Facile fabrication of self-healing, injectable and antimicrobial cationic guar gum hydrogel dressings driven by hydrogen bonds

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 310, P. 120723 - 120723

Published: Feb. 20, 2023

Language: Английский

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An overview of conductive composite hydrogels for flexible electronic devices

Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 7(2)

Published: Feb. 17, 2024

Language: Английский

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Recent perspective of polymeric biomaterial in tissue engineering– a review

Materials Today Chemistry, Journal Year: 2023, Volume and Issue: 34, P. 101818 - 101818

Published: Nov. 18, 2023

Language: Английский

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Conductive hydrogels for bioenergy harvesting and self-powered application

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 138, P. 101156 - 101156

Published: June 23, 2023

Language: Английский

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Emerging Bioprinting for Wound Healing

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 11, 2023

Bioprinting has attracted much attention due to its suitability for fabricating biomedical devices. In particular, bioprinting become one of the growing centers in field wound healing, with various types bioprinted devices being developed, including 3D scaffolds, microneedle patches, and flexible electronics. Bioprinted can be designed specific biostructures biofunctions that closely match shape sites accelerate regeneration skin through approaches. Herein, a comprehensive review smart dressings is presented, emphasizing crucial effect determining biofunctions. The begins an overview techniques devices, followed in-depth discussion polymer-based inks, modification strategies, additive ingredients, properties, applications. strategies are divided into seven categories, chemical synthesis novel physical blending, coaxial bioprinting, multimaterial absorption, immobilization, hybridization living cells, examples presented. Thereafter, frontiers 4D artificial intelligence-assisted situ discussed from perspective interdisciplinary sciences. Finally, current challenges future prospects this highlighted.

Language: Английский

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Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects

Engineering, Journal Year: 2023, Volume and Issue: unknown

Published: June 1, 2023

Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly deliver therapeutics to site lesions, resulting in increased therapeutic efficacy while having minimum side effects. MNs are different kinds (e.g., small molecules, macromolecules, nanomedicines, living cells, bacteria, and exosomes) treating various disorders, including superficial tumors, wounds, infections, inflammatory diseases, abnormal appearance. The improved by integrating advantages multiple perform combination therapy. Through careful designing, further modified with biomimetic structures responsive drug release from internal external stimuli enhance transdermal delivery efficiency robust outcomes. Some studies have proposed use drug-free a promising mechanotherapeutic strategy promote wound healing, scar removal, hair regeneration via mechanical communication pathway. Although several advantages, practical application suffers problems related industrial manufacture clinical evaluation, making it difficult translation. In this study, we summarized applications, emerging challenges, developmental prospects provide information on ways advance

Language: Английский

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Hydrogel-based dressings designed to facilitate wound healing

Materials Advances, Journal Year: 2023, Volume and Issue: 5(4), P. 1364 - 1394

Published: Dec. 20, 2023

This review provides an overview of the functionalities hydrogel-based dressings and their role in promoting wound healing.

Language: Английский

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Stimuli‐Responsive Hydrogels for Antibacterial Applications

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 9, 2024

Hydrogels have emerged as promising candidates for biomedical applications, especially in the field of antibacterial therapeutics, due to their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration stimuli-responsive functions into hydrogels holds potential enhance properties therapeutic efficacy, dynamically responding different external or internal stimuli, such pH, temperature, enzymes, light. Therefore, this review describes applications hydrogel dressings responsive stimuli therapy. collaborative interaction between materials is discussed. This synergistic approach, contrast conventional materials, not only amplifies effect but also alleviates adverse side effects diminishes incidence multiple infections drug resistance. provides a comprehensive overview current challenges outlines future research directions hydrogels. It underscores imperative ongoing interdisciplinary aimed at unraveling mechanisms wound healing. understanding crucial optimizing design implementation Ultimately, aims offer scientific guidance development practical clinical application dressings.

Language: Английский

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All‐in‐One Self‐Powered Microneedle Device for Accelerating Infected Diabetic Wound Repair

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: Feb. 7, 2024

Abstract Diabetic wound healing remains a significant clinical challenge due to the complex microenvironment and attenuated endogenous electric field. Herein, novel all‐in‐one self‐powered microneedle device (termed TZ@mMN‐TENG) is developed by combining multifunctional carried tannin@ZnO microparticles (TZ@mMN) with triboelectric nanogenerator (TENG). In addition delivery of tannin Zn 2+ , TZ@mMN also effectively conducts electrical stimulation (ES) infected diabetic wounds. As device, TENG can convert biomechanical motion into exogenous ES accelerate healing. vitro experiment demonstrated that shows excellent conductive, high antioxidant ability, effective antibacterial properties against both Staphylococcus aureus Escherichia coli (>99% rates). Besides, TZ@mMN‐TENG promote cell proliferation migration. rat full‐thickness skin model eliminate bacteria, epidermal growth (regenerative epidermis: ≈303.3 ± 19.1 µm), enhance collagen deposition, inhibit inflammation (lower TNF‐α IL‐6 expression), angiogenesis (higher CD31 VEGF expression) repair. Overall, provides promising strategy for application in

Language: Английский

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Conductive Hyaluronic Acid/Deep Eutectic Solvent Composite Hydrogel as a Wound Dressing for Promoting Skin Burn Healing Under Electrical Stimulation

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)

Published: April 3, 2024

Abstract Burns can cause severe damage to the skin due bacterial infection and inflammation. Although conductive hydrogels as electroactive burn‐wound dressings achieve remarkable effects on accelerating wound healing, issues such imbalance between their high conductivity mechanical properties, easy dehydration, low transparency must be addressed. Herein, a double‐network eutectogel is fabricated by integrating polymerizable deep eutectic solvents (PDESs)including acrylamide/choline chloride/glycerol (acrylamide‐polymerization crosslink) thiolated hyaluronic acid (disulfide‐bonding crosslink). The introduction of PDESs provides with (up 0.25 S·m −1 ) strength (tensile strain 59–77%) simulating those natural human skin, well satisfactory tissue adhesiveness, self‐healing ability, antibacterial properties. When combined exogenous electrical stimulation, exhibits ability reduce inflammation, stimulate cell proliferation migration, promote collagen deposition angiogenesis, facilitate remodeling. This shows great potential dressing for healing major burn wounds.

Language: Английский

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