Inorganic and Nano-Metal Chemistry,
Год журнала:
2022,
Номер
53(4), С. 366 - 387
Опубликована: Апрель 27, 2022
STitanium
nitride,
a
substitute
plasmonic
material
to
gold
with
exceptional
features
is
favorable
photo-absorbing
agent
for
photothermal
therapy
(PTT)
based
on
the
spectral
match
of
their
plasmon
resonance
band
and
biological
transparency
window
as
well
good
biocompatibility.
Nevertheless,
review
its
synthesis
possible
utilization
in
cancer
has
never
been
explored.
This
presents
synthetic
routes
titanium
nitrides
(TiN)
nanoparticles
(NPs)
performance
therapy.
The
techniques
that
were
looked
into
are
solvothermal,
hydrothermal,
sol-gel,
laser
ablation,
chemical
vapor
deposition
non-thermal
plasma
techniques.
study
established
extraordinary
prospect
TiN
NPs
treatment
via
Chemical Reviews,
Год журнала:
2024,
Номер
124(13), С. 8307 - 8472
Опубликована: Июнь 26, 2024
Due
to
the
intrinsic
non-invasive
nature,
cost-effectiveness,
high
safety,
and
real-time
capabilities,
besides
diagnostic
imaging,
ultrasound
as
a
typical
mechanical
wave
has
been
extensively
developed
physical
tool
for
versatile
biomedical
applications.
Especially,
prosperity
of
nanotechnology
nanomedicine
invigorates
landscape
ultrasound-based
medicine.
The
unprecedented
surge
in
research
enthusiasm
dedicated
efforts
have
led
mass
multifunctional
micro-/nanosystems
being
applied
biomedicine,
facilitating
precise
diagnosis,
effective
treatment,
personalized
theranostics.
deployment
applications
is
rooted
profound
understanding
relationship
among
composition,
structure,
property,
bioactivity,
application,
performance.
In
this
comprehensive
review,
we
elaborate
on
general
principles
regarding
design,
synthesis,
functionalization,
optimization
abundant
particular,
recent
advancements
imaging
are
meticulously
summarized.
Furthermore,
systematically
elucidate
state-of-the-art
studies
concerning
progress
therapeutic
targeting
various
pathological
abnormalities
including
cancer,
bacterial
infection,
brain
diseases,
cardiovascular
metabolic
diseases.
Finally,
conclude
provide
an
outlook
field
with
in-depth
discussion
challenges
faced
future
developments
further
extensive
clinical
translation
application.
Sonodynamic
therapy
(SDT)
has
considerably
revolutionized
the
healthcare
sector
as
a
viable
noninvasive
therapeutic
procedure.
It
employs
combination
of
low-intensity
ultrasound
and
chemical
entities,
known
sonosensitizer,
to
produce
cytotoxic
reactive
oxygen
species
(ROS)
for
cancer
antimicrobial
therapies.
With
nanotechnology,
several
unique
nanoplatforms
are
introduced
sonosensitizers,
including,
titanium-based
nanomaterials,
thanks
their
high
biocompatibility,
catalytic
efficiency,
customizable
physicochemical
features.
Additionally,
developing
sonosensitizers
facilitates
integration
SDT
with
other
treatment
modalities
(for
example,
chemotherapy,
chemodynamic
therapy,
photodynamic
photothermal
immunotherapy),
hence
increasing
overall
results.
This
review
summarizes
most
recent
developments
in
tissue
engineering
using
titanium
mediated
SDT.
The
synthesis
strategies
biosafety
aspects
Titanium-based
also
discussed.
Finally,
various
challenges
prospects
its
further
development
potential
clinical
translation
highlighted.
Abstract
Sonodynamic
therapy
(SDT)
as
a
promising
non‐invasive
anti‐tumor
means
features
the
preferable
penetration
depth,
which
nevertheless,
usually
can't
work
without
sonosensitizers.
Sonosensitizers
produce
reactive
oxygen
species
(ROS)
in
presence
of
ultrasound
to
directly
kill
tumor
cells,
and
concurrently
activate
immunity
especially
after
integration
with
microenvironment
(TME)‐engineered
nanobiotechnologies
combined
therapy.
Current
sonosensitizers
are
classified
into
organic
inorganic
ones,
current
most
reviews
only
cover
highlighted
their
applications.
However,
there
have
few
specific
that
focus
on
including
design
principles,
regulation,
etc.
In
this
review,
first
according
rationales
rather
than
composition,
action
underlying
chemistry
highlighted.
Afterward,
what
how
TME
is
regulated
based
sonosensitizers‐based
SDT
nanoplatform
an
emphasis
targets‐engineered
elucidated.
Additionally,
applications
non‐cancer
diseases
also
outlined.
Finally,
setbacks
challenges,
proposed
potential
solutions
future
directions
pointed
out.
This
review
provides
comprehensive
detailed
horizon
sonosensitizers,
will
arouse
more
attentions
SDT.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2021,
Номер
16(6), С. 738 - 761
Опубликована: Окт. 16, 2021
The
booming
photothermal
therapy
(PTT)
has
achieved
great
progress
in
non-invasive
oncotherapy,
and
paves
a
novel
way
for
clinical
oncotherapy.
Of
note,
mild
temperature
PTT
(mPTT)
of
42-45
°C
could
avoid
treatment
bottleneck
the
traditional
PTT,
including
nonspecific
injury
to
normal
tissues,
vasculature
host
antitumor
immunity.
However,
cancer
cells
can
resist
mPTT
via
heat
shock
response
autophagy,
thus
leading
insufficient
monotherapy
ablate
tumor.
To
overcome
deficient
efficacy
caused
by
thermo-resistance
mono
mPTT,
synergistic
therapies
towards
have
been
conducted
with
mPTT.
This
review
summarizes
recent
advances
nanomedicine-potentiated
treatment,
strategies
enhanced
single-mode
plus
therapies.
Moreover,
challenges
prospects
translation
are
discussed.
Nanoscale,
Год журнала:
2021,
Номер
13(39), С. 16571 - 16588
Опубликована: Янв. 1, 2021
Weak
acidity
(6.5-6.9)
and
limited
H2O2
level
in
the
tumor
microenvironment
(TME)
usually
impact
therapeutic
effect
of
chemodynamic
therapy
(CDT)
for
cancer.
A
Specific
TME
promotes
formation
an
immunosuppressive
results
high
rate
recurrence
metastasis
Fe3O4@ZIF-8/GOx@MnO2
multi-layer
core
shell
nanostructure
was
constructed
as
a
hybrid
nanozyme.
After
magnetic
targeting
site,
outermost
MnO2
catalyzed
to
produce
O2
broken
due
reaction
with
glutathione.
Due
acid
response,
ZIF-8
layer
would
crack
release
glucose
oxidase
(GOx)
Fe3O4.
The
generated
utilized
by
GOx
starvation
consume
gluconic
acid.
Fenton
efficiency
Fe(II)
improved
increased
concentration
enhanced
TME.
At
same
time,
intrinsic
photothermal
Fe3O4
upon
808
nm
laser
irradiation
promoted
activity
oxidase,
catalase-like,
ablated
primary
tumor.
Moreover,
nanozyme
can
facilitate
transformation
M2-type
macrophages
M1-type,
strong
systemic
antitumor
immune
induced.
synergy
multiple
modes
including
therapy,
CDT,
(PTT),
immunotherapy
be
realized
therapy.
