The Impact of Microplastics in Food and Drugs on Human Health: A Review of the MENA Region DOI Open Access

Noha Alziny,

Fadya M. Elgarhy, Asmaa Eldesouky Mohamed

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2025, Номер 22(3), С. 380 - 380

Опубликована: Март 5, 2025

Microplastics (MPs), defined as plastic particles smaller than 5 mm, have emerged a global environmental and public health crisis, infiltrating air, water, soil, food systems worldwide. MPs originate from the breakdown of larger debris, single-use plastics, industrial processes, entering food. Emerging evidence underscores ability to cross biological barriers, including blood–brain barrier, triggering neuroinflammatory responses contributing neurodegenerative diseases such Alzheimer’s Parkinson’s. Polystyrene (PS), common type MP, activates microglial cells, releasing pro-inflammatory cytokines like tumor necrosis factor (TNF-α) interleukins, which increase neuronal damage. also been linked cardiovascular diseases, with studies detecting polyethylene (PE) polyvinyl chloride (PVC) in carotid artery plaques, increasing risk myocardial infarction stroke. Furthermore, disrupt endocrine function, alter lipid metabolism, induce gut microbiome imbalances, posing multifaceted risks. In MENA region, MP pollution is particularly severe, Mediterranean Sea receiving an estimated 570,000 tons annually, equivalent 33,800 bottles per minute. Studies Egypt, Lebanon, Tunisia document high concentrations marine ecosystems, herbivorous fish Siganus rivulatus containing over 1000 individual due ingestion contaminated seaweed. Despite these findings, awareness regulatory frameworks remain inadequate, only 24% Egyptians demonstrating sufficient knowledge safe use. This review emphasizes urgent need for region-specific research, policy interventions, campaigns address pollution. Recommendations include sustainable waste management practices, promotion biodegradable alternatives, enhanced monitoring mitigate impacts region.

Язык: Английский

The effects of micro- and nanoplastics on the central nervous system: A new threat to humanity? DOI

Yanxu Zheng,

Shengchao Xu, Jingyu Liu

и другие.

Toxicology, Год журнала: 2024, Номер 504, С. 153799 - 153799

Опубликована: Апрель 11, 2024

Язык: Английский

Процитировано

8
Piezoelectric materials for neuroregeneration: a review DOI
Linliang Wu, Hongxia Gao,

Qi Han

и другие.

Biomaterials Science, Год журнала: 2023, Номер 11(22), С. 7296 - 7310

Опубликована: Янв. 1, 2023

The purpose of nerve regeneration via tissue engineering strategies is to create a microenvironment that mimics natural growth for achieving functional recovery. Biomaterial scaffolds offer promising option the clinical treatment large gaps due rapid advancement materials science and regenerative medicine. design biomimetic should take into account inherent properties its environment, such as stiffness, topography, adhesion, conductivity, chemical functionality. Various advanced techniques have been employed develop suitable repair. Since neuronal cells electrical activity, transmission bioelectrical signals crucial recovery nerves. Therefore, an ideal peripheral scaffold activity similar those nerves, in addition delicate structure. Piezoelectric can convert stress changes activate different intracellular signaling pathways critical cell function, which makes them potentially useful regeneration. However, comprehensive review piezoelectric neuroregeneration still lacking. Thus, this systematically summarizes development their application field First, piezoelectricity phenomenon various organisms are briefly introduced. Second, most commonly used neural engineering, including biocompatible polymers, inorganic materials, classified discussed. Finally, challenges future research directions proposed.

Язык: Английский

Процитировано

22
Bamboo as a substitute for plastic: Underlying mechanisms of flexible deformation and flexural toughness of bamboo at multiple scales DOI
Xin Wei, Shaohua Gu, Xianjun Li

и другие.

Industrial Crops and Products, Год журнала: 2023, Номер 204, С. 117351 - 117351

Опубликована: Авг. 25, 2023

Язык: Английский

Процитировано

19
NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity DOI Creative Commons
Andi Alijagić, Alexander Hedbrant, Alexander Persson

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Апрель 18, 2023

Micro- and nanoplastics (MNPs) are emerging pollutants with scarcely investigated effects on human innate immunity. If they follow a similar course of action as other, more thoroughly particulates, MNPs may penetrate epithelial barriers, potentially triggering cascade signaling events leading to cell damage inflammation. Inflammasomes intracellular multiprotein complexes stimulus-induced sensors critical for mounting inflammatory responses upon recognition pathogen- or damage-associated molecular patterns. Among these, the NLRP3 inflammasome is most studied in terms activation

Язык: Английский

Процитировано

18
An Emerging Role of Micro- and Nanoplastics in Vascular Diseases DOI Creative Commons

Seung Eun Lee,

Hyun Kyung Yoon,

Do Yun Kim

и другие.

Life, Год журнала: 2024, Номер 14(2), С. 255 - 255

Опубликована: Фев. 16, 2024

Vascular diseases are the leading causes of death worldwide, and they attributable to multiple pathologies, such as atherosclerosis, diabetes, chronic obstructive pulmonary disease. Exposure various environmental contaminants is associated with development diseases, including vascular diseases. Among contaminants, micro- nanoplastics have gained attention global risk factors that threaten human health. Recently, extensive research has been conducted on effects In this review, we highlight

Язык: Английский

Процитировано

7
Micro(nano)-plastics exposure induced programmed cell death and corresponding influence factors DOI

Qingchun Wu,

Jianzhong Cao,

Xuting Liu

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 921, С. 171230 - 171230

Опубликована: Фев. 23, 2024

Язык: Английский

Процитировано

6
Impact of polystyrene nanoplastics on apoptosis and inflammation in zebrafish larvae: Insights from reactive oxygen species perspective DOI

Jincheng Pei,

Shannan Chen, Li Li

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 948, С. 174737 - 174737

Опубликована: Июль 14, 2024

Язык: Английский

Процитировано

6
A549 as an In Vitro Model to Evaluate the Impact of Microplastics in the Air DOI Creative Commons
Chman Shahzadi, Alessandra Di Serafino, Eleonora Aruffo

и другие.

Biology, Год журнала: 2023, Номер 12(9), С. 1243 - 1243

Опубликована: Сен. 15, 2023

Airborne microplastics raise significant concerns due to their potential health impacts. Having a small size, larger surface area, and penetrative ability into the biological system, makes them hazardous health. This review article compiles various studies investigating mechanism of action polystyrene micro- nanoplastics affecting lung epithelial cells A549. These inhalable damage respiratory by triggering proinflammatory environment, genotoxicity, oxidative stress, morphological changes, cytotoxic accumulation in A549 cells. PS-NP toxicity depends on factors such as modifications, concentration, charge, zeta potential. However, cellular uptake cytotoxicity mechanisms depend cell type. For cells, PS-NPs are responsible for energy imbalance mitochondrial dysfunction, stress-mediated cytotoxicity, immunomodulation, apoptosis. Additionally, have traverse placental barrier, posing risk offspring. Despite advancements, precise underlying how prolonged exposure leads development progression diseases unclear points, necessitating further investigations unravel root cause. also sheds light data gaps, inconsistencies PS-Nos research, provides recommendations research this field.

Язык: Английский

Процитировано

15
It matters how we measure - Quantification of microplastics in drinking water by μFTIR and μRaman DOI Creative Commons
Luca Maurizi, Lucian Iordachescu, Inga V. Kirstein

и другие.

Heliyon, Год журнала: 2023, Номер 9(9), С. e20119 - e20119

Опубликована: Сен. 1, 2023

The water treatment for microplastics (MP) at a Danish groundwater-based waterworks was assessed by Fourier-Transform IR micro-spectroscopy (μFTIR) (nominal size limit 6.6 μm) and compared to results from Raman (μRaman) 1.0 on the same sample set. MP abundance waterworks' inlet outlet quantified as counts per cubic metre (N/m3) estimated mass (μg/m3). removal efficiency found be higher when analysing μFTIR (counts: 78.14 ± 49.70%, mass: 98.73 11.10%) less fluctuating than using μRaman 43.2%, 75.1%). However, both techniques pointed value of ∼80% counts' MPs >6.6 μm. Contrarily what shown μRaman, no systematic leaking plastic elements facility could identified dataset, either (inlet 31.86 17.17 N/m3, 4.98 2.09 N/m3) or estimate 76.30 106.30 μg/m3, 2.81 2.78 μg/m3). estimation human intake drinking calculated data (5 N/(year·capita)) proved approximately 332 times lower that although in line with previous studies employing μFTIR. By merging length datasets two techniques, it false negatives became prevalent dataset already below 50 Further, fitting overall frequency ranges power function, missed 95.7% extrapolated population (1-1865.9 μm). Consequently, relying only may have led underestimating content investigated water, most 1-50 μm would been missed.

Язык: Английский

Процитировано

13
Knockdown of LCN2 Attenuates Brain Injury After Intracerebral Hemorrhage via Suppressing Pyroptosis DOI Creative Commons
Yangyang Zhao, Qiuxiang Xiao, Tao Sun

и другие.

Neuropsychiatric Disease and Treatment, Год журнала: 2024, Номер Volume 20, С. 83 - 99

Опубликована: Янв. 1, 2024

Objective: The aims of this study are to screen novel differentially expressed genes (DEGs) for intracerebral hemorrhage (ICH) and reveal the role Lipocalin-2 (LCN2) in ICH. Methods: We constructed ICH model by injection autologous whole blood into right basal ganglia rats. RNA-sequencing bioinformatics analyses were performed identify DEGs between sham rats, some important ones confirmed using quantitative real-time PCR (qRT-PCR). LCN shRNA was used knockdown LCN2 Pathological examination carried out 2,3,5-triphenyltetrazolium chloride (TTC) staining Hematoxylin-eosin (HE) staining. Immunohistochemistry detected Caspase-3, co-staining Terminal dUTP nick end labeling (TUNEL) NEUN neuron apoptosis assessment. Western blot analysis quantify pyroptosis-related proteins. Enzyme-linked immunosorbent assay (ELISA) measure inflammatory cytokine levels. Results: rats exhibited significant hematomas, higher brain water content, obvious interstitial edema, infiltration, as well more apoptotic cells tissues. RNA-seq identified 103 upregulated 81 downregulated DEGs. expression LCN2, HSPB1, CXCL10, MEF2B triggered release interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), IL-18, promoted proteins Caspase-1, GSDMD, NLRP3, ASC. attenuated pathological characteristics ICH, also reduced pyroptosis Conclusion: Inhibition attenuates injury after via suppressing pyroptosis, which provide guidance management. Keywords: hemorrhage, inflammation, lipocalin-2

Язык: Английский

Процитировано

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