Future Foods,
Год журнала:
2024,
Номер
10, С. 100440 - 100440
Опубликована: Авг. 23, 2024
Seaweeds
are
incredibly
significant
marine
resources
that
have
the
ability
to
yield
beneficial
metabolites
and
bioactive
substances,
exhibiting
an
extensive
variety
of
biological
physiological
capabilities.
Seaweed
polysaccharides,
in
conjunction
with
other
components,
been
shown
exhibit
a
diverse
range
advantageous
characteristics.
These
include
antioxidant,
anticoagulant,
anti-inflammatory,
antiviral,
anticarcinogenic
effects.
The
assortment
constitution
polysaccharides
found
seaweed
crucial
factors
regulating
these
processes.
Agar,
alginate,
carrageenan,
fucoidan,
ulvan
abundant
seaweeds,
boosting
their
bioactivity.
Tissue
engineering,
drug
administration,
wound
healing
among
medical
applications
polysaccharides.
Algae-derived
exhibited
extraordinary
antiviral
properties,
which
makes
them
highly
promising
subjects
for
pharmacological
research.
Moreover,
numerous
mechanisms
recorded
encompassing
prevention
viral
coupling
or
entry
cell
host,
along
inhibition
DNA
replication
protein
synthesis.
also
potential
serve
as
long-term
solution
against
publicized
coronavirus,
has
caused
global
pandemic.
This
review
aims
analyze
seaweed-derived
explore
association
between
bioactivity
structural
compositions,
highlight
applications,
particularly
relation
activity.
Viruses,
Год журнала:
2022,
Номер
14(2), С. 426 - 426
Опубликована: Фев. 18, 2022
In
the
current
context
of
COVID-19
pandemic,
it
appears
that
our
scientific
resources
and
medical
community
are
not
sufficiently
developed
to
combat
rapid
viral
spread
all
over
world.
A
number
viruses
causing
epidemics
have
already
disseminated
across
world
in
last
few
years,
such
as
dengue
or
chinkungunya
virus,
Ebola
other
coronavirus
families
Middle
East
respiratory
syndrome
(MERS-CoV)
severe
acute
(SARS-CoV).
The
outbreaks
these
infectious
diseases
demonstrated
difficulty
treating
an
epidemic
before
creation
vaccine.
Different
antiviral
drugs
exist.
However,
several
them
cause
side
effects
lost
their
efficiency
because
virus
mutations.
It
is
essential
develop
new
strategies,
but
ones
rely
on
more
natural
compounds
decrease
secondary
effects.
Polysaccharides,
which
come
be
known
recent
years
for
medicinal
properties,
including
activities,
excellent
alternative.
They
metabolism
plants,
microorganisms,
animals,
directly
extractible.
Polysaccharides
attracted
attention
due
therapeutic
low
toxicity,
availability,
seem
attractive
candidates
tomorrow.
Bioengineering,
Год журнала:
2022,
Номер
9(9), С. 472 - 472
Опубликована: Сен. 14, 2022
The
marine
macroalgae
produce
a
collection
of
bioactive
polysaccharides,
which
the
sulfated
heteropolysaccharide
fucoidan
produced
by
brown
algae
class
Phaeophyceae
has
received
worldwide
attention
because
its
particular
biological
actions
that
confer
nutritional
and
health
benefits
to
humans
animals.
are
determined
their
structure
chemical
composition,
largely
influenced
geographical
location,
harvest
season,
extraction
process,
etc.
This
review
discusses
structure,
composition
physicochemical
properties
fucoidan.
action
applications
for
human
health,
tissue
engineering,
regenerative
medicine
drug
delivery
also
addressed.
industrial
scenario
prospects
research
depicted
would
give
an
insight
into
developing
as
commercially
viable
sustainable
material
in
pharmacological
sectors.
Marine Drugs,
Год журнала:
2021,
Номер
19(4), С. 219 - 219
Опубликована: Апрель 15, 2021
Much
attention
is
being
devoted
to
the
potential
of
marine
sulfated
polysaccharides
as
antiviral
agents
in
preventing
COVID-19.
In
this
study,
fucoidan
and
crude
polysaccharides,
extracted
from
six
seaweed
species
(Undaria
pinnatifida
sporophyll,
Laminaria
japonica,
Hizikia
fusiforme,
Sargassum
horneri,
Codium
fragile,
Porphyra
tenera)
Haliotis
discus
hannai
(abalone
viscera),
were
screened
for
their
inhibitory
activity
against
SARS-CoV-2
virus
entry.
Most
them
showed
significant
activities
at
an
IC50
12~289
μg/mL
pseudovirus
HEK293/ACE2,
except
P.
tenera
(IC50
>
1000
μg/mL).
The
polysaccharide
S.
horneri
strongest
activity,
with
12
μg/mL,
prevent
COVID-19
entry,
abalone
viscera
H.
fusiforme
could
also
inhibit
infection
33
47
respectively.
common
properties
these
which
have
strong
are
high
molecular
weight
(>800
kDa),
total
carbohydrate
(62.7~99.1%),
fucose
content
(37.3~66.2%),
highly
branched
polysaccharides.
These
results
indicated
that
seaweeds
can
effectively
Molecules,
Год журнала:
2022,
Номер
27(4), С. 1178 - 1178
Опубликована: Фев. 9, 2022
An
antiviral
agent
is
urgently
needed
based
on
the
high
probability
of
emergence
and
re-emergence
future
viral
disease,
highlighted
by
recent
global
COVID-19
pandemic.
The
may
be
seen
in
discovery
Alpha,
Beta,
Gamma,
Delta,
recently
discovered
Omicron
variants
SARS-CoV-2.
need
for
strategies
besides
testing
isolation,
social
distancing,
vaccine
development
clear.
One
includes
searching
an
that
provides
effective
results
without
toxicity,
which
well-presented
significant
carrageenan
nasal
spray
providing
efficacy
against
human
coronavirus-infected
patients.
As
primary
producer
sulfated
polysaccharides,
marine
plants,
including
macro-
microalgae,
offer
versatility
culture,
production,
post-isolation
obtaining
agent.
Therefore,
this
review
will
describe
attempt
to
highlight
search
practical
safe
agents
from
algal-based
polysaccharides
unveil
their
features
development.
Journal of Pure and Applied Microbiology,
Год журнала:
2022,
Номер
16(2), С. 1018 - 1027
Опубликована: Май 17, 2022
Coronavirus
disease
(COVID-19),
which
was
due
to
novel
coronavirus
detected
in
December
2019
Wuhan,
China
for
the
first
time
and
spread
rapidly
became
a
global
pandemic.
This
study
aimed
predict
potential
of
macroalgae
compounds
as
SARS-CoV-2
antiviral
by
inhibiting
ACE2
receptor
through
silico
approach.
Twenty-seven
were
obtained
from
PubChem
(NCBI,
USA),
while
target
protein
collected
Protein
Data
Bank
(PDB).
Then
initial
screening
drug-likeness
conducted
Lipinski
rule
five
web
server
prediction
bioactive
probability
carried
out
PASS
(Prediction
activity
spectra
biologically
active
substances)
Online
server.
After
those
approved
Lipinski’s
online
server,
blind
docking
simulation
performed
using
PyRx
0.8
software
show
binding
energy
value.
Molecular
interaction
analysis
done
BIOVIA
Discovery
Studio
2016
v16.1.0
PyMOL
v2.4.1
software.
There
are
six
Analysis.
The
result
is
that
compound
siphonaxanthin
among
27
showed
strong
bind
with
-8.8
kcal/mol.
also
used
drugs
positive
control:
remdesivir,
molnupiravir,
baricitinib,
lopinavir,
oseltamivir,
favipiravir.
shows
has
lowest
than
common
drug.
Macroalgae
predicted
have
antiviral.
Thus,
extension
studies
need
investigate
vitro
vivo
confirmation
siphonaxanthin’s
inhibitory
combat
SARS-CoV-2.
