Abstract
Flavonoids
are
a
major
class
of
polyphenolic
compounds
that
occur
naturally
in
plants
and
widely
distributed
various
dietary
products.
exhibit
prominent
physicochemical
properties
biological
activities,
thereby
garnering
considerable
attention.
Notably,
the
functionalities
flavonoids
structurally
dependent.
Variations
chemical
structure
lead
to
differences
characteristics
among
different
flavonoid
types.
Structural
alterations
can
modify
these
characteristics,
influencing
activities
mechanisms
action.
However,
structural
variations
their
implication
have
not
been
comprehensively
elucidated.
In
this
review,
we
outline
flavonoids,
discuss
biosynthesis,
vivo
digestion,
absorption,
particularly
emphasize
diverse
action
associated
with
structures.
By
summarizing
current
scientific
findings,
aim
elucidate
structure–activity
relationships
provide
theoretical
basis
for
development
new
applications,
which
will
help
target
design
functional
molecules
moieties
food
pharmaceutical
industries
use
drug
development.
Practical
Application
:
Understanding
guide
products
supplements
targeted
health
benefits.
leveraging
knowledge
relationships,
food,
innovate
formulations
enhance
bioavailability
efficacy,
potentially
leading
creation
tailored
specific
conditions
or
needs.
This
research
lays
groundwork
novel
flavonoid‐based
interventions
aimed
at
promoting
human
well‐being.
Phytotherapy Research,
Год журнала:
2024,
Номер
38(6), С. 3060 - 3079
Опубликована: Апрель 11, 2024
Abstract
Phytoestrogens,
also
known
as
xenoestrogens,
are
secondary
metabolites
derived
from
plants
that
have
similar
structures
and
biological
effects
human
estrogens.
These
compounds
do
not
directly
affect
functions
but
can
act
agonists
or
antagonists
depending
on
the
level
of
endogenous
estrogen
in
body.
Phytoestrogens
may
an
epigenetic
mechanism
action
independent
receptors.
found
more
than
300
plant
species
synthesized
through
phenylpropanoid
pathway,
with
specific
enzymes
leading
to
various
chemical
structures.
primarily
phenolic
compounds,
include
isoflavonoids,
flavonoids,
stilbenes,
lignans.
Extensive
research
animals
humans
has
demonstrated
protective
phytoestrogens
estrogen‐dependent
diseases.
Clinical
trials
shown
their
potential
benefits
conditions
such
osteoporosis,
Parkinson's
disease,
certain
types
cancer.
This
review
provides
a
concise
overview
phytoestrogen
classification,
diversity,
biosynthesis
discusses
therapeutic
phytoestrogens,
well
preclinical
clinical
development.
Pharmacological Research,
Год журнала:
2024,
Номер
204, С. 107201 - 107201
Опубликована: Май 3, 2024
Neuropsychiatric
disorders
shorten
human
life
spans
through
multiple
ways
and
become
major
threats
to
health.
Exercise
can
regulate
the
estrogen
signaling,
which
may
be
involved
in
depression,
Alzheimer's
disease
(AD)
Parkinson's
(PD),
other
neuropsychiatric
as
well
their
sex
differences.
In
nervous
system,
is
an
important
regulator
of
cell
development,
synaptic
brain
connectivity.
Therefore,
this
review
aimed
investigate
potential
system
exercise
intervention
better
understand
its
specific.
exert
a
protective
effect
regulating
expression
receptors,
are
neuroprotection,
neurodevelopment,
neuronal
glucose
homeostasis.
These
processes
mediated
by
downstream
factors
including
N-myc
regulatory
gene
2
(Ndrg2),
serotonin
(5-HT),
delta
like
canonical
Notch
ligand
1
(DLL1),
NOD-like
receptor
thermal
protein
domain
associated
3
(NLRP3),
etc.
addition,
act
on
response
element
(ERE)
fragment
genes
estrogenic
β-amyloid
precursor
cleavase
(BACE1).
However,
there
few
studies
relationship
between
exercise,
signaling
pathway,
disorders.
Hence,
we
how
mediates
mechanism
We
aim
provide
theoretical
perspective
for
affecting
female
health
support
design
prescriptions.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(2), С. 1311 - 1311
Опубликована: Янв. 9, 2023
Potassium
channels
are
widely
distributed
integral
proteins
responsible
for
the
effective
and
selective
transport
of
K+
ions
through
biological
membranes.
According
to
existing
structural
mechanistic
differences,
they
divided
into
several
groups.
All
them
considered
important
molecular
drug
targets
due
their
physiological
roles,
including
regulation
membrane
potential
or
cell
signaling.
One
recent
trends
in
pharmacology
is
evaluation
therapeutic
natural
compounds
derivatives,
which
can
exhibit
high
specificity
effectiveness.
Among
pharmaceuticals
plant
origin,
potassium
channel
modulators,
flavonoids
appear
as
a
powerful
group
biologically
active
substances.
It
caused
by
well-documented
anti-oxidative,
anti-inflammatory,
anti-mutagenic,
anti-carcinogenic,
antidiabetic
effects
on
human
health.
Here,
we
focus
presenting
current
state
knowledge
about
possibilities
modulation
particular
types
different
flavonoids.
Additionally,
meaning
flavonoid-mediated
changes
activity
will
be
outlined.
Finally,
novel
promising
directions
further
research
this
area
proposed.
Dermatology and Therapy,
Год журнала:
2022,
Номер
12(7), С. 1535 - 1550
Опубликована: Июнь 25, 2022
Emerging
scientific
advances
in
microbial
research
linking
estrogens
and
the
gut-skin
microbiome
reference
to
dermal
health
are
featured
this
narrative
review
of
journal
reports
reviews
from
January
2018
through
February
2022.
Background
information
on
along
with
defining
microbiota
is
presented
brief.
The
development
factors
that
influence
gut
disease
as
well
intrinsic
extrinsic
influencing
skin
aging
summarized.
New
changes
organ
microbiomes
have
exposed
similarities
between
structure/function,
components/diversity/taxonomy
how
they
impact
immune
response
for
combating
enhancing
wellness.
Estrogens
promote
support
homeostasis
general
directly
health.
Moreover,
gut,
based
upon
level
enzyme
β-glucuronidase,
which
regulates
estrogen's
enterohepatic
recirculation,
constitutes
a
axis.
This
axis
revolves
around
systemically
available
estrogen
function,
counteract
inflammation
oxidative
stress,
decrease
risk
hormone-dependent
cancers.
These
data
direct
effect
interaction
diet
via
effects
microflora.
Finally,
potential
bioactive
botanicals
containing
phytoestrogens
or
selective
receptor
modulators
(SERMs)
evade
β-glucuronidase
expressing
flora
proposed
may
positive
skin.
World Journal of Clinical Cases,
Год журнала:
2023,
Номер
11(6), С. 1236 - 1244
Опубликована: Фев. 21, 2023
Metabolic-associated
fatty
liver
disease
(MAFLD)
refers
to
the
build-up
of
fat
in
associated
with
metabolic
dysfunction
and
has
been
estimated
affect
a
quarter
population
worldwide.
Although
metabolism
is
highly
influenced
by
effects
sex
hormones,
studies
differences
incidence
progression
MAFLD
are
scarce.
Metabolomics
represents
powerful
approach
studying
these
identifying
potential
biomarkers
putative
mechanisms.
First,
metabolomics
makes
it
possible
obtain
molecular
phenotype
individual
at
given
time.
Second,
may
be
helpful
tool
for
classifying
patients
according
severity
obtaining
diagnostic
biomarkers.
Some
demonstrate
associations
between
circulating
metabolites
early
established
MAFLD,
but
little
known
about
how
relate
encompass
risk
management.
In
this
review,
we
will
discuss
epidemiological
metabolomic
development
role
profiles
understanding
mechanisms
sex-dependent
biomarkers,
evidence
help
future
management
disease.
Cosmetics,
Год журнала:
2023,
Номер
10(5), С. 142 - 142
Опубликована: Окт. 12, 2023
Lifestyle
health
has
been
recognized
as
an
evidence-based
innovation
that
defines
how
everyday
behaviors
and
routines
influence
the
avoidance
therapy
of
illness
provides
important
adjunctive
component
to
overall
health.
Specifically,
approach
with
small
changes
over
time
can
have
a
dramatic
impact
on
well-being
individuals
not
only,
in
general,
but
also
be
applied
skin
However,
lifestyle
factors
improve
discussed
extensively
and/or
well
promulgated.
The
narrative
for
this
overview
focuses
providing
summary
topic
background
information,
more
importantly,
presents
four
dermal
[i.e.,
factor
1:
nutrition—diet;
2:
rest
(sleep);
3:
movement/physical
exercise,
4:
social
community
associations].
This
was
accomplished
by
identifying
preceding
journal
reports/reviews
covering
especially
last
five
years
(January
2018
July
2023;
164
out
205
references
cited
or
80%)
using
scientific
search
databases.
main
conclusions
encourage
concept
such
nutrition/diet,
rest/sleep,
community/social
interactions
support
enhanced
aging.
Plus,
media
interventions
aim
promote
dietary,
sleep
physical
activity
might
application
future.
