Applied Microbiology and Biotechnology,
Год журнала:
2024,
Номер
108(1)
Опубликована: Янв. 13, 2024
Abstract
An
alarming
global
public
health
and
economic
peril
has
been
the
emergence
of
antibiotic
resistance
resulting
from
clinically
relevant
bacteria
pathogens,
including
Enterococcus
faecium
,
Staphylococcus
aureus
Klebsiella
pneumonia
Acinetobacter
baumannii
Pseudomonas
aeruginosa
Enterobacter
species
constantly
exhibiting
intrinsic
extrinsic
mechanisms
against
last-resort
antibiotics
like
gentamycin,
ciprofloxacin,
tetracycline,
colistin,
standard
ampicillin
prescription
in
clinical
practices.
The
discovery
applications
antimicrobial
peptides
(AMPs)
with
antibacterial
properties
have
considered
proven
as
alternative
agents
to
antibiotics.
In
this
study,
we
designed,
produced,
purified
a
recombinant
novel
multifunctional
hybrid
peptide
LL-37_Renalexin
for
first
time
via
application
newly
designed
flexible
GS
linker
coupled
use
our
previously
characterized
small
metal-binding
proteins
SmbP
CusF3H+
carrier
that
allow
an
enhanced
bacterial
expression,
using
BL21(DE3)
SHuffle
T7(DE3)
Escherichia
coli
strains,
purification
immobilized
metal
affinity
chromatography.
tag-free
exhibited
above
85%
reduction
colony-forming
units
broad-spectrum
effects
Methicillin-resistant
(MRSA),
pneumoniae
isolates
at
lower
minimum
inhibition
concentration
level
(10–33
μM)
compared
its
counterpart
single-AMPs
LL-37
Renalexin
(50–100
μM).
Key
points
•
linker.
was
expressed
CusF3H+.
shows
potency
isolates.
ACS Applied Nano Materials,
Год журнала:
2023,
Номер
6(11), С. 9071 - 9084
Опубликована: Май 19, 2023
Carbon
dots
(CDs),
as
rapidly
developing
nanomaterials,
give
new
prospects
for
the
treatment
of
various
diseases.
Their
great
biocompatibility
and
wide
specific
surface
area
make
CDs
excellent
drug-delivery
vehicles
because
they
improve
cellular
uptake
absorption
allow
medications
to
bind
more
easily.
offer
enormous
potential
delivery
systems
antiinflammatory
medications.
The
activities
drugs
delivered
by
are
higher
than
those
free
drugs.
They
also
have
controlled
release,
thus
enhancing
cumulative
effect
at
inflammation
site
improving
pharmacokinetics.
Compared
with
small-molecule
antibacterial
medicines,
CD-based
efficacies,
better
targeting,
increased
internalization
efficiency,
decreased
systemic
side
effects.
benefits
using
anticancer
drug
carriers
include
high
loading,
lower
dosage,
regulated
synergistic
photothermal
therapy,
which
offers
a
novel
approach
diagnosis
cancer
in
clinical
settings.
However,
it
is
important
consider
biosafety,
toxicity,
impact
on
immune
system
an
organism
before
them
therapy.
This
review
discusses
use
antiinflammatory,
antibacterial,
summarizes
current
advantages
challenges
delivery.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(2)
Опубликована: Окт. 13, 2023
Diabetic
chronic
wounds
cause
a
significant
amount
of
pain
to
patients
because
their
low
cure
rates
and
high
recurrence
rates.
Traditional
approaches
treating
diabetic
often
involve
the
delivery
drugs
or
cytokines
that
regulate
microenvironment
eliminate
bacterial
infection
in
wound
area,
but
they
are
passive
controlling
cell
behaviors
may
lead
drug
resistance.
Emerging
drug-free
treatments
important
for
convenient,
effective,
safe
treatment
strategies.
However,
current
cannot
fully
promote
tissue
regeneration
prevent
infections.
Here,
efficacy
negatively
charged
fiber
dressing
promoting
healing
is
investigated.
The
can
generate
reactive
oxygen
species
inhibit
reproduction
with
assistance
ultrasound
during
inflammatory
phase.
Furthermore,
provides
an
electrostatic
field
regulates
cellular
behavior
proliferative
phases.
In
particular,
fibroblast
migration
induce
macrophage
polarization
neovascularization
without
any
additional
drugs.
It
demonstrated
this
strategy
enables
mouse
model,
achieving
effective
closure
over
12-day
cycle
providing
therapeutic
care.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(33)
Опубликована: Март 22, 2024
Abstract
Sonodynamic
therapy
(SDT)
has
demonstrated
significant
potential
in
addressing
multidrug‐resistant
bacterial
infections
due
to
its
noninvasive
nature
and
independence
from
antibiotics
light
sources.
However,
the
majority
of
current
sonosensitizers
exhibit
aggregation‐caused
quenching
(ACQ),
leading
low
reactive
oxygen
species
(ROS)
generation
efficiency.
Herein,
a
novel
nonplanar
structured
sonodynamic
(4,4‐difluoro‐4‐boron‐3a,4‐diaza‐indandiene)
BODIPY
derivative,
BODN,
with
aggregation‐induced
emission
(AIE)
properties,
rapid
substantial
ROS
by
ultrasound
is
introduced.
The
BODN
co‐assembled
commercial
amphiphilic
polymer,
mDSPE‐PEG
2000
,
forming
nanoparticles
(BODN‐NP).
Under
conditions,
BODN‐NP
demonstrates
potent
antimicrobial
activity
improves
inflammatory
response
promote
healing
wounds
infected
both
Staphylococcus
aureus
methicillin‐resistant
.
This
work
expands
use
AIE
materials
provides
new
perspectives
for
innovative
solutions
against
infections.
Fermentation,
Год журнала:
2025,
Номер
11(1), С. 36 - 36
Опубликована: Янв. 17, 2025
The
article
reviews
the
literature
on
antimicrobial
peptides
(AMPs)
that
exhibit
unique
mechanisms,
such
as
broad-spectrum
activity,
low
development
of
resistance,
and
ability
to
modulate
immune
response
host
organism.
Information
is
provided
significant
potential
AMPs
in
fight
against
pathogens
threatening
human
health
food
safety.
Enrichment
diet
with
biologically
active
obtained
using
proteolytic
activity
lactic
acid
bacteria
(LAB)
proposed
a
simple,
accessible,
viable
alternative
antibiotics
does
not
have
harmful
side
effect.
review
briefly
covers
methods
for
obtaining
features
LAB
system
responsible
producing
bioactive
environment.
It
has
been
shown
various
strains
makes
it
possible
produce
high-quality
whey-based
beverages
different
directions
antagonistic
opportunistic
helps
optimize
gastrointestinal
microbiota.
assumed
drinks
can
reduce
dose
antimicrobials
combined
therapy
infectious
diseases
be
preventive
measure
contagion
spread
resistance.
Biomaterials Science,
Год журнала:
2023,
Номер
11(18), С. 6013 - 6034
Опубликована: Янв. 1, 2023
Polyhydroxyalkanoates
(PHAs),
a
family
of
natural
microbial
biopolyesters
via
with
excellent
biodegradability
and
biosafety,
can
be
produced
optimally
synthetic
biology
designed
to
various
medical
devices
for
applications.
Life,
Год журнала:
2023,
Номер
13(5), С. 1161 - 1161
Опубликована: Май 11, 2023
Antimicrobial
resistance
is
a
phenomenon
that
the
present-day
world
witnessing
poses
serious
threat
to
global
health.
The
decline
in
development
of
novel
therapeutics
over
last
couple
decades
has
exacerbated
situation
further.
In
this
scenario,
pursuit
new
alternative
commonly
used
antibiotics
gained
predominance
amongst
researchers
across
world.
peptides
(AMPs)
from
natural
sources
have
drawn
significant
interest
recent
years
as
promising
pharmacological
substitutes
conventional
antibiotics.
most
notable
advantage
AMPs
microorganisms
cannot
develop
them.
Insects
represent
one
potential
AMPs,
which
are
synthesized
part
an
innate
immune
defence
against
invading
pathogens.
different
insects
been
extensively
studied,
and
silkworm
Diverse
classes
(including
attacins,
cecropins,
defensins,
enbocins,
gloverins,
lebocins
moricins)
were
identified
exhibit
antimicrobial
property
bacteria,
fungi
viruses,
indicating
their
therapeutic
benefits.
This
review
briefs
about
responses
pathogens,
isolation
silkworms,
reported
silkworms
activity
various
microorganisms.
