Screening haphazard but controlled postural adjustments, coating SODFs behavioural appear successful solutions. barrier effective medication use. Healthcare professionals must recognise problem requiring identification through screening resolution training interventions, appropriate selection specialist referral.
Язык: Английский
Процитировано
27
Parkinsonism & Related Disorders, Год журнала: 2019, Номер 62, С. 51 - 56
Опубликована: Фев. 4, 2019
Язык: Английский
Процитировано
37
Pharmaceutics, Год журнала: 2020, Номер 13(1), С. 32 - 32
Опубликована: Дек. 28, 2020
Oral drug administration provided as solid oral dosage forms (SODF) remains the major route of therapy in primary and secondary care. There is clear evidence for a growing number clinically relevant swallowing issues (e.g., dysphagia) older patient population, especially when considering multimorbid, frail, polymedicated patients. Swallowing impairments have negative impact on SODF administration, which leads to poor adherence inappropriate alterations crushing, splitting). Different strategies been proposed over years order enhance experience with SODF, by using conventional techniques or applying aids devices. Nevertheless, new formulation designs must be considered implementing centric approach efficiently improve populations. Together appropriate size reductions, innovative film coating materials that can applied provide safety efficacy little effort being required patients are still needed. With mind, literature review was conducted identify availability claiming shorten esophageal transit times overall The majority technologies were identified patent applications, they mainly included well-known water soluble polymers commonly into pharmaceutical coatings. scientific demonstrating benefits given concerned populations very limited. Consequently, safe, effective, proven solutions address increasing prevalence population
Язык: Английский
Процитировано
33
International Journal of Pharmaceutics, Год журнала: 2025, Номер 670, С. 125194 - 125194
Опубликована: Янв. 10, 2025
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106691 - 106691
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0