Neurochemistry International, Journal Year: 2025, Volume and Issue: 185, P. 105961 - 105961
Published: March 5, 2025
Language: Английский
Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(9), P. 3625 - 3637
Published: Sept. 1, 2023
Abstract The human body harbors a diverse ecosystem of microorganisms, including bacteria, viruses, and fungi, collectively known as the microbiota. Current research is increasingly focusing on potential association between microbiota various neuropsychiatric disorders. resides in parts body, such oral cavity, nasal passages, lungs, gut, skin, bladder, vagina. gut gastrointestinal tract has received particular attention due to its high abundance role psychiatric neurodegenerative However, presents other tissues, though less abundant, also plays crucial immune system homeostasis, thus influencing development progression For example, imbalance associated periodontitis might increase risk for Additionally, studies using postmortem brain samples have detected widespread presence bacteria brains patients with Alzheimer’s disease. This article provides an overview emerging host disorders discusses future directions, underlying biological mechanisms, reliable biomarkers microbiota, microbiota-targeted interventions, this field.
Language: Английский
Citations
50
Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13
Published: Feb. 24, 2023
Polycystic ovary syndrome (PCOS) is the most common endocrine diseases in women of childbearing age that leads to menstrual disorders and infertility. The pathogenesis PCOS complex has not yet been fully clarified. Gut microbiota associated with lipid, glucose, steroid hormone metabolish. A large body studies demonstrated gut could regulate synthesis secretion insulin, affect androgen metabolism follicle development, providing us a novel idea for unravelling PCOS. relationship between particularly important. This study reviewed recent research advances roles occurrence development It expected provide new direction treatment based on microbiota.
Language: Английский
Citations
42
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217539 - 217539
Published: Feb. 1, 2025
Language: Английский
Citations
2
Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(12), P. 4968 - 4976
Published: July 4, 2023
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection has resulted in a serious public health burden worldwide. In addition to respiratory, heart, and gastrointestinal symptoms, patients infected with SARS-CoV-2 experience number of persistent neurological psychiatric known as long COVID or "brain fog". Studies autopsy samples from who died COVID-19 detected the brain. Furthermore, increasing evidence shows that Epstein-Barr virus (EBV) reactivation after might play role symptoms. Moreover, alterations microbiome contribute this article, author reviews detrimental effects on brain, biological mechanisms (e.g., EBV reactivation, changes gut, nasal, oral, lung microbiomes) underlying COVID. addition, discusses potential therapeutic approaches based gut-brain axis, including plant-based diet, probiotics prebiotics, fecal microbiota transplantation, vagus nerve stimulation, sigma-1 receptor agonist fluvoxamine.
Language: Английский
Citations
35
Progress in brain research, Journal Year: 2023, Volume and Issue: unknown, P. 61 - 77
Published: Jan. 1, 2023
Language: Английский
Citations
31
Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 191, P. 106396 - 106396
Published: Jan. 2, 2024
Studies from rodents to primates and humans indicate that individuals vary in how resilient they are stress, understanding the basis of these variations may help improve treatments for depression. Here we explored potential contribution gut microbiome such variation. Mice were exposed chronic unpredictable mild stress (CUMS) 4 weeks then allowed recover 3 weeks, after which subjected behavioral tests categorized as showing low or high resilience. The two types mouse compared terms hippocampal gene expression using RNA sequencing, fecal microbiomes 16S extent neurogenesis hippocampus immunostaining brain sections. Fecal microbiota transplanted either type into previously stress-exposed stress-naïve animals, effects transplantation on stress-induced behaviors examined. Finally, blocked temozolomide explore role promoted by enhancing resilience stress. Results showed highly stress-resilient mice, but not those with resilience, improved significantly measures anhedonia, despair, anxiety 3-week recovery CUMS. Their feces greater abundance Lactobacillus, Bifidobacterium Romboutsia than mice well lower Staphylococcus, Psychrobacter Corynebacterium. Similarly, animals Transplanting CUMS-exposed recipients rescued hippocampus, facilitating depression cognitive decline. Blockade abolished CUMS-induced decline In conclusion, our results suggested remodeling reverse impairment thereby promote
Language: Английский
Citations
12
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: Feb. 27, 2024
Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the distributed over body surface. Studies suggest a correlation between brain-gut-microbiota (BGM) axis and pathogenesis Alzheimer’s disease (AD). The BGM represents complex bidirectional communication system, with being crucial component. Therefore, electrical might have potential modify—most time probably in non-physiological way—the signal transmission within axis, potentially influencing progression or symptoms AD. This review explores interaction percutaneous emphasizing its effects on It examines various aspects, such as specific brain regions, gut microbiota composition, maintenance intestinal environmental homeostasis, inflammatory responses, plasticity, hypothalamic–pituitary–adrenal (HPA) regulation. suggests that tVNS could serve effective strategy modulate intervene treatment future.
Language: Английский
Citations
12
Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 36, P. 100729 - 100729
Published: Jan. 23, 2024
Communication among the brain, gut and microbiota in is known to affect susceptibility stress, but mechanisms involved are unclear. Here we demonstrated that stress resistance mice was associated with more abundant
Language: Английский
Citations
11
Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 192, P. 106433 - 106433
Published: Feb. 7, 2024
Depression frequently occurs in patients with liver cirrhosis, yet the reasons for this correlation are not fully understood. Dysbiosis of gut microbiota has been implicated depression through gut–brain axis via vagus nerve. This study explored potential role gut–liver–brain nerve depression-like phenotypes mice cirrhosis. These underwent common bile duct ligation (CBDL), a method used to stimulate To assess behaviors, behavioral tests were conducted 10 days following either sham or CBDL surgeries. The displayed symptoms such as splenomegaly, elevated plasma levels interleukin-6 and tumor necrosis factor-α, decreased synaptic proteins prefrontal cortex (PFC), disrupted balance, changes blood metabolites (or lipids). Additionally, there positive negative correlations between relative abundance microbiome data Significantly, these reversed by performing subdiaphragmatic vagotomy. Intriguingly, improved after single injection arketamine, new antidepressant. results suggest that CBDL-induced mediated nerve, arketamine might offer treatment approach cirrhosis patients.
Language: Английский
Citations
11
Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
9