Structural insights and biological activities of flavonoids: Implications for novel applications DOI Creative Commons
Sheng Tang, Botao Wang, Xin Liu

et al.

Food Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Flavonoids are a major class of polyphenolic compounds that occur naturally in plants and widely distributed various dietary products. exhibit prominent physicochemical properties biological activities, thereby garnering considerable attention. Notably, the functionalities flavonoids structurally dependent. Variations chemical structure lead to differences characteristics among different flavonoid types. Structural alterations can modify these characteristics, influencing activities mechanisms action. However, structural variations their implication have not been comprehensively elucidated. In this review, we outline flavonoids, discuss biosynthesis, vivo digestion, absorption, particularly emphasize diverse action associated with structures. By summarizing current scientific findings, aim elucidate structure–activity relationships provide theoretical basis for development new applications, which will help target design functional molecules moieties food pharmaceutical industries use drug development. Practical Application : Understanding guide products supplements targeted health benefits. leveraging knowledge relationships, food, innovate formulations enhance bioavailability efficacy, potentially leading creation tailored specific conditions or needs. This research lays groundwork novel flavonoid‐based interventions aimed at promoting human well‐being.

Language: Английский

Cyano-functionalized ionic porous polymer: A novel adsorbent for effectively enriching trace estrogens in water and milk DOI

Zixuan Cai,

Xin Zhou,

Yushi Yang

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 466, P. 143315 - 143315

Published: May 4, 2023

Language: Английский

Citations

46
Diet and skin health: The good and the bad DOI
Idris Adewale Ahmed, Maryam Abimbola Mikail

Nutrition, Journal Year: 2024, Volume and Issue: 119, P. 112350 - 112350

Published: Jan. 2, 2024

Language: Английский

Citations

18
Estrogen pollution of the European aquatic environment: A critical review DOI
Marianna Ciślak, Izabela Kruszelnicka, Joanna Zembrzuska

et al.

Water Research, Journal Year: 2022, Volume and Issue: 229, P. 119413 - 119413

Published: Nov. 25, 2022

Language: Английский

Citations

62
Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance DOI Creative Commons
Vivek P. Chavda, Amit Z. Chaudhari, Pankti C. Balar

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(6), P. 3060 - 3079

Published: April 11, 2024

Abstract Phytoestrogens, also known as xenoestrogens, are secondary metabolites derived from plants that have similar structures and biological effects human estrogens. These compounds do not directly affect functions but can act agonists or antagonists depending on the level of endogenous estrogen in body. Phytoestrogens may an epigenetic mechanism action independent receptors. found more than 300 plant species synthesized through phenylpropanoid pathway, with specific enzymes leading to various chemical structures. primarily phenolic compounds, include isoflavonoids, flavonoids, stilbenes, lignans. Extensive research animals humans has demonstrated protective phytoestrogens estrogen‐dependent diseases. Clinical trials shown their potential benefits conditions such osteoporosis, Parkinson's disease, certain types cancer. This review provides a concise overview phytoestrogen classification, diversity, biosynthesis discusses therapeutic phytoestrogens, well preclinical clinical development.

Language: Английский

Citations

8
Unveiling the potential of estrogen: Exploring its role in neuropsychiatric disorders and exercise intervention DOI Creative Commons

Wenke He,

Sen Zhang, Zhengtang Qi

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 204, P. 107201 - 107201

Published: May 3, 2024

Neuropsychiatric disorders shorten human life spans through multiple ways and become major threats to health. Exercise can regulate the estrogen signaling, which may be involved in depression, Alzheimer's disease (AD) Parkinson's (PD), other neuropsychiatric as well their sex differences. In nervous system, is an important regulator of cell development, synaptic brain connectivity. Therefore, this review aimed investigate potential system exercise intervention better understand its specific. exert a protective effect regulating expression receptors, are neuroprotection, neurodevelopment, neuronal glucose homeostasis. These processes mediated by downstream factors including N-myc regulatory gene 2 (Ndrg2), serotonin (5-HT), delta like canonical Notch ligand 1 (DLL1), NOD-like receptor thermal protein domain associated 3 (NLRP3), etc. addition, act on response element (ERE) fragment genes estrogenic β-amyloid precursor cleavase (BACE1). However, there few studies relationship between exercise, signaling pathway, disorders. Hence, we how mediates mechanism We aim provide theoretical perspective for affecting female health support design prescriptions.

Language: Английский

Citations

6
Biochanin A as a modulator of the inflammatory response: An updated overview and therapeutic potential DOI Creative Commons
Franciel Batista Félix, Juliana P. Vago,

Vinícius Amorim Beltrami

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 180, P. 106246 - 106246

Published: May 10, 2022

Language: Английский

Citations

26
Flavonoids as Modulators of Potassium Channels DOI Open Access
M. Richter, Paulina Trybek, Domenico Vittorio Delfino

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1311 - 1311

Published: Jan. 9, 2023

Potassium channels are widely distributed integral proteins responsible for the effective and selective transport of K+ ions through biological membranes. According to existing structural mechanistic differences, they divided into several groups. All them considered important molecular drug targets due their physiological roles, including regulation membrane potential or cell signaling. One recent trends in pharmacology is evaluation therapeutic natural compounds derivatives, which can exhibit high specificity effectiveness. Among pharmaceuticals plant origin, potassium channel modulators, flavonoids appear as a powerful group biologically active substances. It caused by well-documented anti-oxidative, anti-inflammatory, anti-mutagenic, anti-carcinogenic, antidiabetic effects on human health. Here, we focus presenting current state knowledge about possibilities modulation particular types different flavonoids. Additionally, meaning flavonoid-mediated changes activity will be outlined. Finally, novel promising directions further research this area proposed.

Language: Английский

Citations

15
Estrogen Action and Gut Microbiome Metabolism in Dermal Health DOI Creative Commons
Edwin D. Lephart, Frederick Naftolin

Dermatology and Therapy, Journal Year: 2022, Volume and Issue: 12(7), P. 1535 - 1550

Published: June 25, 2022

Emerging scientific advances in microbial research linking estrogens and the gut-skin microbiome reference to dermal health are featured this narrative review of journal reports reviews from January 2018 through February 2022. Background information on along with defining microbiota is presented brief. The development factors that influence gut disease as well intrinsic extrinsic influencing skin aging summarized. New changes organ microbiomes have exposed similarities between structure/function, components/diversity/taxonomy how they impact immune response for combating enhancing wellness. Estrogens promote support homeostasis general directly health. Moreover, gut, based upon level enzyme β-glucuronidase, which regulates estrogen's enterohepatic recirculation, constitutes a axis. This axis revolves around systemically available estrogen function, counteract inflammation oxidative stress, decrease risk hormone-dependent cancers. These data direct effect interaction diet via effects microflora. Finally, potential bioactive botanicals containing phytoestrogens or selective receptor modulators (SERMs) evade β-glucuronidase expressing flora proposed may positive skin.

Language: Английский

Citations

19
Sex dimorphism and metabolic profiles in management of metabolic-associated fatty liver disease DOI Open Access
María Martín-Grau, Daniel Monleón

World Journal of Clinical Cases, Journal Year: 2023, Volume and Issue: 11(6), P. 1236 - 1244

Published: Feb. 21, 2023

Metabolic-associated fatty liver disease (MAFLD) refers to the build-up of fat in associated with metabolic dysfunction and has been estimated affect a quarter population worldwide. Although metabolism is highly influenced by effects sex hormones, studies differences incidence progression MAFLD are scarce. Metabolomics represents powerful approach studying these identifying potential biomarkers putative mechanisms. First, metabolomics makes it possible obtain molecular phenotype individual at given time. Second, may be helpful tool for classifying patients according severity obtaining diagnostic biomarkers. Some demonstrate associations between circulating metabolites early established MAFLD, but little known about how relate encompass risk management. In this review, we will discuss epidemiological metabolomic development role profiles understanding mechanisms sex-dependent biomarkers, evidence help future management disease.

Language: Английский

Citations

12
Enhancing Skin Anti-Aging through Healthy Lifestyle Factors DOI Creative Commons

Helen Knaggs,

Edwin D. Lephart

Cosmetics, Journal Year: 2023, Volume and Issue: 10(5), P. 142 - 142

Published: Oct. 12, 2023

Lifestyle health has been recognized as an evidence-based innovation that defines how everyday behaviors and routines influence the avoidance therapy of illness provides important adjunctive component to overall health. Specifically, approach with small changes over time can have a dramatic impact on well-being individuals not only, in general, but also be applied skin However, lifestyle factors improve discussed extensively and/or well promulgated. The narrative for this overview focuses providing summary topic background information, more importantly, presents four dermal [i.e., factor 1: nutrition—diet; 2: rest (sleep); 3: movement/physical exercise, 4: social community associations]. This was accomplished by identifying preceding journal reports/reviews covering especially last five years (January 2018 July 2023; 164 out 205 references cited or 80%) using scientific search databases. main conclusions encourage concept such nutrition/diet, rest/sleep, community/social interactions support enhanced aging. Plus, media interventions aim promote dietary, sleep physical activity might application future.

Language: Английский

Citations

12