Опубликована: Янв. 1, 2024
Язык: Английский
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Ноя. 28, 2023
The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for advancing cancer treatment. formation is multifaceted process influenced by genetic, epigenetic, and environmental factors. offer distinctive platform investigating the origin cancer, paving way novel approaches to treatment, drug testing, tailored medical interventions. This review article will provide an overview science behind iPSCs, current limitations challenges iPSC-based therapy, ethical social implications, comparative analysis with other types also discuss applications tumorigenesis, future tumorigenesis highlight successful case studies utilizing research. conclusion summarize advancements made research importance continued investment iPSC unlock full potential these cells.
Язык: Английский
Процитировано
67
Biomedicines, Год журнала: 2023, Номер 11(6), С. 1579 - 1579
Опубликована: Май 30, 2023
Glioblastoma (GBM) is the most aggressive glial tumor of central nervous system. Despite intense scientific efforts, patients diagnosed with GBM and treated current standard care have a median survival only 15 months. Patients are initially by neurosurgeon goal maximal safe resection tumor. Obtaining tissue samples during surgery indispensable for diagnosis GBM. Technological improvements, such as navigation systems intraoperative monitoring, significantly advanced possibility gross resection. Usually within six weeks after surgery, concomitant radiotherapy chemotherapy temozolomide initiated. However, regimens based on population-level studies could also be improved. Implementing artificial intelligence in planning might used to individualize treatment plans. Furthermore, detailed genetic molecular markers provide patient-tailored immunochemotherapy. In this article, we review possibilities personalizing these treatments. Additionally, discuss novel individualized therapeutic options encouraging results. Due inherent heterogeneity GBM, applying prolong patients.
Язык: Английский
Процитировано
25
CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(5)
Опубликована: Май 1, 2024
Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives
Язык: Английский
Процитировано
11
Advanced Materials, Год журнала: 2024, Номер 36(18)
Опубликована: Фев. 1, 2024
The application of nanomedicines for glioblastoma (GBM) therapy is hampered by the blood-brain barrier (BBB) and dense tissue. To achieve efficient BBB crossing deep GBM penetration, this work demonstrates a strategy active transcellular transport mitochondrion-disturbing nanomedicine, pGBEMA
Язык: Английский
Процитировано
9
Cambridge Quarterly of Healthcare Ethics, Год журнала: 2023, Номер 32(4), С. 582 - 596
Опубликована: Июнь 8, 2023
Human brain organoids (HBOs) are three-dimensional biological entities grown in the laboratory order to recapitulate structure and functions of adult human brain. They can be taken novel living for their specific features uses. As a contribution ongoing discussion on use HBOs, authors identify three sets reasons moral concern. The first set regards potential emergence sentience/consciousness HBOs that would endow them with status whose perimeter should established. second concerns has do an analogy artificial womb technology. technical realization processes typically connected physiology body create manipulatory instrumental attitude undermine protection what is human. third new frontiers biocomputing creation chimeras. far as frontier organoid intelligence concerned, it close relationship humans interfaces having components capable mimicking memory cognition raises ethical issues. chimeras humanization nonhuman animals worthy scrutiny. A detailed description these issues provided contribute construction regulative framework guide decisions when considering research field HBOs.
Язык: Английский
Процитировано
12
Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11
Опубликована: Авг. 10, 2023
Tumor immunotherapy has made great progress in cancer treatment but still faces several challenges, such as a limited number of targetable antigens and varying responses among patients. Alternative splicing (AS) is an essential process for the maturation nearly all mammalian mRNAs. Recent studies show that AS contributes to expanding cancer-specific modulating immunogenicity, making it promising solution above challenges. The organoid technology preserves individual immune microenvironment reduces time/economic costs experiment model, facilitating development splicing-based immunotherapy. Here, we summarize three critical roles immunotherapy: resources generating neoantigens, targets immune-therapeutic modulation, biomarkers guide options. Subsequently, highlight benefits adopting organoids develop AS-based immunotherapies. Finally, discuss current challenges studying terms existing bioinformatics algorithms biological technologies.
Язык: Английский
Процитировано
11
Computers in Biology and Medicine, Год журнала: 2024, Номер 180, С. 108866 - 108866
Опубликована: Июль 31, 2024
Drug resistance is one of the biggest challenges in fight against cancer. In particular, case glioblastoma, most lethal brain tumour, to temozolomide (the standard care drug for chemotherapy this tumour) main reasons behind treatment failure and hence responsible poor prognosis patients diagnosed with disease. work, we combine power three-dimensional vitro experiments treated glioblastoma spheroids mathematical models tumour evolution adaptation. We use a novel approach based on internal variables modelling acquisition that was observed group spheroids. These describe cell's phenotypic state, which depends history exposure affects cell behaviour. model selection determine parsimonious calibrate it reproduce experimental data, obtaining high level agreement between silico outcomes. A sensitivity analysis carried out investigate impact each parameter predictions. More importantly, show how useful answering biological questions, such as what intrinsic adaptation mechanism, or separating sensitive resistant populations. conclude proposed framework, combination experiments, can be improve our understanding mechanisms eventually set some guidelines design new schemes.
Язык: Английский
Процитировано
4
Frontiers in Oncology, Год журнала: 2025, Номер 15
Опубликована: Фев. 7, 2025
This review summarizes the applications and research progress of organoid models in colorectal cancer research. First, high incidence mortality rates are introduced, emphasizing importance organoids as a model. Second, this provides detailed introduction to concept, biological properties, organoids, including their strengths mimicking structural functional aspects organs. article further analyzes adult stem cell-derived pluripotent discusses advancements for basic research, drug development, personalized treatment evaluation prediction, regenerative medicine. Finally, prospects applying technology its significant value improving patient survival rates. In conclusion, systematically explains highlighting tremendous potential promising
Язык: Английский
Процитировано
0
Current Oncology Reports, Год журнала: 2025, Номер unknown
Опубликована: Апрель 4, 2025
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(41), С. 9840 - 9866
Опубликована: Янв. 1, 2023
This review categorizes and describes the applications of SAzymes, explores methods for regulating their activity, provides a comprehensive overview biosafety challenges associated with these enzymes.
Язык: Английский
Процитировано
8