Arabian Journal of Chemistry,
Год журнала:
2024,
Номер
17(10), С. 105968 - 105968
Опубликована: Авг. 17, 2024
Hydrogels
are
three-dimensional
structures
that
serve
as
substitutes
for
the
extracellular
matrix
(ECM)
and
possess
outstanding
physicochemical
biochemical
characteristics.
They
gaining
importance
in
regenerative
medicine
because
of
their
similarity
to
natural
terms
moisture
content
wound
tissue
healing
permeability.
Tissue
engineering
advancements
have
resulted
development
flexible
hydrogels
mimic
dynamic
characteristics
ECM.
Several
approaches
been
applied
produce
from
biopolymers
with
enhanced
functional
structural
different
applications
(TERM).
This
review
provides
a
comprehensive
overview
hydrogel
healing,
engineering,
drug
delivery
systems.
We
outline
types
based
on
physical
chemical
crosslinking,
fundamental
properties,
TERM.
article
provided
recent
literature
within
five
years.
Recent
developments
biopolymer-based
state-of-the-art
discussed,
emphasizing
significant
challenges
future
perspectives.
Advanced Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 11, 2023
Bioprinting
has
attracted
much
attention
due
to
its
suitability
for
fabricating
biomedical
devices.
In
particular,
bioprinting
become
one
of
the
growing
centers
in
field
wound
healing,
with
various
types
bioprinted
devices
being
developed,
including
3D
scaffolds,
microneedle
patches,
and
flexible
electronics.
Bioprinted
can
be
designed
specific
biostructures
biofunctions
that
closely
match
shape
sites
accelerate
regeneration
skin
through
approaches.
Herein,
a
comprehensive
review
smart
dressings
is
presented,
emphasizing
crucial
effect
determining
biofunctions.
The
begins
an
overview
techniques
devices,
followed
in-depth
discussion
polymer-based
inks,
modification
strategies,
additive
ingredients,
properties,
applications.
strategies
are
divided
into
seven
categories,
chemical
synthesis
novel
physical
blending,
coaxial
bioprinting,
multimaterial
absorption,
immobilization,
hybridization
living
cells,
examples
presented.
Thereafter,
frontiers
4D
artificial
intelligence-assisted
situ
discussed
from
perspective
interdisciplinary
sciences.
Finally,
current
challenges
future
prospects
this
highlighted.
Microneedles
(MNs)
can
be
used
for
the
topical
treatment
of
skin
disorders
as
they
directly
deliver
therapeutics
to
site
lesions,
resulting
in
increased
therapeutic
efficacy
while
having
minimum
side
effects.
MNs
are
different
kinds
(e.g.,
small
molecules,
macromolecules,
nanomedicines,
living
cells,
bacteria,
and
exosomes)
treating
various
disorders,
including
superficial
tumors,
wounds,
infections,
inflammatory
diseases,
abnormal
appearance.
The
improved
by
integrating
advantages
multiple
perform
combination
therapy.
Through
careful
designing,
further
modified
with
biomimetic
structures
responsive
drug
release
from
internal
external
stimuli
enhance
transdermal
delivery
efficiency
robust
outcomes.
Some
studies
have
proposed
use
drug-free
a
promising
mechanotherapeutic
strategy
promote
wound
healing,
scar
removal,
hair
regeneration
via
mechanical
communication
pathway.
Although
several
advantages,
practical
application
suffers
problems
related
industrial
manufacture
clinical
evaluation,
making
it
difficult
translation.
In
this
study,
we
summarized
applications,
emerging
challenges,
developmental
prospects
provide
information
on
ways
advance
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(22)
Опубликована: Май 9, 2024
Hydrogels
have
emerged
as
promising
candidates
for
biomedical
applications,
especially
in
the
field
of
antibacterial
therapeutics,
due
to
their
unique
structural
properties,
highly
tunable
physicochemical
and
excellent
biocompatibility.
The
integration
stimuli-responsive
functions
into
hydrogels
holds
potential
enhance
properties
therapeutic
efficacy,
dynamically
responding
different
external
or
internal
stimuli,
such
pH,
temperature,
enzymes,
light.
Therefore,
this
review
describes
applications
hydrogel
dressings
responsive
stimuli
therapy.
collaborative
interaction
between
materials
is
discussed.
This
synergistic
approach,
contrast
conventional
materials,
not
only
amplifies
effect
but
also
alleviates
adverse
side
effects
diminishes
incidence
multiple
infections
drug
resistance.
provides
a
comprehensive
overview
current
challenges
outlines
future
research
directions
hydrogels.
It
underscores
imperative
ongoing
interdisciplinary
aimed
at
unraveling
mechanisms
wound
healing.
understanding
crucial
optimizing
design
implementation
Ultimately,
aims
offer
scientific
guidance
development
practical
clinical
application
dressings.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(17), С. 8632 - 8712
Опубликована: Янв. 1, 2024
Bioelectronics
is
a
hot
research
topic,
yet
an
important
tool,
as
it
facilitates
the
creation
of
advanced
medical
devices
that
interact
with
biological
systems
to
effectively
diagnose,
monitor
and
treat
broad
spectrum
health
conditions.
Electrical
stimulation
(ES)
pivotal
technique
in
bioelectronics,
offering
precise,
non-pharmacological
means
modulate
control
processes
across
molecular,
cellular,
tissue,
organ
levels.
This
method
holds
potential
restore
or
enhance
physiological
functions
compromised
by
diseases
injuries
integrating
sophisticated
electrical
signals,
device
interfaces,
designs
tailored
specific
mechanisms.
review
explains
mechanisms
which
ES
influences
cellular
behaviors,
introduces
essential
principles,
discusses
performance
requirements
for
optimal
systems,
highlights
representative
applications.
From
this
review,
we
can
realize
based
bioelectronics
therapy,
regenerative
medicine
rehabilitation
engineering
technologies,
ranging
from
tissue
neurological
modulation
cardiovascular
cognitive
functions.
underscores
versatility
various
biomedical
contexts
emphasizes
need
adapt
complex
clinical
landscapes
addresses.
