Journal of drug targeting,
Год журнала:
2023,
Номер
31(8), С. 794 - 816
Опубликована: Авг. 1, 2023
One
of
the
most
common
cancers
that
occur
in
females
is
breast
cancer.
Despite
significant
leaps
and
bounds
have
been
made
treatment
cancer,
disease
remains
one
leading
causes
death
among
women
a
major
public
health
challenge.
The
therapeutic
efficacy
chemotherapeutics
hindered
by
chemoresistance
toxicity.
Nano-based
lipid
drug
delivery
systems
offer
controlled
release,
nanometric
size
site-specific
targeting.
Breast
cancer
includes
surgery,
chemotherapy
radiotherapy.
this,
no
single
method
for
condition
currently
effective
due
to
stem
cell
metastasis
chemo-resistance.
Therefore,
employment
nanocarrier
necessary
order
target
cells.
This
article
addresses
options,
including
modern
procedures
such
as
chemotherapy,
etc.
some
innovative
options
highlighting
role
lipidic
nanocarriers
loaded
with
chemotherapeutic
drugs
nanoemulsion,
solid-lipid
nanoparticles,
nanostructured
carriers
liposomes,
their
investigations
demonstrated
they
can
limit
growth,
reduce
risk
recurrence,
well
minimise
post-chemotherapy
metastasis.
also
explores
FDA-approved
lipid-based
nanocarriers,
commercially
available
formulations,
ligand-based
formulations
are
being
considered
further
research.
Skin
cancer
has
emerged
as
the
fifth
most
commonly
reported
in
world,
causing
a
burden
on
global
health
and
economy.
The
enormously
rising
environmental
changes,
industrialization,
genetic
modification
have
further
exacerbated
skin
statistics.
Current
treatment
modalities
such
surgery,
radiotherapy,
conventional
chemotherapy,
targeted
therapy,
immunotherapy
are
facing
several
issues
related
to
cost,
toxicity,
bioavailability
thereby
leading
declined
anti-skin
therapeutic
efficacy
poor
patient
compliance.
In
context
of
overcoming
this
limitation,
nanotechnological
advancements
been
witnessed
so
far.
Among
various
nanomaterials,
nanoparticles
endowed
exorbitant
advantages
by
acting
both
agents
drug
carriers
for
remarkable
cancer.
small
size
large
surface
area
volume
ratio
escalate
tumor
uptake
through
their
leaky
vasculature
resulting
enhanced
efficacy.
context,
present
review
provides
up
date
information
about
different
types
pathology
cancer,
followed
current
associated
drawbacks.
Furthermore,
it
meticulously
discusses
role
numerous
inorganic,
polymer,
lipid-based
therapy
with
subsequent
descriptions
patents
clinical
trials.
ACS Omega,
Год журнала:
2023,
Номер
8(16), С. 14290 - 14320
Опубликована: Апрель 10, 2023
Cancer
is
ranked
as
the
second
leading
cause
of
death
globally.
Traditional
cancer
therapies
including
chemotherapy
are
flawed,
with
off-target
and
on-target
toxicities
on
normal
cells,
requiring
newer
strategies
to
improve
cell
selective
targeting.
The
application
nanomaterial
has
been
extensively
studied
explored
chemical
biology
tools
in
theranostics.
It
shows
greater
applications
toward
stability,
biocompatibility,
increased
permeability,
resulting
precise
targeting,
mitigating
shortcomings
traditional
therapies.
nanoplatform
offers
an
exciting
opportunity
gain
targeting
multifunctionality.
advent
nanotechnology,
particular
development
smart
nanomaterials,
transformed
diagnosis
treatment.
large
surface
area
nanoparticles
enough
encapsulate
many
molecules
ability
functionalize
various
biosubstrates
such
DNA,
RNA,
aptamers,
antibodies,
which
helps
theranostic
action.
Comparatively,
biologically
derived
nanomaterials
perceive
advantages
over
produced
by
conventional
methods
terms
economy,
ease
production,
reduced
toxicity.
present
review
summarizes
techniques
theranostics
emphasizes
(such
organic
(NPs),
inorganic
NPs,
carbon-based
NPs).
We
also
critically
discussed
challenges
impeding
their
translation
treatment
diagnostic
applications.
This
concludes
that
use
could
significantly
will
facilitate
new
dimensions
for
tumor
detection
therapy.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 16, 2023
Nanoparticle
drug
delivery
systems
have
proved
anti-tumor
effects;
however,
they
are
not
widely
used
in
tumor
therapy
due
to
insufficient
ability
target
specific
sites,
multidrug
resistance
drugs,
and
the
high
toxicity
of
drugs.
With
development
RNAi
technology,
nucleic
acids
been
delivered
sites
replace
or
correct
defective
genes
knock
down
genes.
Also,
synergistic
therapeutic
effects
can
be
achieved
for
combined
delivery,
which
is
more
effective
overcoming
cancer
cells.
These
combination
therapies
achieve
better
than
delivering
chemotherapeutic
drugs
alone,
so
scope
has
also
expanded
three
aspects:
drug-drug,
drug-gene,
gene-gene.
This
review
summarizes
recent
advances
nanocarriers
co-delivery
agents,
including
i)
characterization
preparation
nanocarriers,
such
as
lipid-based
polymer
inorganic
carriers;
ii)
advantages
disadvantages
approaches;
iii)
effectual
cases
that
applied
systems;
iv)
future
perspectives
design
nanoparticle
co-deliver
agents.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Апрель 10, 2024
Cancer
is
a
severe
disease
that
results
in
death
all
countries
of
the
world.
A
nano-based
drug
delivery
approach
best
alternative,
directly
targeting
cancer
tumor
cells
with
improved
cellular
uptake.
Different
types
nanoparticle-based
carriers
are
advanced
for
treatment
cancer,
and
to
increase
therapeutic
effectiveness
safety
therapy,
many
substances
have
been
looked
into
as
carriers.
Lipid-based
nanoparticles
(LBNPs)
significantly
attracted
interest
recently.
These
natural
biomolecules
alternate
other
polymers
frequently
recycled
medicine
due
their
amphipathic
properties.
Lipid
typically
provide
variety
benefits,
including
biocompatibility
biodegradability.
This
review
covers
different
classes
LBNPs,
characterization
synthesis
technologies.
discusses
most
significant
advancements
lipid
nanoparticle
technology
use
administration.
Moreover,
also
emphasized
applications
used
types.
Frontiers in Nanotechnology,
Год журнала:
2024,
Номер
6
Опубликована: Окт. 21, 2024
Nanoparticles
are
attractive
therapeutic
tools
due
to
their
distinctive
characteristics,
including
more
accurate
drug
delivery,
improved
bioavailability,
and
enhanced
targeted
therapy.
This
review
offers
a
comprehensive
analysis
of
the
potentials
cutting-edge
nanoparticles
as
demonstrated
in
human
clinical
trials,
based
on
empirical
evidence.
Through
systematic
searches
major
scientific
databases,
relevant
studies
published
up
March
2024
were
included,
focusing
trials
utilizing
advanced
for
purposes.
The
discusses
diverse
applications
oncology,
infectious
diseases,
neurology,
other
medical
fields.
Additionally,
it
scrutinizes
safety
profiles,
efficacy
outcomes,
challenges
associated
with
nanoparticle-based
therapies.
findings
underscore
significant
progress
translating
nanoparticle
research
into
practice
highlight
potential
these
innovative
platforms
revolutionize
treatments.
contributes
valuable
insights
growing
field
therapeutics,
fostering
deeper
understanding
implications
practice.
Since
their
inception
in
the
early
1960s,
development
and
use
of
nanoscale
materials
have
progressed
tremendously,
roles
diverse
fields
ranging
from
human
health
to
energy
electronics
are
undeniable.
The
application
nanotechnology
inventions
has
revolutionized
many
aspects
everyday
life
including
various
medical
applications
specifically
drug
delivery
systems,
maximizing
therapeutic
efficacy
contained
drugs
by
means
bioavailability
enhancement
or
minimization
adverse
effects.
In
this
review,
we
utilize
CAS
Content
Collection,
a
vast
repository
scientific
information
extracted
journal
patent
publications,
analyze
trends
nanoscience
research
relevant
an
effort
provide
comprehensive
detailed
picture
field.
We
examine
publication
landscape
area
insights
into
current
knowledge
advances
developments.
review
major
classes
nanosized
routes,
targeted
diseases.
outline
most
discussed
concepts
assess
advantages
nanocarriers.
objective
is
broad
overview
evolving
regarding
challenges,
evaluate
growth
opportunities.
merit
stems
extensive,
wide-ranging
coverage
up-to-date
information,
allowing
unmatched
breadth
analysis
in-depth
insights.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Март 23, 2023
Cancer
causes
significant
mortality
and
morbidity
worldwide,
but
existing
pharmacological
treatments
are
greatly
limited
by
the
inherent
heterogeneity
of
cancer
as
a
disease,
well
unsatisfactory
efficacy
specificity
therapeutic
drugs.
Biopharmaceutical
barriers
such
low
permeability
poor
water
solubility,
along
with
absence
active
targeting
capabilities,
often
result
in
suboptimal
clinical
results.
The
difficulty
successfully
reaching
destroying
tumor
cells
is
also
compounded
undesirable
impacts
on
healthy
tissue,
including
off-target
effects
high
toxicity,
which
further
impair
ability
to
effectively
manage
disease
optimize
patient
outcomes.
However,
last
few
decades,
development
nanotherapeutics
has
allowed
for
use
rational
design
order
maximize
success.
Advances
fabrication
nano-sized
delivery
systems,
coupled
variety
surface
engineering
strategies
promote
customization,
have
resulted
promising
approaches
targeted,
site-specific
drug
fewer
unwanted
better
efficacy.
These
nano
systems
been
able
overcome
some
challenges
conventional
related
pharmacokinetics,
biodistribution,
target
specificity.
In
particular,
lipid-based
nanosystems
extensively
explored
due
their
biocompatibility,
versatility,
adaptability.
Lipid-based
treatment
varied
diverse,
liposomal
therapeutics,
lipidic
nanoemulsions,
solid
lipid
nanoparticles,
nanostructured
carriers,
lipid-polymer
nanohybrids,
supramolecular
nanolipidic
structures.
This
review
aims
provide
an
overview
diverse
formulations
lipid-engineered
current
field,
researchers
attempt
translate
these
from
bench
clinic.
