Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: Aug. 12, 2022
Glioblastoma
multiforme
(GBM)
represents
the
most
common
and
fatal
form
of
primary
invasive
brain
tumors
as
it
affects
a
great
number
patients
each
year
has
median
overall
survival
approximately
14.6
months
after
diagnosis.
Despite
intensive
treatment,
almost
all
with
GBM
experience
recurrence,
their
5-year
rate
is
5%.
At
present,
main
clinical
treatment
strategy
includes
surgical
resection,
radiotherapy,
chemotherapy.
However,
tumor
heterogeneity,
blood-brain
barrier,
glioma
stem
cells,
DNA
damage
repair
mechanisms
hinder
efficient
treatment.
The
emergence
nanometer-scale
diagnostic
therapeutic
approaches
in
cancer
medicine
due
to
establishment
nanotechnology
provides
novel
promising
tools
that
will
allow
us
overcome
these
difficulties.
This
review
summarizes
application
recent
progress
nanotechnology-based
monotherapies
(e.g.,
chemotherapy)
combination
strategies
(chemotherapy-based
combined
therapy)
for
describes
synergistic
enhancement
between
therapies
well
current
standard
therapy
its
deficiencies.
These
can
reduce
individual
drug-related
toxicities
significantly
enhance
efficiency
have
recently
undergone
rapid
development.
underlying
different
photodynamic
chemodynamic
been
systematically
summarized
here
an
attempt
developments
identify
directions
future
research.
clinically
significant
insights
GBM,
which
importance.
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Nanomedicine
Oncologic
Disease
Diagnostic
Tools
In
Vivo
Nanodiagnostics
Imaging.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(13), P. 8307 - 8472
Published: June 26, 2024
Due
to
the
intrinsic
non-invasive
nature,
cost-effectiveness,
high
safety,
and
real-time
capabilities,
besides
diagnostic
imaging,
ultrasound
as
a
typical
mechanical
wave
has
been
extensively
developed
physical
tool
for
versatile
biomedical
applications.
Especially,
prosperity
of
nanotechnology
nanomedicine
invigorates
landscape
ultrasound-based
medicine.
The
unprecedented
surge
in
research
enthusiasm
dedicated
efforts
have
led
mass
multifunctional
micro-/nanosystems
being
applied
biomedicine,
facilitating
precise
diagnosis,
effective
treatment,
personalized
theranostics.
deployment
applications
is
rooted
profound
understanding
relationship
among
composition,
structure,
property,
bioactivity,
application,
performance.
In
this
comprehensive
review,
we
elaborate
on
general
principles
regarding
design,
synthesis,
functionalization,
optimization
abundant
particular,
recent
advancements
imaging
are
meticulously
summarized.
Furthermore,
systematically
elucidate
state-of-the-art
studies
concerning
progress
therapeutic
targeting
various
pathological
abnormalities
including
cancer,
bacterial
infection,
brain
diseases,
cardiovascular
metabolic
diseases.
Finally,
conclude
provide
an
outlook
field
with
in-depth
discussion
challenges
faced
future
developments
further
extensive
clinical
translation
application.
Small,
Journal Year:
2024,
Volume and Issue:
20(25)
Published: Jan. 15, 2024
Abstract
Sonodynamic
therapy
(SDT)
as
a
promising
non‐invasive
anti‐tumor
means
features
the
preferable
penetration
depth,
which
nevertheless,
usually
can't
work
without
sonosensitizers.
Sonosensitizers
produce
reactive
oxygen
species
(ROS)
in
presence
of
ultrasound
to
directly
kill
tumor
cells,
and
concurrently
activate
immunity
especially
after
integration
with
microenvironment
(TME)‐engineered
nanobiotechnologies
combined
therapy.
Current
sonosensitizers
are
classified
into
organic
inorganic
ones,
current
most
reviews
only
cover
highlighted
their
applications.
However,
there
have
few
specific
that
focus
on
including
design
principles,
regulation,
etc.
In
this
review,
first
according
rationales
rather
than
composition,
action
underlying
chemistry
highlighted.
Afterward,
what
how
TME
is
regulated
based
sonosensitizers‐based
SDT
nanoplatform
an
emphasis
targets‐engineered
elucidated.
Additionally,
applications
non‐cancer
diseases
also
outlined.
Finally,
setbacks
challenges,
proposed
potential
solutions
future
directions
pointed
out.
This
review
provides
comprehensive
detailed
horizon
sonosensitizers,
will
arouse
more
attentions
SDT.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(21)
Published: Jan. 6, 2024
Abstract
Cancer
is
a
serious
health
problem
to
be
solved.
With
the
development
of
biomaterials,
enhanced
diagnostic
and
controllable
therapeutic
strategies
for
cancer
have
emerged,
revealing
encouraging
results
with
promising
future.
Due
its
outstanding
tissue
penetration
controllability,
along
series
bioeffects
on
tissues,
ultrasound
(US),
as
common
medical
technology,
has
been
regarded
an
effective
tool
against
cancer,
use
promoted
exploration
US‐sensitive
biomaterials.
In
this
review,
US
are
first
introduced
then
main
biomaterials
(containing
cavitation
nuclei,
sonosensitizers,
US‐responsive
macromolecular
systems)
used
treat
followed
by
summary
several
applications
based
from
diagnosis
therapy.
Finally,
emerging
challenges
in
field
that
need
overcome
highlighted.
This
review
reports
progress
providing
new
possibilities
theranostics
thus
benefiting
patients.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2021,
Volume and Issue:
16(6), P. 738 - 761
Published: Oct. 16, 2021
The
booming
photothermal
therapy
(PTT)
has
achieved
great
progress
in
non-invasive
oncotherapy,
and
paves
a
novel
way
for
clinical
oncotherapy.
Of
note,
mild
temperature
PTT
(mPTT)
of
42-45
°C
could
avoid
treatment
bottleneck
the
traditional
PTT,
including
nonspecific
injury
to
normal
tissues,
vasculature
host
antitumor
immunity.
However,
cancer
cells
can
resist
mPTT
via
heat
shock
response
autophagy,
thus
leading
insufficient
monotherapy
ablate
tumor.
To
overcome
deficient
efficacy
caused
by
thermo-resistance
mono
mPTT,
synergistic
therapies
towards
have
been
conducted
with
mPTT.
This
review
summarizes
recent
advances
nanomedicine-potentiated
treatment,
strategies
enhanced
single-mode
plus
therapies.
Moreover,
challenges
prospects
translation
are
discussed.
Nanoscale,
Journal Year:
2021,
Volume and Issue:
13(39), P. 16571 - 16588
Published: Jan. 1, 2021
Weak
acidity
(6.5-6.9)
and
limited
H2O2
level
in
the
tumor
microenvironment
(TME)
usually
impact
therapeutic
effect
of
chemodynamic
therapy
(CDT)
for
cancer.
A
Specific
TME
promotes
formation
an
immunosuppressive
results
high
rate
recurrence
metastasis
Fe3O4@ZIF-8/GOx@MnO2
multi-layer
core
shell
nanostructure
was
constructed
as
a
hybrid
nanozyme.
After
magnetic
targeting
site,
outermost
MnO2
catalyzed
to
produce
O2
broken
due
reaction
with
glutathione.
Due
acid
response,
ZIF-8
layer
would
crack
release
glucose
oxidase
(GOx)
Fe3O4.
The
generated
utilized
by
GOx
starvation
consume
gluconic
acid.
Fenton
efficiency
Fe(II)
improved
increased
concentration
enhanced
TME.
At
same
time,
intrinsic
photothermal
Fe3O4
upon
808
nm
laser
irradiation
promoted
activity
oxidase,
catalase-like,
ablated
primary
tumor.
Moreover,
nanozyme
can
facilitate
transformation
M2-type
macrophages
M1-type,
strong
systemic
antitumor
immune
induced.
synergy
multiple
modes
including
therapy,
CDT,
(PTT),
immunotherapy
be
realized
therapy.
