SARS-CoV-2 Omicron variant: recent progress and future perspectives

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Апрель 28, 2022

Abstract Since the outbreak of coronavirus disease 2019 (COVID-19) pandemic, there have been a few variants severe acute respiratory syndrome 2 (SARS-CoV-2), one which is Omicron variant (B.1.1.529). The most mutated SARS-CoV-2 variant, and its high transmissibility immune evasion ability raised global concerns. Owing to enhanced transmissibility, has rapidly replaced Delta as dominant in several regions. However, recent studies shown that exhibits reduced pathogenicity due altered cell tropism. In addition, significant resistance neutralizing activity vaccines, convalescent serum, antibody therapies. present review, advances molecular clinical characteristics infectivity, pathogenicity, was summarized, potential therapeutic applications response infection were discussed. Furthermore, we highlighted future waves strategies end pandemic.

Язык: Английский

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A Detailed Overview of SARS-CoV-2 Omicron: Its Sub-Variants, Mutations and Pathophysiology, Clinical Characteristics, Immunological Landscape, Immune Escape, and Therapies

Viruses, Год журнала: 2023, Номер 15(1), С. 167 - 167

Опубликована: Янв. 5, 2023

The COVID-19 pandemic has created significant concern for everyone. Recent data from many worldwide reports suggest that most infections are caused by the Omicron variant and its sub-lineages, dominating all previously emerged variants. numerous mutations in Omicron’s viral genome sub-lineages attribute it a larger amount of fitness, owing to alteration transmission pathophysiology virus. With rapid change structure, sub-variants, namely BA.1, BA.2, BA.3, BA.4, BA.5, dominate community with an ability escape neutralization efficiency induced prior vaccination or infections. Similarly, several recombinant sub-variants Omicron, XBB, XBD, XBF, etc., have emerged, which better understanding. This review mainly entails changes due having higher number mutations. binding affinity, cellular entry, disease severity, infection rates, importantly, immune evading potential them discussed this review. A comparative analysis Delta other variants evolved before gives readers in-depth understanding landscape infection. Furthermore, discusses range abilities possessed approved antiviral therapeutic molecules neutralizing antibodies functional against sub-variants. evolution is causing infections, but broader aspect their not been explored. Thus, scientific should adopt elucidative approach obtain clear idea about recently including variants, so effective vaccines drugs can be achieved. This, turn, will lead drop cases and, finally, end pandemic.

Язык: Английский

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SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort Study of 23 Million Residents

JAMA Cardiology, Год журнала: 2022, Номер 7(6), С. 600 - 600

Опубликована: Апрель 20, 2022

Reports of myocarditis after SARS-CoV-2 messenger RNA (mRNA) vaccination have emerged.

Язык: Английский

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Proportion of asymptomatic infection and nonsevere disease caused by SARS‐CoV‐2 Omicron variant: A systematic review and analysis

Journal of Medical Virology, Год журнала: 2022, Номер 94(12), С. 5790 - 5801

Опубликована: Авг. 13, 2022

SARS-CoV-2 Omicron variant seemed to cause milder disease compared previous predominated variants. We aimed conduct a meta-analysis assess the pooled proportion of nonsevere and asymptomatic infection among COVID-19 patients infected with Delta. searched PubMed, Embase, Web Science, China National Knowledge Infrastructure (CNKI) databases. included studies from November 1, 2021, April 18, 2022, Delta October 2020, June 30, 2022. Studies without corresponding data, less than 50 patients, or obviously biased concerning main outcome were excluded. Meta-analysis was performed in R 4.2.0 "meta" package. Subgroup analyses conducted by study group vaccination status. The 25.5% (95% confidence interval [CI] 17.0%-38.2%) 97.9% CI 97.1%-98.7%), significantly higher those 8.4% 4.4%-16.2%) 91.4% 87.0%-96.0%). During wave, children adolescents had infection, SOTR elderly lower disease, booster dose contributed both disease. This estimates caused other predominant result has important implications for future policy making.

Язык: Английский

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The Importance of Vaccination in the Context of the COVID-19 Pandemic: A Brief Update Regarding the Use of Vaccines

Vaccines, Год журнала: 2022, Номер 10(4), С. 591 - 591

Опубликована: Апрель 12, 2022

The COVID-19 pandemic has led the world to undertake largest vaccination campaign in human history. In record time, unprecedented scientific and governmental efforts have resulted acquisition of immunizers utilizing different technologies (nucleotide acids, viral vectors, inactivated protein-based vaccines). Currently, 33 vaccines already been approved by regulatory agencies countries, more than 10 billion doses administered worldwide. Despite undeniable impact on control pandemic, recurrent emergence new variants interest raised challenges. recent mutations precede outbreaks that rapidly spread at global proportions. addition, reducing protective efficacy rates observed among main authorized vaccines. Besides these issues, several other crucial issues for appropriate combatting remain uncertain or under investigation. Particularly noteworthy include use vaccine-boosting strategies increase protection; concerns related long-term safety vaccines, child immunization reliability uncommon adverse events; persistence virus society; transition from a an endemic state. this review, we describe updated scenario regarding SARS-CoV-2 outline current discussions covering vaccine efficacy, future perspectives.

Язык: Английский

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COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy

Translational research, Год журнала: 2022, Номер 251, С. 84 - 95

Опубликована: Авг. 12, 2022

Язык: Английский

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Pathogenesis and Mechanisms of SARS-CoV-2 Infection in the Intestine, Liver, and Pancreas

Cells, Год журнала: 2023, Номер 12(2), С. 262 - 262

Опубликована: Янв. 9, 2023

The novel coronavirus, SARS-CoV-2, rapidly spread worldwide, causing an ongoing global pandemic. While the respiratory system is most common site of infection, a significant number reported cases indicate gastrointestinal (GI) involvement. GI symptoms include anorexia, abdominal pain, nausea, vomiting, and diarrhea. Although mechanisms pathogenesis are still being examined, viral components isolated from stool samples infected patients suggest potential fecal–oral transmission route. In addition, RNA has been detected in blood patients, making hematologic dissemination virus proposed route for Angiotensin-converting enzyme 2 (ACE2) receptors serve as cellular entry mechanism virus, these particularly abundant throughout tract, intestine, liver, pancreas extrapulmonary sites infection reservoirs developing mutations new variants that contribute to uncontrolled disease resistance treatments. This dysregulation immune play role profound inflammatory coagulative cascades increased severity risk death several COVID-19 patients. article reviews various gastrointestinal, pancreatic injury.

Язык: Английский

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Early combination therapy of COVID-19 in high-risk patients

Infection, Год журнала: 2023, Номер 52(3), С. 877 - 889

Опубликована: Ноя. 29, 2023

Prolonged shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed in immunocompromised hosts. Early monotherapy with direct-acting antivirals or monoclonal antibodies, as recommended by the international guidelines, does not prevent this certainty. Dual therapies may therefore have a synergistic effect.

Язык: Английский

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Cardiovascular effects of the post-COVID-19 condition

Nature Cardiovascular Research, Год журнала: 2024, Номер 3(2), С. 118 - 129

Опубликована: Янв. 18, 2024

Язык: Английский

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Research Progress of Bioactive Components in Sanghuangporus spp.

Molecules, Год журнала: 2024, Номер 29(6), С. 1195 - 1195

Опубликована: Март 7, 2024

The species in Sanghuangporus are a group of edible mushrooms with long history oral use East Asia as health-improvement method. They should be classified under the genus rather than mistakenly Phellinus or Inonotus. major components this consist polysaccharides, polyphenols, triterpenoids, and flavonoids, all which exist fruiting bodies mycelia. For extraction, studies have shown methods using hot water, ethanol, DES solvent, alkaline, followed by purification including traditional anion column, Sevag solution, macroporous resin, magnetic polymers. Proven modern medical technology, these possess promising anti-inflammatory, antioxidative, antitumor, immunoregulation effects; additionally, they health-improving effects pulmonary protection, hypoglycemic properties, sleep improvement, gout mitigation, antiaging, neuroprotection, muscle-strengthening abilities. Several toxicity revealed their safety recommend dose 1 g/kg for mice. As newly emerged concept, functional food can provide not only life-sustaining nutrients but also some effects. In conclusion, we substantiate Sanghuang comprehensively presenting information on extraction methods, component structural nontoxicity, hoping to benefit development food.

Язык: Английский

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