Abstract
Chronic
wounds,
as
a
kind
of
long‐term
disease
that
is
difficult
to
cure,
are
challenged
in
healthcare,
placing
substantial
physical,
emotional,
and
economic
burdens
on
patients
society.
Effective
treatment
chronic
wounds
essential
for
improving
patient
quality
life,
reducing
healthcare
costs,
alleviating
the
strain
medical
resources.
Hydrogel
materials
have
emerged
promising
candidates
wound
due
their
exceptional
adaptability
environments
ability
deliver
various
therapeutic
agents,
effectively
promoting
healing
wounds.
However,
wide
array
available
with
diverse
functionalities
presents
challenge
selecting
most
appropriate
components
synthesizing
hydrogel
dressings.
This
review
summarizes
common
materials,
including
properties,
cross‐linking
methods,
applications.
Additionally,
it
systematically
categorizes
different
elucidating
action
mechanisms
effects.
Furthermore,
this
work
offers
guidance
material
selection
dressing
design
based
characteristics
Finally,
challenges
future
perspectives
composite
hydrogels
field
dressings
discussed.
provides
readers
comprehensive
understanding
reliable
basis
synthesize
ideal
Materials & Design,
Год журнала:
2024,
Номер
238, С. 112714 - 112714
Опубликована: Янв. 30, 2024
Among
the
fabrication
methods,
3D
printing
due
to
excellent
accuracy,
reproducibility
and
customizability
as
well
electrospinning
ability
mimic
extracellular
matrix
structure
have
received
many
attentions.
Herein,
we
used
combination
of
both
mentioned
techniques
produce
a
biomimetic
bilayer
scaffold
for
skin
tissue
regeneration.
The
upper
layer
was
made
printed
dextran-vascular
endothelial
growth
factor
(Dex-VEGF)
stimulate
angiogenesis
cell
migration,
bottom
electrospun
gelatin-keratin
(Gel-Kr)
nanofibers
induce
attachment.
tensile
strength
elastic
modulus
scaffolds
were
measured
in
range
0.26
–
0.33
MPa
5.8
7.2
MPa,
respectively.
investigations
revealed
that
release
VEGF
lasted
up
7
days.
VEGF-loaded
demonstrated
best
cellular
behaviour.
Chicken
chorioallantoic
membrane
(CAM)
assay
confirmed
highest
angiogenic
potential
presence
scaffold.
Also,
based
on
vivo
animal
studies
histopathological
immunohistochemical
examinations,
wound
healing
rate
related
within
14
obtained
promising
results
introduce
prepared
perfect
construct
accelerate
healing.
Materials & Design,
Год журнала:
2023,
Номер
227, С. 111744 - 111744
Опубликована: Фев. 13, 2023
Skin
wounds
accompanied
by
massive
bleeding
and
bacterial
infection
can
be
life-threatening
pose
a
significant
challenge
to
clinical
wound
management.
Herein,
we
prepared
gellan
gum/sericin
hydrogels
containing
PDA-encapsulated
halloysite
nanotubes
(halloysite@polydopamine)
achieve
fast
hemostasis
photothermally
antibacterial
effects.
The
morphology
compressive
properties
of
the
composite
were
characterized,
biocompatibility
was
investigated
hemocompatibility
cytocompatibility
tests.
hemostatic
further
evaluated
in
rat
liver
hemorrhage
tail
amputation
model.
mechanical
performance
(compressive
strength
353.2
KPa)
effect
(30.33
±
3.68
s
injury
model
28.33
2.35
caudal
model)
hydrogel
improved
due
introduction
halloysite@polydopamine.
In
addition,
rapidly
heated
under
808
nm
near-infrared
(NIR)
light
irradiation,
making
extremely
effective
against
E.
coli
S.
aureus.
Furthermore,
closure
rate,
granulation
tissue
thickness,
collagen
deposition,
expression
inflammation-associated
cytokines
(CD68)
angiogenesis-associated
(CD31)
full-thickness
skin
defect
infected
with
All
results
showed
that
this
multifunctional
provided
better
healing
effects,
suggesting
has
become
promising
alternative
for
repair.
Biomacromolecules,
Год журнала:
2024,
Номер
25(4), С. 2438 - 2448
Опубликована: Март 19, 2024
The
treatment
of
infected
wounds
faces
substantial
challenges
due
to
the
high
incidence
and
serious
infection-related
complications.
Natural-based
hydrogel
dressings
with
favorable
antibacterial
properties
strong
applicability
are
urgently
needed.
Herein,
we
developed
a
composite
by
constructing
multiple
networks
loading
ciprofloxacin
for
wound
healing.
was
synthesized
via
Schiff
base
reaction
between
carboxymethyl
chitosan
oxidized
sodium
alginate,
followed
polymerization
acrylamide
monomer.
resultant
dressing
possessed
good
self-healing
ability,
considerable
compression
strength,
reliable
fatigue
resistance.
In
vitro
assessment
showed
that
effectively
eliminated
bacteria
exhibited
an
excellent
biocompatibility.
model
